| Full name: glutamate metabotropic receptor 2 | Alias Symbol: GPRC1B|mGlu2|MGLUR2 | ||
| Type: protein-coding gene | Cytoband: 3p21.2 | ||
| Entrez ID: 2912 | HGNC ID: HGNC:4594 | Ensembl Gene: ENSG00000164082 | OMIM ID: 604099 |
| Drug and gene relationship at DGIdb | |||
GRM2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04072 | Phospholipase D signaling pathway | |
| hsa04724 | Glutamatergic synapse | |
| hsa05030 | Cocaine addiction |
Expression of GRM2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRM2 | 2912 | 241802_x_at | 0.0173 | 0.9460 | |
| GSE20347 | GRM2 | 2912 | 208465_at | -0.1444 | 0.0942 | |
| GSE23400 | GRM2 | 2912 | 208465_at | -0.1394 | 0.0002 | |
| GSE26886 | GRM2 | 2912 | 241802_x_at | 0.1146 | 0.3419 | |
| GSE29001 | GRM2 | 2912 | 208465_at | -0.0855 | 0.6611 | |
| GSE38129 | GRM2 | 2912 | 208465_at | -0.2291 | 0.0067 | |
| GSE45670 | GRM2 | 2912 | 241802_x_at | 0.1354 | 0.1373 | |
| GSE63941 | GRM2 | 2912 | 241802_x_at | 0.1259 | 0.4176 | |
| GSE77861 | GRM2 | 2912 | 241802_x_at | -0.1808 | 0.1913 | |
| SRP219564 | GRM2 | 2912 | RNAseq | 1.3760 | 0.0049 | |
| TCGA | GRM2 | 2912 | RNAseq | -0.6698 | 0.0090 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GRM2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GRM2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRM2 | 2912 | 0 | 18 | 12 | |
| GSE20123 | GRM2 | 2912 | 0 | 19 | 11 | |
| GSE43470 | GRM2 | 2912 | 0 | 18 | 25 | |
| GSE46452 | GRM2 | 2912 | 2 | 17 | 40 | |
| GSE47630 | GRM2 | 2912 | 1 | 24 | 15 | |
| GSE54993 | GRM2 | 2912 | 6 | 2 | 62 | |
| GSE54994 | GRM2 | 2912 | 0 | 34 | 19 | |
| GSE60625 | GRM2 | 2912 | 5 | 0 | 6 | |
| GSE74703 | GRM2 | 2912 | 0 | 14 | 22 | |
| GSE74704 | GRM2 | 2912 | 0 | 12 | 8 | |
| TCGA | GRM2 | 2912 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 236; Total Number of normals: 238.
Somatic mutations of GRM2:
Generating mutation plots.
Highly correlated genes for GRM2:
Showing top 20/938 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRM2 | OVGP1 | 0.745464 | 3 | 0 | 3 |
| GRM2 | ATF7 | 0.726959 | 3 | 0 | 3 |
| GRM2 | DRICH1 | 0.713097 | 4 | 0 | 4 |
| GRM2 | INCENP | 0.711434 | 3 | 0 | 3 |
| GRM2 | KSR1 | 0.709622 | 3 | 0 | 3 |
| GRM2 | PGC | 0.706291 | 4 | 0 | 4 |
| GRM2 | MYH8 | 0.704138 | 3 | 0 | 3 |
| GRM2 | KLK14 | 0.703267 | 4 | 0 | 4 |
| GRM2 | NTNG1 | 0.684632 | 4 | 0 | 4 |
| GRM2 | SLC5A5 | 0.679173 | 5 | 0 | 4 |
| GRM2 | APCS | 0.677931 | 3 | 0 | 3 |
| GRM2 | CCDC7 | 0.674055 | 4 | 0 | 4 |
| GRM2 | KLF15 | 0.673893 | 4 | 0 | 4 |
| GRM2 | TEX15 | 0.673174 | 3 | 0 | 3 |
| GRM2 | C4BPB | 0.670287 | 5 | 0 | 4 |
| GRM2 | MVK | 0.669678 | 5 | 0 | 5 |
| GRM2 | OR6A2 | 0.669265 | 4 | 0 | 3 |
| GRM2 | LYPLA2 | 0.665633 | 3 | 0 | 3 |
| GRM2 | OPRL1 | 0.663661 | 5 | 0 | 4 |
| GRM2 | TAAR5 | 0.659647 | 5 | 0 | 4 |
For details and further investigation, click here
