| Full name: cone-rod homeobox | Alias Symbol: CRD|LCA7|OTX3 | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 1406 | HGNC ID: HGNC:2383 | Ensembl Gene: ENSG00000105392 | OMIM ID: 602225 |
| Drug and gene relationship at DGIdb | |||
Expression of CRX:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CRX | 1406 | 217510_at | -0.0954 | 0.6837 | |
| GSE20347 | CRX | 1406 | 217510_at | -0.1371 | 0.0236 | |
| GSE23400 | CRX | 1406 | 217510_at | -0.1655 | 0.0000 | |
| GSE26886 | CRX | 1406 | 217510_at | 0.2010 | 0.0620 | |
| GSE29001 | CRX | 1406 | 217510_at | -0.1388 | 0.3861 | |
| GSE38129 | CRX | 1406 | 217510_at | -0.1628 | 0.0212 | |
| GSE45670 | CRX | 1406 | 217510_at | -0.1792 | 0.0922 | |
| GSE53622 | CRX | 1406 | 99178 | -1.5826 | 0.0000 | |
| GSE53624 | CRX | 1406 | 99178 | -1.8659 | 0.0000 | |
| GSE63941 | CRX | 1406 | 217510_at | 0.0599 | 0.7601 | |
| GSE77861 | CRX | 1406 | 217510_at | -0.0354 | 0.7626 | |
| GSE97050 | CRX | 1406 | A_33_P3370707 | 0.0747 | 0.7086 | |
| SRP133303 | CRX | 1406 | RNAseq | -0.0855 | 0.7186 | |
| SRP193095 | CRX | 1406 | RNAseq | 0.1508 | 0.4788 | |
| TCGA | CRX | 1406 | RNAseq | 2.5740 | 0.0765 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CRX expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CRX:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CRX | 1406 | 4 | 4 | 22 | |
| GSE20123 | CRX | 1406 | 4 | 3 | 23 | |
| GSE43470 | CRX | 1406 | 3 | 10 | 30 | |
| GSE46452 | CRX | 1406 | 45 | 1 | 13 | |
| GSE47630 | CRX | 1406 | 8 | 7 | 25 | |
| GSE54993 | CRX | 1406 | 17 | 4 | 49 | |
| GSE54994 | CRX | 1406 | 4 | 14 | 35 | |
| GSE60625 | CRX | 1406 | 9 | 0 | 2 | |
| GSE74703 | CRX | 1406 | 3 | 7 | 26 | |
| GSE74704 | CRX | 1406 | 4 | 1 | 15 | |
| TCGA | CRX | 1406 | 15 | 18 | 63 |
Total number of gains: 116; Total number of losses: 69; Total Number of normals: 303.
Somatic mutations of CRX:
Generating mutation plots.
Highly correlated genes for CRX:
Showing top 20/705 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CRX | MTPN | 0.807255 | 3 | 0 | 3 |
| CRX | NTNG1 | 0.755424 | 5 | 0 | 4 |
| CRX | ITPRIP | 0.745735 | 4 | 0 | 4 |
| CRX | RSPH3 | 0.744066 | 3 | 0 | 3 |
| CRX | CASC3 | 0.743912 | 3 | 0 | 3 |
| CRX | ASH1L | 0.731217 | 3 | 0 | 3 |
| CRX | C15orf62 | 0.728547 | 3 | 0 | 3 |
| CRX | FAM47A | 0.723623 | 3 | 0 | 3 |
| CRX | KIAA0895L | 0.722769 | 3 | 0 | 3 |
| CRX | LACTBL1 | 0.720508 | 3 | 0 | 3 |
| CRX | SPTLC1 | 0.720015 | 3 | 0 | 3 |
| CRX | ATRNL1 | 0.717915 | 5 | 0 | 5 |
| CRX | OSBPL10 | 0.71493 | 4 | 0 | 4 |
| CRX | DIS3L2 | 0.713869 | 3 | 0 | 3 |
| CRX | LTA4H | 0.712059 | 3 | 0 | 3 |
| CRX | LZTS1 | 0.711332 | 4 | 0 | 3 |
| CRX | APOBEC1 | 0.711293 | 6 | 0 | 5 |
| CRX | EPS8L3 | 0.707858 | 5 | 0 | 5 |
| CRX | PNLIPRP2 | 0.705023 | 4 | 0 | 3 |
| CRX | RECK | 0.701391 | 3 | 0 | 3 |
For details and further investigation, click here
