| Full name: myosin light chain 7 | Alias Symbol: MYLC2A|MYL2A | ||
| Type: protein-coding gene | Cytoband: 7p13 | ||
| Entrez ID: 58498 | HGNC ID: HGNC:21719 | Ensembl Gene: ENSG00000106631 | OMIM ID: 613993 |
| Drug and gene relationship at DGIdb | |||
MYL7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04510 | Focal adhesion | |
| hsa04530 | Tight junction | |
| hsa04670 | Leukocyte transendothelial migration | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of MYL7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYL7 | 58498 | 219942_at | -0.1179 | 0.6428 | |
| GSE20347 | MYL7 | 58498 | 219942_at | -0.0869 | 0.1681 | |
| GSE23400 | MYL7 | 58498 | 219942_at | -0.1700 | 0.0004 | |
| GSE26886 | MYL7 | 58498 | 219942_at | 0.1476 | 0.3089 | |
| GSE29001 | MYL7 | 58498 | 219942_at | -0.2502 | 0.0558 | |
| GSE38129 | MYL7 | 58498 | 219942_at | -0.1403 | 0.0730 | |
| GSE45670 | MYL7 | 58498 | 219942_at | -0.0036 | 0.9748 | |
| GSE53622 | MYL7 | 58498 | 19243 | -0.0963 | 0.3121 | |
| GSE53624 | MYL7 | 58498 | 19243 | -0.2619 | 0.0468 | |
| GSE63941 | MYL7 | 58498 | 219942_at | 0.2907 | 0.1397 | |
| GSE77861 | MYL7 | 58498 | 219942_at | -0.1141 | 0.2965 | |
| GSE97050 | MYL7 | 58498 | A_23_P59738 | -0.8539 | 0.1005 | |
| TCGA | MYL7 | 58498 | RNAseq | 1.9052 | 0.5637 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MYL7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYL7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYL7 | 58498 | 14 | 0 | 16 | |
| GSE20123 | MYL7 | 58498 | 13 | 0 | 17 | |
| GSE43470 | MYL7 | 58498 | 4 | 0 | 39 | |
| GSE46452 | MYL7 | 58498 | 11 | 1 | 47 | |
| GSE47630 | MYL7 | 58498 | 8 | 1 | 31 | |
| GSE54993 | MYL7 | 58498 | 0 | 8 | 62 | |
| GSE54994 | MYL7 | 58498 | 17 | 3 | 33 | |
| GSE60625 | MYL7 | 58498 | 0 | 0 | 11 | |
| GSE74703 | MYL7 | 58498 | 4 | 0 | 32 | |
| GSE74704 | MYL7 | 58498 | 7 | 0 | 13 | |
| TCGA | MYL7 | 58498 | 51 | 7 | 38 |
Total number of gains: 129; Total number of losses: 20; Total Number of normals: 339.
Somatic mutations of MYL7:
Generating mutation plots.
Highly correlated genes for MYL7:
Showing top 20/817 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYL7 | STRC | 0.762141 | 3 | 0 | 3 |
| MYL7 | LINC01122 | 0.759714 | 3 | 0 | 3 |
| MYL7 | PLA2G2C | 0.757772 | 3 | 0 | 3 |
| MYL7 | KIF19 | 0.756956 | 3 | 0 | 3 |
| MYL7 | C2orf50 | 0.752939 | 3 | 0 | 3 |
| MYL7 | CDRT15 | 0.744073 | 5 | 0 | 4 |
| MYL7 | SAMD4A | 0.743263 | 4 | 0 | 4 |
| MYL7 | MALRD1 | 0.740516 | 3 | 0 | 3 |
| MYL7 | DCDC1 | 0.730244 | 3 | 0 | 3 |
| MYL7 | TATDN3 | 0.729847 | 3 | 0 | 3 |
| MYL7 | TTC34 | 0.729463 | 3 | 0 | 3 |
| MYL7 | PTAFR | 0.718616 | 5 | 0 | 5 |
| MYL7 | ZNF527 | 0.718439 | 3 | 0 | 3 |
| MYL7 | TSPAN10 | 0.718266 | 4 | 0 | 4 |
| MYL7 | PPP1R12C | 0.709334 | 3 | 0 | 3 |
| MYL7 | RAX | 0.707698 | 6 | 0 | 6 |
| MYL7 | PRAMEF12 | 0.704556 | 4 | 0 | 4 |
| MYL7 | OR2T27 | 0.703424 | 3 | 0 | 3 |
| MYL7 | C2CD4D | 0.698016 | 3 | 0 | 3 |
| MYL7 | C20orf85 | 0.694871 | 3 | 0 | 3 |
For details and further investigation, click here
