| Full name: neurolysin | Alias Symbol: KIAA1226 | ||
| Type: protein-coding gene | Cytoband: 5q12.3 | ||
| Entrez ID: 57486 | HGNC ID: HGNC:16058 | Ensembl Gene: ENSG00000123213 | OMIM ID: 611530 |
| Drug and gene relationship at DGIdb | |||
Expression of NLN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NLN | 57486 | 234762_x_at | 0.2474 | 0.7712 | |
| GSE26886 | NLN | 57486 | 234762_x_at | 0.2879 | 0.2065 | |
| GSE45670 | NLN | 57486 | 234762_x_at | 0.2383 | 0.0662 | |
| GSE53622 | NLN | 57486 | 74853 | 0.8412 | 0.0000 | |
| GSE53624 | NLN | 57486 | 74853 | 1.2916 | 0.0000 | |
| GSE63941 | NLN | 57486 | 234762_x_at | -0.1592 | 0.4925 | |
| GSE77861 | NLN | 57486 | 234762_x_at | 0.6843 | 0.1396 | |
| GSE97050 | NLN | 57486 | A_33_P3489737 | 0.7317 | 0.1417 | |
| SRP007169 | NLN | 57486 | RNAseq | 1.2417 | 0.0028 | |
| SRP008496 | NLN | 57486 | RNAseq | 0.9929 | 0.0013 | |
| SRP064894 | NLN | 57486 | RNAseq | 0.4979 | 0.0203 | |
| SRP133303 | NLN | 57486 | RNAseq | 0.6530 | 0.0004 | |
| SRP159526 | NLN | 57486 | RNAseq | 1.0381 | 0.0071 | |
| SRP193095 | NLN | 57486 | RNAseq | 0.3172 | 0.0037 | |
| SRP219564 | NLN | 57486 | RNAseq | -0.0866 | 0.8070 | |
| TCGA | NLN | 57486 | RNAseq | 0.3435 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by NLN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NLN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NLN | 57486 | 0 | 13 | 17 | |
| GSE20123 | NLN | 57486 | 0 | 13 | 17 | |
| GSE43470 | NLN | 57486 | 1 | 13 | 29 | |
| GSE46452 | NLN | 57486 | 0 | 28 | 31 | |
| GSE47630 | NLN | 57486 | 2 | 17 | 21 | |
| GSE54993 | NLN | 57486 | 8 | 1 | 61 | |
| GSE54994 | NLN | 57486 | 1 | 19 | 33 | |
| GSE60625 | NLN | 57486 | 0 | 0 | 11 | |
| GSE74703 | NLN | 57486 | 1 | 9 | 26 | |
| GSE74704 | NLN | 57486 | 0 | 6 | 14 | |
| TCGA | NLN | 57486 | 3 | 51 | 42 |
Total number of gains: 16; Total number of losses: 170; Total Number of normals: 302.
Somatic mutations of NLN:
Generating mutation plots.
Highly correlated genes for NLN:
Showing top 20/321 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NLN | SLC22A3 | 0.920411 | 5 | 0 | 5 |
| NLN | CMBL | 0.904385 | 5 | 0 | 5 |
| NLN | DDX59 | 0.867074 | 5 | 0 | 5 |
| NLN | ZNF721 | 0.853545 | 6 | 0 | 5 |
| NLN | FUT8-AS1 | 0.843831 | 4 | 0 | 4 |
| NLN | ZNF611 | 0.842339 | 5 | 0 | 5 |
| NLN | ATF7IP | 0.834426 | 5 | 0 | 5 |
| NLN | MZT2B | 0.829602 | 6 | 0 | 5 |
| NLN | ALMS1 | 0.822466 | 4 | 0 | 3 |
| NLN | GTF2H3 | 0.822391 | 6 | 0 | 6 |
| NLN | HAUS2 | 0.808002 | 6 | 0 | 6 |
| NLN | SLC35E1 | 0.803727 | 7 | 0 | 5 |
| NLN | UBXN2A | 0.798004 | 5 | 0 | 5 |
| NLN | TNRC6C-AS1 | 0.791179 | 5 | 0 | 5 |
| NLN | UACA | 0.7888 | 4 | 0 | 3 |
| NLN | CHD7 | 0.786941 | 3 | 0 | 3 |
| NLN | ZC3H7B | 0.776774 | 4 | 0 | 3 |
| NLN | PECR | 0.774352 | 6 | 0 | 6 |
| NLN | GTSE1 | 0.768826 | 6 | 0 | 6 |
| NLN | SSBP3-AS1 | 0.767019 | 5 | 0 | 5 |
For details and further investigation, click here
