| Full name: calcium voltage-gated channel auxiliary subunit gamma 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q24.2 | ||
| Entrez ID: 27091 | HGNC ID: HGNC:1409 | Ensembl Gene: ENSG00000075429 | OMIM ID: 606405 |
| Drug and gene relationship at DGIdb | |||
CACNG5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04261 | Adrenergic signaling in cardiomyocytes | |
| hsa04921 | Oxytocin signaling pathway |
Expression of CACNG5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CACNG5 | 27091 | 1552602_at | -0.1966 | 0.3774 | |
| GSE20347 | CACNG5 | 27091 | 221401_at | 0.1031 | 0.0891 | |
| GSE23400 | CACNG5 | 27091 | 221401_at | -0.1075 | 0.0099 | |
| GSE26886 | CACNG5 | 27091 | 221401_at | 0.1112 | 0.2985 | |
| GSE29001 | CACNG5 | 27091 | 221401_at | 0.0486 | 0.7283 | |
| GSE38129 | CACNG5 | 27091 | 221401_at | -0.0206 | 0.7766 | |
| GSE45670 | CACNG5 | 27091 | 1552602_at | 0.0250 | 0.8082 | |
| GSE53622 | CACNG5 | 27091 | 86174 | 0.2136 | 0.0792 | |
| GSE53624 | CACNG5 | 27091 | 86174 | 0.2343 | 0.1516 | |
| GSE63941 | CACNG5 | 27091 | 1552602_at | 0.1987 | 0.1226 | |
| GSE77861 | CACNG5 | 27091 | 221401_at | 0.0017 | 0.9872 | |
| SRP133303 | CACNG5 | 27091 | RNAseq | 0.1062 | 0.7343 | |
| SRP159526 | CACNG5 | 27091 | RNAseq | 1.2537 | 0.0037 | |
| SRP193095 | CACNG5 | 27091 | RNAseq | -0.1186 | 0.5741 | |
| SRP219564 | CACNG5 | 27091 | RNAseq | 0.5933 | 0.2458 | |
| TCGA | CACNG5 | 27091 | RNAseq | 1.2164 | 0.5887 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CACNG5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CACNG5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CACNG5 | 27091 | 3 | 2 | 25 | |
| GSE20123 | CACNG5 | 27091 | 3 | 2 | 25 | |
| GSE43470 | CACNG5 | 27091 | 5 | 0 | 38 | |
| GSE46452 | CACNG5 | 27091 | 31 | 1 | 27 | |
| GSE47630 | CACNG5 | 27091 | 7 | 1 | 32 | |
| GSE54993 | CACNG5 | 27091 | 2 | 5 | 63 | |
| GSE54994 | CACNG5 | 27091 | 9 | 4 | 40 | |
| GSE60625 | CACNG5 | 27091 | 4 | 2 | 5 | |
| GSE74703 | CACNG5 | 27091 | 5 | 0 | 31 | |
| GSE74704 | CACNG5 | 27091 | 3 | 1 | 16 | |
| TCGA | CACNG5 | 27091 | 28 | 9 | 59 |
Total number of gains: 100; Total number of losses: 27; Total Number of normals: 361.
Somatic mutations of CACNG5:
Generating mutation plots.
Highly correlated genes for CACNG5:
Showing top 20/665 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CACNG5 | PF4 | 0.706691 | 3 | 0 | 3 |
| CACNG5 | RAB4B | 0.688581 | 3 | 0 | 3 |
| CACNG5 | CCL24 | 0.685009 | 4 | 0 | 4 |
| CACNG5 | NMNAT2 | 0.68407 | 3 | 0 | 3 |
| CACNG5 | KIR3DL3 | 0.678873 | 4 | 0 | 4 |
| CACNG5 | LRRTM2 | 0.675902 | 3 | 0 | 3 |
| CACNG5 | MAPK4 | 0.669668 | 5 | 0 | 5 |
| CACNG5 | ADCYAP1 | 0.668891 | 3 | 0 | 3 |
| CACNG5 | ADAM21 | 0.66858 | 4 | 0 | 4 |
| CACNG5 | LMNTD1 | 0.662482 | 3 | 0 | 3 |
| CACNG5 | ELMOD3 | 0.659101 | 3 | 0 | 3 |
| CACNG5 | LILRA3 | 0.657016 | 4 | 0 | 3 |
| CACNG5 | CNR2 | 0.656196 | 6 | 0 | 5 |
| CACNG5 | XPNPEP2 | 0.656141 | 4 | 0 | 4 |
| CACNG5 | SOAT2 | 0.654572 | 4 | 0 | 3 |
| CACNG5 | RHPN1-AS1 | 0.654538 | 3 | 0 | 3 |
| CACNG5 | KCNV1 | 0.650662 | 3 | 0 | 3 |
| CACNG5 | P2RX6 | 0.649903 | 4 | 0 | 3 |
| CACNG5 | OR1F1 | 0.648693 | 6 | 0 | 6 |
| CACNG5 | DIO3 | 0.648445 | 4 | 0 | 3 |
For details and further investigation, click here
