| Full name: ADAM metallopeptidase domain 18 | Alias Symbol: tMDCIII|ADAM27 | ||
| Type: protein-coding gene | Cytoband: 8p11.22 | ||
| Entrez ID: 8749 | HGNC ID: HGNC:196 | Ensembl Gene: ENSG00000168619 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of ADAM18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAM18 | 8749 | 207597_at | -0.0183 | 0.9479 | |
| GSE20347 | ADAM18 | 8749 | 207597_at | -0.0290 | 0.6614 | |
| GSE23400 | ADAM18 | 8749 | 207597_at | -0.0812 | 0.0014 | |
| GSE26886 | ADAM18 | 8749 | 207597_at | 0.0618 | 0.4948 | |
| GSE29001 | ADAM18 | 8749 | 207597_at | -0.0563 | 0.6571 | |
| GSE38129 | ADAM18 | 8749 | 207597_at | -0.1100 | 0.0456 | |
| GSE45670 | ADAM18 | 8749 | 207597_at | -0.0921 | 0.2709 | |
| GSE53622 | ADAM18 | 8749 | 93914 | 0.0604 | 0.6055 | |
| GSE53624 | ADAM18 | 8749 | 93914 | 0.1589 | 0.2033 | |
| GSE63941 | ADAM18 | 8749 | 207597_at | 0.1031 | 0.4655 | |
| GSE77861 | ADAM18 | 8749 | 207597_at | -0.0523 | 0.6677 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ADAM18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAM18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAM18 | 8749 | 10 | 4 | 16 | |
| GSE20123 | ADAM18 | 8749 | 10 | 4 | 16 | |
| GSE43470 | ADAM18 | 8749 | 8 | 7 | 28 | |
| GSE46452 | ADAM18 | 8749 | 20 | 5 | 34 | |
| GSE47630 | ADAM18 | 8749 | 32 | 1 | 7 | |
| GSE54993 | ADAM18 | 8749 | 2 | 16 | 52 | |
| GSE54994 | ADAM18 | 8749 | 18 | 8 | 27 | |
| GSE60625 | ADAM18 | 8749 | 3 | 0 | 8 | |
| GSE74703 | ADAM18 | 8749 | 8 | 6 | 22 | |
| GSE74704 | ADAM18 | 8749 | 9 | 1 | 10 | |
| TCGA | ADAM18 | 8749 | 38 | 20 | 38 |
Total number of gains: 158; Total number of losses: 72; Total Number of normals: 258.
Somatic mutations of ADAM18:
Generating mutation plots.
Highly correlated genes for ADAM18:
Showing top 20/699 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAM18 | EDA2R | 0.730877 | 4 | 0 | 4 |
| ADAM18 | NXPE4 | 0.710439 | 4 | 0 | 4 |
| ADAM18 | NCR1 | 0.708337 | 4 | 0 | 4 |
| ADAM18 | BRINP2 | 0.692953 | 4 | 0 | 4 |
| ADAM18 | OR10H3 | 0.679844 | 6 | 0 | 5 |
| ADAM18 | RFPL2 | 0.676416 | 4 | 0 | 4 |
| ADAM18 | PLIN1 | 0.674012 | 3 | 0 | 3 |
| ADAM18 | GML | 0.668841 | 5 | 0 | 5 |
| ADAM18 | KIR3DL3 | 0.664189 | 4 | 0 | 4 |
| ADAM18 | IFNA17 | 0.663447 | 4 | 0 | 4 |
| ADAM18 | SLC5A5 | 0.662102 | 4 | 0 | 4 |
| ADAM18 | APOH | 0.662012 | 3 | 0 | 3 |
| ADAM18 | SLC17A3 | 0.660764 | 4 | 0 | 3 |
| ADAM18 | GAD2 | 0.660023 | 4 | 0 | 4 |
| ADAM18 | KCNMB2 | 0.659933 | 5 | 0 | 4 |
| ADAM18 | EPOR | 0.658368 | 4 | 0 | 4 |
| ADAM18 | PTPRN2 | 0.658171 | 3 | 0 | 3 |
| ADAM18 | CCZ1 | 0.657932 | 4 | 0 | 4 |
| ADAM18 | RUNX2 | 0.65592 | 4 | 0 | 4 |
| ADAM18 | TAS2R4 | 0.654898 | 4 | 0 | 3 |
For details and further investigation, click here
