| Full name: charged multivesicular body protein 2A | Alias Symbol: BC-2|CHMP2|VPS2|VPS2A | ||
| Type: protein-coding gene | Cytoband: 19q13.43 | ||
| Entrez ID: 27243 | HGNC ID: HGNC:30216 | Ensembl Gene: ENSG00000130724 | OMIM ID: 610893 |
| Drug and gene relationship at DGIdb | |||
Expression of CHMP2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHMP2A | 27243 | 202121_s_at | -0.5443 | 0.0374 | |
| GSE20347 | CHMP2A | 27243 | 202121_s_at | -1.0180 | 0.0000 | |
| GSE23400 | CHMP2A | 27243 | 202121_s_at | -0.6562 | 0.0000 | |
| GSE26886 | CHMP2A | 27243 | 202121_s_at | -0.8043 | 0.0000 | |
| GSE29001 | CHMP2A | 27243 | 202121_s_at | -0.9983 | 0.0244 | |
| GSE38129 | CHMP2A | 27243 | 202121_s_at | -0.6771 | 0.0000 | |
| GSE45670 | CHMP2A | 27243 | 202121_s_at | -0.3240 | 0.0345 | |
| GSE53622 | CHMP2A | 27243 | 101648 | -0.6561 | 0.0000 | |
| GSE53624 | CHMP2A | 27243 | 101648 | -0.5940 | 0.0000 | |
| GSE63941 | CHMP2A | 27243 | 202121_s_at | -0.4308 | 0.4354 | |
| GSE77861 | CHMP2A | 27243 | 202121_s_at | -0.5498 | 0.0242 | |
| GSE97050 | CHMP2A | 27243 | A_23_P153236 | -0.4568 | 0.1075 | |
| SRP007169 | CHMP2A | 27243 | RNAseq | -1.7726 | 0.0003 | |
| SRP008496 | CHMP2A | 27243 | RNAseq | -1.4535 | 0.0000 | |
| SRP064894 | CHMP2A | 27243 | RNAseq | -0.2130 | 0.5081 | |
| SRP133303 | CHMP2A | 27243 | RNAseq | -0.4554 | 0.0489 | |
| SRP159526 | CHMP2A | 27243 | RNAseq | -0.4309 | 0.0223 | |
| SRP193095 | CHMP2A | 27243 | RNAseq | -0.7383 | 0.0000 | |
| SRP219564 | CHMP2A | 27243 | RNAseq | -0.6512 | 0.0023 | |
| TCGA | CHMP2A | 27243 | RNAseq | -0.1076 | 0.0893 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CHMP2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHMP2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHMP2A | 27243 | 2 | 5 | 23 | |
| GSE20123 | CHMP2A | 27243 | 2 | 4 | 24 | |
| GSE43470 | CHMP2A | 27243 | 3 | 9 | 31 | |
| GSE46452 | CHMP2A | 27243 | 45 | 1 | 13 | |
| GSE47630 | CHMP2A | 27243 | 7 | 6 | 27 | |
| GSE54993 | CHMP2A | 27243 | 18 | 4 | 48 | |
| GSE54994 | CHMP2A | 27243 | 5 | 12 | 36 | |
| GSE60625 | CHMP2A | 27243 | 9 | 0 | 2 | |
| GSE74703 | CHMP2A | 27243 | 3 | 6 | 27 | |
| GSE74704 | CHMP2A | 27243 | 2 | 1 | 17 | |
| TCGA | CHMP2A | 27243 | 20 | 19 | 57 |
Total number of gains: 116; Total number of losses: 67; Total Number of normals: 305.
Somatic mutations of CHMP2A:
Generating mutation plots.
Highly correlated genes for CHMP2A:
Showing top 20/1692 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHMP2A | SYTL4 | 0.779224 | 3 | 0 | 3 |
| CHMP2A | NAGK | 0.775552 | 11 | 0 | 11 |
| CHMP2A | NECAP2 | 0.774856 | 3 | 0 | 3 |
| CHMP2A | ESYT2 | 0.773065 | 5 | 0 | 5 |
| CHMP2A | FAM71C | 0.772266 | 3 | 0 | 3 |
| CHMP2A | UBQLN1 | 0.76788 | 3 | 0 | 3 |
| CHMP2A | FCHO2 | 0.765911 | 7 | 0 | 7 |
| CHMP2A | FAM214A | 0.76349 | 6 | 0 | 6 |
| CHMP2A | RMND5B | 0.760234 | 11 | 0 | 11 |
| CHMP2A | CCNYL1 | 0.759126 | 4 | 0 | 4 |
| CHMP2A | CTTNBP2NL | 0.756516 | 7 | 0 | 7 |
| CHMP2A | PEX2 | 0.754312 | 3 | 0 | 3 |
| CHMP2A | FAM219B | 0.753099 | 3 | 0 | 3 |
| CHMP2A | GGA3 | 0.751647 | 4 | 0 | 4 |
| CHMP2A | FAM3D | 0.750799 | 6 | 0 | 6 |
| CHMP2A | SNORA68 | 0.749793 | 4 | 0 | 4 |
| CHMP2A | ZFAND2B | 0.74816 | 7 | 0 | 7 |
| CHMP2A | SRP68 | 0.745667 | 3 | 0 | 3 |
| CHMP2A | TP53INP2 | 0.745217 | 6 | 0 | 6 |
| CHMP2A | MAML2 | 0.74458 | 3 | 0 | 3 |
For details and further investigation, click here
