| Full name: chromodomain helicase DNA binding protein 7 | Alias Symbol: KIAA1416|FLJ20357|FLJ20361 | ||
| Type: protein-coding gene | Cytoband: 8q12.2 | ||
| Entrez ID: 55636 | HGNC ID: HGNC:20626 | Ensembl Gene: ENSG00000171316 | OMIM ID: 608892 |
| Drug and gene relationship at DGIdb | |||
Expression of CHD7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHD7 | 55636 | 226123_at | 0.7428 | 0.4558 | |
| GSE20347 | CHD7 | 55636 | 218829_s_at | 0.0225 | 0.9113 | |
| GSE23400 | CHD7 | 55636 | 218829_s_at | 0.1682 | 0.1255 | |
| GSE26886 | CHD7 | 55636 | 226123_at | -0.3030 | 0.0855 | |
| GSE29001 | CHD7 | 55636 | 218829_s_at | 0.0391 | 0.9059 | |
| GSE38129 | CHD7 | 55636 | 218829_s_at | 0.1605 | 0.3685 | |
| GSE45670 | CHD7 | 55636 | 218829_s_at | 0.4195 | 0.1302 | |
| GSE53622 | CHD7 | 55636 | 6665 | -0.2827 | 0.0370 | |
| GSE53624 | CHD7 | 55636 | 6665 | -0.0142 | 0.8860 | |
| GSE63941 | CHD7 | 55636 | 218829_s_at | 3.1274 | 0.0024 | |
| GSE77861 | CHD7 | 55636 | 226123_at | 0.6684 | 0.0870 | |
| GSE97050 | CHD7 | 55636 | A_24_P289383 | 0.2643 | 0.4098 | |
| SRP007169 | CHD7 | 55636 | RNAseq | -0.2739 | 0.5124 | |
| SRP008496 | CHD7 | 55636 | RNAseq | -0.1286 | 0.7323 | |
| SRP064894 | CHD7 | 55636 | RNAseq | 0.5185 | 0.0446 | |
| SRP133303 | CHD7 | 55636 | RNAseq | 0.1504 | 0.3436 | |
| SRP159526 | CHD7 | 55636 | RNAseq | -0.1303 | 0.6860 | |
| SRP193095 | CHD7 | 55636 | RNAseq | 0.0705 | 0.6581 | |
| SRP219564 | CHD7 | 55636 | RNAseq | -0.0836 | 0.8817 | |
| TCGA | CHD7 | 55636 | RNAseq | 0.0201 | 0.7756 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CHD7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHD7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHD7 | 55636 | 13 | 1 | 16 | |
| GSE20123 | CHD7 | 55636 | 13 | 1 | 16 | |
| GSE43470 | CHD7 | 55636 | 14 | 3 | 26 | |
| GSE46452 | CHD7 | 55636 | 20 | 2 | 37 | |
| GSE47630 | CHD7 | 55636 | 23 | 1 | 16 | |
| GSE54993 | CHD7 | 55636 | 1 | 18 | 51 | |
| GSE54994 | CHD7 | 55636 | 30 | 0 | 23 | |
| GSE60625 | CHD7 | 55636 | 0 | 4 | 7 | |
| GSE74703 | CHD7 | 55636 | 12 | 2 | 22 | |
| GSE74704 | CHD7 | 55636 | 9 | 0 | 11 | |
| TCGA | CHD7 | 55636 | 46 | 6 | 44 |
Total number of gains: 181; Total number of losses: 38; Total Number of normals: 269.
Somatic mutations of CHD7:
Generating mutation plots.
Highly correlated genes for CHD7:
Showing top 20/382 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHD7 | C9orf64 | 0.841011 | 3 | 0 | 3 |
| CHD7 | SAMD1 | 0.828808 | 3 | 0 | 3 |
| CHD7 | ATF7IP | 0.818138 | 3 | 0 | 3 |
| CHD7 | LYAR | 0.803588 | 3 | 0 | 3 |
| CHD7 | PIAS3 | 0.791096 | 3 | 0 | 3 |
| CHD7 | PRR14L | 0.791052 | 3 | 0 | 3 |
| CHD7 | ESCO2 | 0.789028 | 3 | 0 | 3 |
| CHD7 | NLN | 0.786941 | 3 | 0 | 3 |
| CHD7 | TMEM241 | 0.782426 | 3 | 0 | 3 |
| CHD7 | UTP23 | 0.781553 | 3 | 0 | 3 |
| CHD7 | ARHGAP39 | 0.773047 | 3 | 0 | 3 |
| CHD7 | ARHGEF16 | 0.765009 | 3 | 0 | 3 |
| CHD7 | PDCD5 | 0.751606 | 3 | 0 | 3 |
| CHD7 | FCF1 | 0.744772 | 3 | 0 | 3 |
| CHD7 | PLEKHH1 | 0.740526 | 4 | 0 | 4 |
| CHD7 | SFSWAP | 0.717222 | 4 | 0 | 4 |
| CHD7 | DDX55 | 0.714741 | 4 | 0 | 3 |
| CHD7 | GTF2H3 | 0.713571 | 4 | 0 | 3 |
| CHD7 | DHX35 | 0.708817 | 3 | 0 | 3 |
| CHD7 | STRBP | 0.708327 | 3 | 0 | 3 |
For details and further investigation, click here
