| Full name: alpha-2-macroglobulin like 1 | Alias Symbol: FLJ25179|p170 | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 144568 | HGNC ID: HGNC:23336 | Ensembl Gene: ENSG00000166535 | OMIM ID: 610627 |
| Drug and gene relationship at DGIdb | |||
Expression of A2ML1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | A2ML1 | 144568 | 1564307_a_at | -3.4974 | 0.0666 | |
| GSE26886 | A2ML1 | 144568 | 1564307_a_at | -5.9207 | 0.0000 | |
| GSE45670 | A2ML1 | 144568 | 1564307_a_at | -1.5674 | 0.0016 | |
| GSE53622 | A2ML1 | 144568 | 137127 | -3.0609 | 0.0000 | |
| GSE53624 | A2ML1 | 144568 | 137127 | -3.5031 | 0.0000 | |
| GSE63941 | A2ML1 | 144568 | 1553505_at | 0.0614 | 0.6874 | |
| GSE77861 | A2ML1 | 144568 | 1564307_a_at | -3.1090 | 0.0033 | |
| GSE97050 | A2ML1 | 144568 | A_33_P3525263 | -1.9243 | 0.1556 | |
| SRP007169 | A2ML1 | 144568 | RNAseq | -5.1987 | 0.0000 | |
| SRP008496 | A2ML1 | 144568 | RNAseq | -4.9259 | 0.0000 | |
| SRP064894 | A2ML1 | 144568 | RNAseq | -5.2833 | 0.0000 | |
| SRP133303 | A2ML1 | 144568 | RNAseq | -4.5945 | 0.0000 | |
| SRP159526 | A2ML1 | 144568 | RNAseq | -6.3067 | 0.0000 | |
| SRP219564 | A2ML1 | 144568 | RNAseq | -4.6361 | 0.0008 | |
| TCGA | A2ML1 | 144568 | RNAseq | 0.7633 | 0.0464 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by A2ML1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of A2ML1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | A2ML1 | 144568 | 6 | 3 | 21 | |
| GSE20123 | A2ML1 | 144568 | 6 | 3 | 21 | |
| GSE43470 | A2ML1 | 144568 | 8 | 3 | 32 | |
| GSE46452 | A2ML1 | 144568 | 10 | 1 | 48 | |
| GSE47630 | A2ML1 | 144568 | 12 | 2 | 26 | |
| GSE54993 | A2ML1 | 144568 | 1 | 10 | 59 | |
| GSE54994 | A2ML1 | 144568 | 9 | 2 | 42 | |
| GSE60625 | A2ML1 | 144568 | 0 | 1 | 10 | |
| GSE74703 | A2ML1 | 144568 | 8 | 2 | 26 | |
| GSE74704 | A2ML1 | 144568 | 4 | 2 | 14 | |
| TCGA | A2ML1 | 144568 | 40 | 6 | 50 |
Total number of gains: 104; Total number of losses: 35; Total Number of normals: 349.
Somatic mutations of A2ML1:
Generating mutation plots.
Highly correlated genes for A2ML1:
Showing top 20/1703 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| A2ML1 | CYSRT1 | 0.937893 | 6 | 0 | 6 |
| A2ML1 | SCEL | 0.894111 | 8 | 0 | 8 |
| A2ML1 | TMPRSS11B | 0.891968 | 8 | 0 | 8 |
| A2ML1 | VSIG10L | 0.886581 | 7 | 0 | 7 |
| A2ML1 | TMPRSS11E | 0.885957 | 7 | 0 | 7 |
| A2ML1 | ZNF185 | 0.883713 | 8 | 0 | 8 |
| A2ML1 | CLIC3 | 0.88255 | 6 | 0 | 6 |
| A2ML1 | CNFN | 0.880357 | 8 | 0 | 8 |
| A2ML1 | ECM1 | 0.872046 | 8 | 0 | 8 |
| A2ML1 | ENDOU | 0.871097 | 8 | 0 | 7 |
| A2ML1 | CRCT1 | 0.86607 | 8 | 0 | 8 |
| A2ML1 | GYS2 | 0.865334 | 6 | 0 | 6 |
| A2ML1 | TGM3 | 0.863546 | 8 | 0 | 8 |
| A2ML1 | CRNN | 0.86271 | 8 | 0 | 8 |
| A2ML1 | FLG | 0.862308 | 7 | 0 | 7 |
| A2ML1 | CLCA4 | 0.8607 | 8 | 0 | 8 |
| A2ML1 | NCCRP1 | 0.859576 | 4 | 0 | 4 |
| A2ML1 | KRT78 | 0.859424 | 8 | 0 | 8 |
| A2ML1 | EHD3 | 0.858481 | 7 | 0 | 7 |
| A2ML1 | IL36A | 0.856604 | 7 | 0 | 7 |
For details and further investigation, click here
