PLCB2

 

Full name: phospholipase C beta 2 Alias Symbol: FLJ38135
Type: protein-coding gene Cytoband: 15q15.1
Entrez ID: 5330 HGNC ID: HGNC:9055 Ensembl Gene: ENSG00000137841 OMIM ID: 604114
Drug and gene relationship at DGIdb

 

PLCB2 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04062Chemokine signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04742Taste transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04973Carbohydrate digestion and absorption
hsa05010Alzheimer's disease
hsa05016Huntington's disease
hsa05142Chagas disease (American trypanosomiasis)

 

Expression of PLCB2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PLCB2 5330 204046_at 0.2395 0.5871
GSE20347 PLCB2 5330 204046_at 0.0372 0.7257
GSE23400 PLCB2 5330 204046_at -0.1824 0.0000
GSE26886 PLCB2 5330 204046_at 0.1536 0.2550
GSE29001 PLCB2 5330 204046_at -0.2136 0.3086
GSE38129 PLCB2 5330 204046_at -0.1057 0.2282
GSE45670 PLCB2 5330 204046_at 0.0084 0.9283
GSE53622 PLCB2 5330 118756 0.0552 0.7791
GSE53624 PLCB2 5330 118756 0.1281 0.2954
GSE63941 PLCB2 5330 204046_at 0.1430 0.4901
GSE77861 PLCB2 5330 204046_at 0.1251 0.4939
GSE97050 PLCB2 5330 A_33_P3260614 0.4321 0.1726
SRP007169 PLCB2 5330 RNAseq 1.4729 0.0770
SRP064894 PLCB2 5330 RNAseq 0.4903 0.1526
SRP133303 PLCB2 5330 RNAseq -0.2727 0.2522
SRP159526 PLCB2 5330 RNAseq -0.6667 0.1965
SRP193095 PLCB2 5330 RNAseq 0.0716 0.7757
SRP219564 PLCB2 5330 RNAseq 0.7191 0.0416
TCGA PLCB2 5330 RNAseq 0.0964 0.4794

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PLCB2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PLCB2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PLCB2 5330 4 5 21
GSE20123 PLCB2 5330 4 5 21
GSE43470 PLCB2 5330 4 6 33
GSE46452 PLCB2 5330 3 7 49
GSE47630 PLCB2 5330 8 11 21
GSE54993 PLCB2 5330 4 6 60
GSE54994 PLCB2 5330 5 7 41
GSE60625 PLCB2 5330 4 0 7
GSE74703 PLCB2 5330 4 5 27
GSE74704 PLCB2 5330 3 3 14
TCGA PLCB2 5330 11 17 68

Total number of gains: 54; Total number of losses: 72; Total Number of normals: 362.  

 

Somatic mutations of PLCB2:

 

Generating mutation plots.

 

Highly correlated genes for PLCB2:

 

Showing top 20/827 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PLCB2SNX200.816321404
PLCB2GRAMD1A0.778219303
PLCB2PA2G40.774413303
PLCB2LCP20.770988404
PLCB2C19orf380.770768303
PLCB2CORO1A0.766173505
PLCB2NCKAP1L0.765761707
PLCB2GPR650.764008404
PLCB2TMEM2140.760498403
PLCB2PREX10.758658404
PLCB2TNFSF130.75269303
PLCB2CD163L10.751023303
PLCB2AOAH0.750703404
PLCB2ARHGAP90.741221605
PLCB2SETD1A0.738959403
PLCB2PARVG0.738364605
PLCB2ADAM150.73188303
PLCB2TAGAP0.731087504
PLCB2C1QA0.730166505
PLCB2PSMB8-AS10.728778303

For details and further investigation, click here