| Full name: myosin heavy chain 4 | Alias Symbol: MYH2B|MyHC-2B|MyHC-IIb | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 4622 | HGNC ID: HGNC:7574 | Ensembl Gene: ENSG00000264424 | OMIM ID: 160742 |
| Drug and gene relationship at DGIdb | |||
MYH4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of MYH4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYH4 | 4622 | 208148_at | -0.1257 | 0.5483 | |
| GSE20347 | MYH4 | 4622 | 208148_at | -0.0920 | 0.1008 | |
| GSE23400 | MYH4 | 4622 | 208148_at | -0.1041 | 0.0000 | |
| GSE26886 | MYH4 | 4622 | 208148_at | 0.0068 | 0.9458 | |
| GSE29001 | MYH4 | 4622 | 208148_at | -0.0431 | 0.6767 | |
| GSE38129 | MYH4 | 4622 | 208148_at | -0.1323 | 0.0021 | |
| GSE45670 | MYH4 | 4622 | 208148_at | 0.0008 | 0.9938 | |
| GSE53622 | MYH4 | 4622 | 6710 | -0.2327 | 0.0045 | |
| GSE53624 | MYH4 | 4622 | 6710 | -0.0259 | 0.7030 | |
| GSE63941 | MYH4 | 4622 | 208148_at | 0.0789 | 0.5467 | |
| GSE77861 | MYH4 | 4622 | 208148_at | -0.2044 | 0.0556 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MYH4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYH4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYH4 | 4622 | 2 | 4 | 24 | |
| GSE20123 | MYH4 | 4622 | 2 | 5 | 23 | |
| GSE43470 | MYH4 | 4622 | 2 | 5 | 36 | |
| GSE46452 | MYH4 | 4622 | 34 | 1 | 24 | |
| GSE47630 | MYH4 | 4622 | 7 | 1 | 32 | |
| GSE54993 | MYH4 | 4622 | 4 | 3 | 63 | |
| GSE54994 | MYH4 | 4622 | 5 | 7 | 41 | |
| GSE60625 | MYH4 | 4622 | 4 | 0 | 7 | |
| GSE74703 | MYH4 | 4622 | 2 | 3 | 31 | |
| GSE74704 | MYH4 | 4622 | 1 | 2 | 17 | |
| TCGA | MYH4 | 4622 | 17 | 20 | 59 |
Total number of gains: 80; Total number of losses: 51; Total Number of normals: 357.
Somatic mutations of MYH4:
Generating mutation plots.
Highly correlated genes for MYH4:
Showing top 20/109 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYH4 | FAM209B | 0.647775 | 3 | 0 | 3 |
| MYH4 | LINC00354 | 0.628876 | 3 | 0 | 3 |
| MYH4 | DNAJC28 | 0.623582 | 6 | 0 | 5 |
| MYH4 | HOXB1 | 0.614383 | 5 | 0 | 4 |
| MYH4 | PLG | 0.606063 | 3 | 0 | 3 |
| MYH4 | KIAA0087 | 0.605611 | 5 | 0 | 4 |
| MYH4 | RNF31 | 0.599631 | 3 | 0 | 3 |
| MYH4 | CRX | 0.589367 | 3 | 0 | 3 |
| MYH4 | NPAP1 | 0.584336 | 4 | 0 | 3 |
| MYH4 | MTUS2-AS1 | 0.583361 | 4 | 0 | 3 |
| MYH4 | C10orf67 | 0.582378 | 4 | 0 | 3 |
| MYH4 | RAX | 0.58063 | 5 | 0 | 4 |
| MYH4 | CACNG5 | 0.575964 | 4 | 0 | 3 |
| MYH4 | SSTR4 | 0.572367 | 6 | 0 | 5 |
| MYH4 | ADAM18 | 0.568516 | 4 | 0 | 3 |
| MYH4 | TSSK2 | 0.568144 | 5 | 0 | 5 |
| MYH4 | GRID2 | 0.567585 | 4 | 0 | 3 |
| MYH4 | WNT16 | 0.566072 | 4 | 0 | 3 |
| MYH4 | FEZF2 | 0.565283 | 5 | 0 | 4 |
| MYH4 | SLC28A2 | 0.563578 | 5 | 0 | 4 |
For details and further investigation, click here
