| Full name: transmembrane serine protease 11B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q13.2 | ||
| Entrez ID: 132724 | HGNC ID: HGNC:25398 | Ensembl Gene: ENSG00000185873 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of TMPRSS11B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMPRSS11B | 132724 | 1560712_at | -5.8157 | 0.0151 | |
| GSE26886 | TMPRSS11B | 132724 | 1560712_at | -9.3211 | 0.0000 | |
| GSE45670 | TMPRSS11B | 132724 | 1560712_at | -2.3115 | 0.0228 | |
| GSE53622 | TMPRSS11B | 132724 | 51025 | -3.9992 | 0.0000 | |
| GSE53624 | TMPRSS11B | 132724 | 51025 | -4.7767 | 0.0000 | |
| GSE63941 | TMPRSS11B | 132724 | 1560712_at | -0.1099 | 0.3591 | |
| GSE77861 | TMPRSS11B | 132724 | 1560712_at | -4.5143 | 0.0137 | |
| GSE97050 | TMPRSS11B | 132724 | A_33_P3318097 | -3.4994 | 0.0867 | |
| SRP007169 | TMPRSS11B | 132724 | RNAseq | -8.4195 | 0.0000 | |
| SRP008496 | TMPRSS11B | 132724 | RNAseq | -8.1962 | 0.0000 | |
| SRP064894 | TMPRSS11B | 132724 | RNAseq | -5.2972 | 0.0000 | |
| SRP133303 | TMPRSS11B | 132724 | RNAseq | -6.4937 | 0.0000 | |
| SRP159526 | TMPRSS11B | 132724 | RNAseq | -7.2900 | 0.0000 | |
| SRP193095 | TMPRSS11B | 132724 | RNAseq | -5.6200 | 0.0000 | |
| SRP219564 | TMPRSS11B | 132724 | RNAseq | -6.1428 | 0.0000 | |
| TCGA | TMPRSS11B | 132724 | RNAseq | -0.3397 | 0.6788 |
Upregulated datasets: 0; Downregulated datasets: 13.
Survival by TMPRSS11B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMPRSS11B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMPRSS11B | 132724 | 2 | 11 | 17 | |
| GSE20123 | TMPRSS11B | 132724 | 2 | 12 | 16 | |
| GSE43470 | TMPRSS11B | 132724 | 0 | 13 | 30 | |
| GSE46452 | TMPRSS11B | 132724 | 2 | 35 | 22 | |
| GSE47630 | TMPRSS11B | 132724 | 0 | 20 | 20 | |
| GSE54993 | TMPRSS11B | 132724 | 7 | 0 | 63 | |
| GSE54994 | TMPRSS11B | 132724 | 1 | 9 | 43 | |
| GSE60625 | TMPRSS11B | 132724 | 0 | 0 | 11 | |
| GSE74703 | TMPRSS11B | 132724 | 0 | 11 | 25 | |
| GSE74704 | TMPRSS11B | 132724 | 1 | 8 | 11 | |
| TCGA | TMPRSS11B | 132724 | 18 | 26 | 52 |
Total number of gains: 33; Total number of losses: 145; Total Number of normals: 310.
Somatic mutations of TMPRSS11B:
Generating mutation plots.
Highly correlated genes for TMPRSS11B:
Showing top 20/1578 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMPRSS11B | CRNN | 0.955733 | 8 | 0 | 8 |
| TMPRSS11B | MAL | 0.939487 | 8 | 0 | 8 |
| TMPRSS11B | SPINK5 | 0.933219 | 8 | 0 | 8 |
| TMPRSS11B | CLCA4 | 0.932591 | 8 | 0 | 8 |
| TMPRSS11B | SCEL | 0.917873 | 8 | 0 | 8 |
| TMPRSS11B | CAPN14 | 0.913044 | 7 | 0 | 7 |
| TMPRSS11B | PRSS27 | 0.912042 | 8 | 0 | 8 |
| TMPRSS11B | TGM3 | 0.910449 | 8 | 0 | 8 |
| TMPRSS11B | SPINK7 | 0.910208 | 8 | 0 | 8 |
| TMPRSS11B | MUC21 | 0.909183 | 3 | 0 | 3 |
| TMPRSS11B | KRT78 | 0.907653 | 8 | 0 | 8 |
| TMPRSS11B | TMPRSS11E | 0.906338 | 7 | 0 | 7 |
| TMPRSS11B | VSIG10L | 0.89894 | 7 | 0 | 7 |
| TMPRSS11B | SLURP1 | 0.897672 | 8 | 0 | 8 |
| TMPRSS11B | A2ML1 | 0.891968 | 8 | 0 | 8 |
| TMPRSS11B | ENDOU | 0.889486 | 7 | 0 | 7 |
| TMPRSS11B | IL36A | 0.887987 | 7 | 0 | 7 |
| TMPRSS11B | SLC16A6 | 0.886411 | 6 | 0 | 6 |
| TMPRSS11B | EMP1 | 0.876706 | 8 | 0 | 8 |
| TMPRSS11B | FAM214A | 0.875334 | 6 | 0 | 6 |
For details and further investigation, click here
