| Full name: collagen type IV alpha 3 chain | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q36.3 | ||
| Entrez ID: 1285 | HGNC ID: HGNC:2204 | Ensembl Gene: ENSG00000169031 | OMIM ID: 120070 |
| Drug and gene relationship at DGIdb | |||
COL4A3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa05200 | Pathways in cancer | |
| hsa05222 | Small cell lung cancer |
Expression of COL4A3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COL4A3 | 1285 | 222073_at | -0.5717 | 0.5845 | |
| GSE20347 | COL4A3 | 1285 | 214641_at | -0.0802 | 0.2860 | |
| GSE23400 | COL4A3 | 1285 | 216368_s_at | -0.0683 | 0.0132 | |
| GSE26886 | COL4A3 | 1285 | 214641_at | -0.0142 | 0.8928 | |
| GSE29001 | COL4A3 | 1285 | 214641_at | -0.0572 | 0.7105 | |
| GSE38129 | COL4A3 | 1285 | 214641_at | -0.1878 | 0.0131 | |
| GSE45670 | COL4A3 | 1285 | 214641_at | -0.0681 | 0.6147 | |
| GSE63941 | COL4A3 | 1285 | 214641_at | 0.0171 | 0.9542 | |
| GSE77861 | COL4A3 | 1285 | 214641_at | -0.0976 | 0.4371 | |
| SRP064894 | COL4A3 | 1285 | RNAseq | -0.9176 | 0.0411 | |
| SRP133303 | COL4A3 | 1285 | RNAseq | -0.8468 | 0.0711 | |
| SRP159526 | COL4A3 | 1285 | RNAseq | -1.5687 | 0.0120 | |
| TCGA | COL4A3 | 1285 | RNAseq | -1.7629 | 0.0011 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by COL4A3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of COL4A3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COL4A3 | 1285 | 2 | 12 | 16 | |
| GSE20123 | COL4A3 | 1285 | 2 | 12 | 16 | |
| GSE43470 | COL4A3 | 1285 | 0 | 7 | 36 | |
| GSE46452 | COL4A3 | 1285 | 0 | 5 | 54 | |
| GSE47630 | COL4A3 | 1285 | 4 | 5 | 31 | |
| GSE54993 | COL4A3 | 1285 | 1 | 2 | 67 | |
| GSE54994 | COL4A3 | 1285 | 6 | 11 | 36 | |
| GSE60625 | COL4A3 | 1285 | 0 | 3 | 8 | |
| GSE74703 | COL4A3 | 1285 | 0 | 6 | 30 | |
| GSE74704 | COL4A3 | 1285 | 2 | 6 | 12 | |
| TCGA | COL4A3 | 1285 | 13 | 26 | 57 |
Total number of gains: 30; Total number of losses: 95; Total Number of normals: 363.
Somatic mutations of COL4A3:
Generating mutation plots.
Highly correlated genes for COL4A3:
Showing top 20/675 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COL4A3 | CALCB | 0.748533 | 3 | 0 | 3 |
| COL4A3 | MAGEA8 | 0.722789 | 3 | 0 | 3 |
| COL4A3 | GPR35 | 0.706138 | 4 | 0 | 4 |
| COL4A3 | GRM6 | 0.689502 | 4 | 0 | 4 |
| COL4A3 | PRR34 | 0.685448 | 5 | 0 | 4 |
| COL4A3 | IAPP | 0.681473 | 3 | 0 | 3 |
| COL4A3 | MYH8 | 0.67777 | 3 | 0 | 3 |
| COL4A3 | RNF17 | 0.671075 | 4 | 0 | 4 |
| COL4A3 | NCR3 | 0.670946 | 3 | 0 | 3 |
| COL4A3 | G6PC2 | 0.670766 | 5 | 0 | 5 |
| COL4A3 | KRTAP5-8 | 0.670753 | 4 | 0 | 4 |
| COL4A3 | SLC22A2 | 0.669703 | 5 | 0 | 4 |
| COL4A3 | GCNT4 | 0.669021 | 5 | 0 | 4 |
| COL4A3 | GYPB | 0.664885 | 4 | 0 | 4 |
| COL4A3 | SCN7A | 0.661893 | 3 | 0 | 3 |
| COL4A3 | PRLR | 0.654503 | 4 | 0 | 3 |
| COL4A3 | HLA-DOA | 0.653543 | 5 | 0 | 5 |
| COL4A3 | ADAM22 | 0.652882 | 4 | 0 | 3 |
| COL4A3 | KLHL35 | 0.652146 | 3 | 0 | 3 |
| COL4A3 | NTNG1 | 0.65085 | 4 | 0 | 3 |
For details and further investigation, click here
