| Full name: synuclein alpha | Alias Symbol: NACP|PD1 | ||
| Type: protein-coding gene | Cytoband: 4q22.1 | ||
| Entrez ID: 6622 | HGNC ID: HGNC:11138 | Ensembl Gene: ENSG00000145335 | OMIM ID: 163890 |
| Drug and gene relationship at DGIdb | |||
Expression of SNCA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SNCA | 6622 | 204466_s_at | -0.3088 | 0.8113 | |
| GSE20347 | SNCA | 6622 | 211546_x_at | -0.0606 | 0.4948 | |
| GSE23400 | SNCA | 6622 | 204466_s_at | 0.0736 | 0.5379 | |
| GSE26886 | SNCA | 6622 | 207827_x_at | 0.2434 | 0.1096 | |
| GSE29001 | SNCA | 6622 | 204467_s_at | -0.3376 | 0.2951 | |
| GSE38129 | SNCA | 6622 | 211546_x_at | -0.0930 | 0.2552 | |
| GSE45670 | SNCA | 6622 | 207827_x_at | -0.2734 | 0.0072 | |
| GSE63941 | SNCA | 6622 | 204466_s_at | -1.3283 | 0.4460 | |
| GSE77861 | SNCA | 6622 | 207827_x_at | -0.1444 | 0.2928 | |
| GSE97050 | SNCA | 6622 | A_23_P29939 | -0.3674 | 0.4273 | |
| SRP064894 | SNCA | 6622 | RNAseq | -0.3274 | 0.3909 | |
| SRP133303 | SNCA | 6622 | RNAseq | -0.6661 | 0.0631 | |
| SRP159526 | SNCA | 6622 | RNAseq | 0.0128 | 0.9777 | |
| SRP219564 | SNCA | 6622 | RNAseq | 0.6475 | 0.3505 | |
| TCGA | SNCA | 6622 | RNAseq | 0.2638 | 0.2787 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SNCA expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SNCA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SNCA | 6622 | 0 | 13 | 17 | |
| GSE20123 | SNCA | 6622 | 0 | 13 | 17 | |
| GSE43470 | SNCA | 6622 | 0 | 13 | 30 | |
| GSE46452 | SNCA | 6622 | 1 | 36 | 22 | |
| GSE47630 | SNCA | 6622 | 0 | 20 | 20 | |
| GSE54993 | SNCA | 6622 | 8 | 0 | 62 | |
| GSE54994 | SNCA | 6622 | 2 | 10 | 41 | |
| GSE60625 | SNCA | 6622 | 3 | 0 | 8 | |
| GSE74703 | SNCA | 6622 | 0 | 11 | 25 | |
| GSE74704 | SNCA | 6622 | 0 | 8 | 12 | |
| TCGA | SNCA | 6622 | 10 | 36 | 50 |
Total number of gains: 24; Total number of losses: 160; Total Number of normals: 304.
Somatic mutations of SNCA:
Generating mutation plots.
Highly correlated genes for SNCA:
Showing top 20/125 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SNCA | TRIM61 | 0.824986 | 3 | 0 | 3 |
| SNCA | NES | 0.801998 | 3 | 0 | 3 |
| SNCA | HEYL | 0.741949 | 3 | 0 | 3 |
| SNCA | MXI1 | 0.73833 | 3 | 0 | 3 |
| SNCA | MT1F | 0.73595 | 3 | 0 | 3 |
| SNCA | CLDND1 | 0.71994 | 3 | 0 | 3 |
| SNCA | TIRAP | 0.714494 | 3 | 0 | 3 |
| SNCA | RRAS | 0.711391 | 3 | 0 | 3 |
| SNCA | GALM | 0.709451 | 3 | 0 | 3 |
| SNCA | HADHB | 0.709409 | 4 | 0 | 4 |
| SNCA | HSPA12A | 0.708311 | 3 | 0 | 3 |
| SNCA | CHURC1 | 0.706887 | 3 | 0 | 3 |
| SNCA | ALDH6A1 | 0.694642 | 3 | 0 | 3 |
| SNCA | EVC2 | 0.688714 | 3 | 0 | 3 |
| SNCA | CRYZ | 0.687192 | 4 | 0 | 3 |
| SNCA | HOXA5 | 0.680847 | 3 | 0 | 3 |
| SNCA | TMEM92 | 0.677005 | 3 | 0 | 3 |
| SNCA | TNFRSF8 | 0.676086 | 3 | 0 | 3 |
| SNCA | CD36 | 0.674431 | 3 | 0 | 3 |
| SNCA | NLGN4X | 0.672761 | 3 | 0 | 3 |
For details and further investigation, click here
