| Full name: nescient helix-loop-helix 2 | Alias Symbol: NSCL2|bHLHa34 | ||
| Type: protein-coding gene | Cytoband: 1p13.1 | ||
| Entrez ID: 4808 | HGNC ID: HGNC:7818 | Ensembl Gene: ENSG00000177551 | OMIM ID: 162361 |
| Drug and gene relationship at DGIdb | |||
Expression of NHLH2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NHLH2 | 4808 | 215228_at | -2.0424 | 0.0086 | |
| GSE20347 | NHLH2 | 4808 | 215228_at | -1.5205 | 0.0000 | |
| GSE23400 | NHLH2 | 4808 | 215228_at | -0.2863 | 0.0007 | |
| GSE26886 | NHLH2 | 4808 | 215228_at | -2.5406 | 0.0000 | |
| GSE29001 | NHLH2 | 4808 | 215228_at | -1.4883 | 0.0224 | |
| GSE38129 | NHLH2 | 4808 | 215228_at | -0.9387 | 0.0056 | |
| GSE45670 | NHLH2 | 4808 | 215228_at | -1.0392 | 0.0660 | |
| GSE53622 | NHLH2 | 4808 | 10287 | -0.0542 | 0.5411 | |
| GSE53624 | NHLH2 | 4808 | 10287 | 0.1268 | 0.2760 | |
| GSE63941 | NHLH2 | 4808 | 214497_s_at | 0.1427 | 0.4538 | |
| GSE77861 | NHLH2 | 4808 | 215228_at | -0.3213 | 0.2990 | |
| GSE97050 | NHLH2 | 4808 | A_33_P3231252 | -0.1392 | 0.7959 | |
| SRP064894 | NHLH2 | 4808 | RNAseq | -0.5983 | 0.2161 | |
| SRP133303 | NHLH2 | 4808 | RNAseq | -0.7668 | 0.0866 | |
| SRP159526 | NHLH2 | 4808 | RNAseq | -1.4131 | 0.0636 | |
| TCGA | NHLH2 | 4808 | RNAseq | 2.0583 | 0.0015 |
Upregulated datasets: 1; Downregulated datasets: 4.
Survival by NHLH2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NHLH2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NHLH2 | 4808 | 0 | 9 | 21 | |
| GSE20123 | NHLH2 | 4808 | 0 | 9 | 21 | |
| GSE43470 | NHLH2 | 4808 | 0 | 7 | 36 | |
| GSE46452 | NHLH2 | 4808 | 2 | 1 | 56 | |
| GSE47630 | NHLH2 | 4808 | 9 | 5 | 26 | |
| GSE54993 | NHLH2 | 4808 | 0 | 1 | 69 | |
| GSE54994 | NHLH2 | 4808 | 8 | 3 | 42 | |
| GSE60625 | NHLH2 | 4808 | 0 | 0 | 11 | |
| GSE74703 | NHLH2 | 4808 | 0 | 6 | 30 | |
| GSE74704 | NHLH2 | 4808 | 0 | 5 | 15 | |
| TCGA | NHLH2 | 4808 | 14 | 28 | 54 |
Total number of gains: 33; Total number of losses: 74; Total Number of normals: 381.
Somatic mutations of NHLH2:
Generating mutation plots.
Highly correlated genes for NHLH2:
Showing top 20/919 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NHLH2 | KRTAP12-2 | 0.822625 | 3 | 0 | 3 |
| NHLH2 | TMEM150A | 0.813096 | 3 | 0 | 3 |
| NHLH2 | TMPRSS11B | 0.811226 | 3 | 0 | 3 |
| NHLH2 | BNIPL | 0.762864 | 3 | 0 | 3 |
| NHLH2 | C15orf62 | 0.762443 | 4 | 0 | 4 |
| NHLH2 | VSIG10L | 0.758955 | 3 | 0 | 3 |
| NHLH2 | SLC16A14 | 0.748739 | 3 | 0 | 3 |
| NHLH2 | SFTA2 | 0.747273 | 3 | 0 | 3 |
| NHLH2 | SLC30A4 | 0.740332 | 4 | 0 | 4 |
| NHLH2 | SMIM5 | 0.74022 | 3 | 0 | 3 |
| NHLH2 | CHMP2A | 0.739794 | 6 | 0 | 6 |
| NHLH2 | A2ML1 | 0.739642 | 3 | 0 | 3 |
| NHLH2 | CYSRT1 | 0.736613 | 3 | 0 | 3 |
| NHLH2 | PARD3 | 0.732132 | 3 | 0 | 3 |
| NHLH2 | HCG22 | 0.728767 | 3 | 0 | 3 |
| NHLH2 | GTF3C6 | 0.727338 | 3 | 0 | 3 |
| NHLH2 | SLC22A15 | 0.727209 | 6 | 0 | 5 |
| NHLH2 | OXNAD1 | 0.725656 | 3 | 0 | 3 |
| NHLH2 | ULK3 | 0.724083 | 4 | 0 | 4 |
| NHLH2 | CAPNS2 | 0.722615 | 4 | 0 | 4 |
For details and further investigation, click here
