| Full name: plasminogen | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6q26 | ||
| Entrez ID: 5340 | HGNC ID: HGNC:9071 | Ensembl Gene: ENSG00000122194 | OMIM ID: 173350 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PLG involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades | |
| hsa05150 | Staphylococcus aureus infection |
Expression of PLG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLG | 5340 | 240033_at | -0.0030 | 0.9928 | |
| GSE20347 | PLG | 5340 | 209977_at | -0.0252 | 0.7249 | |
| GSE23400 | PLG | 5340 | 209977_at | -0.0861 | 0.0132 | |
| GSE26886 | PLG | 5340 | 240033_at | 0.0171 | 0.8902 | |
| GSE29001 | PLG | 5340 | 209977_at | -0.0772 | 0.4629 | |
| GSE38129 | PLG | 5340 | 209977_at | -0.0404 | 0.5490 | |
| GSE45670 | PLG | 5340 | 240033_at | -0.0387 | 0.7744 | |
| GSE53622 | PLG | 5340 | 94827 | -0.6223 | 0.0000 | |
| GSE53624 | PLG | 5340 | 94827 | -0.3270 | 0.0007 | |
| GSE63941 | PLG | 5340 | 240033_at | 0.2757 | 0.1248 | |
| GSE77861 | PLG | 5340 | 240033_at | -0.0293 | 0.8473 | |
| GSE97050 | PLG | 5340 | A_23_P30693 | 0.4069 | 0.2918 | |
| SRP133303 | PLG | 5340 | RNAseq | 0.0794 | 0.7643 | |
| SRP159526 | PLG | 5340 | RNAseq | -0.0225 | 0.9666 | |
| SRP219564 | PLG | 5340 | RNAseq | 0.5150 | 0.2958 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PLG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLG | 5340 | 1 | 5 | 24 | |
| GSE20123 | PLG | 5340 | 1 | 4 | 25 | |
| GSE43470 | PLG | 5340 | 3 | 0 | 40 | |
| GSE46452 | PLG | 5340 | 3 | 10 | 46 | |
| GSE47630 | PLG | 5340 | 9 | 4 | 27 | |
| GSE54993 | PLG | 5340 | 4 | 4 | 62 | |
| GSE54994 | PLG | 5340 | 8 | 9 | 36 | |
| GSE60625 | PLG | 5340 | 0 | 1 | 10 | |
| GSE74703 | PLG | 5340 | 3 | 0 | 33 | |
| GSE74704 | PLG | 5340 | 0 | 2 | 18 | |
| TCGA | PLG | 5340 | 13 | 23 | 60 |
Total number of gains: 45; Total number of losses: 62; Total Number of normals: 381.
Somatic mutations of PLG:
Generating mutation plots.
Highly correlated genes for PLG:
Showing top 20/577 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLG | NEUROD4 | 0.677171 | 5 | 0 | 4 |
| PLG | MLC1 | 0.646768 | 3 | 0 | 3 |
| PLG | SLC28A2 | 0.645557 | 4 | 0 | 4 |
| PLG | NPAP1 | 0.638604 | 6 | 0 | 5 |
| PLG | SLC6A5 | 0.63732 | 4 | 0 | 4 |
| PLG | GP1BA | 0.635753 | 4 | 0 | 4 |
| PLG | PDX1 | 0.634485 | 4 | 0 | 4 |
| PLG | NPBWR1 | 0.633303 | 3 | 0 | 3 |
| PLG | MBL2 | 0.630918 | 3 | 0 | 3 |
| PLG | NTSR2 | 0.62871 | 4 | 0 | 4 |
| PLG | TCL1A | 0.627008 | 4 | 0 | 3 |
| PLG | PRM1 | 0.625367 | 5 | 0 | 4 |
| PLG | SLC16A8 | 0.625352 | 3 | 0 | 3 |
| PLG | PSG9 | 0.625028 | 3 | 0 | 3 |
| PLG | PRAMEF11 | 0.625024 | 7 | 0 | 6 |
| PLG | SLCO1A2 | 0.623031 | 4 | 0 | 4 |
| PLG | LINC00612 | 0.621565 | 3 | 0 | 3 |
| PLG | C8A | 0.621396 | 5 | 0 | 4 |
| PLG | RAI1 | 0.621099 | 5 | 0 | 4 |
| PLG | FCAR | 0.61832 | 5 | 0 | 4 |
For details and further investigation, click here
