| Full name: NLR family pyrin domain containing 8 | Alias Symbol: NOD16|PAN4|CLR19.2 | ||
| Type: protein-coding gene | Cytoband: 19q13.43 | ||
| Entrez ID: 126205 | HGNC ID: HGNC:22940 | Ensembl Gene: ENSG00000179709 | OMIM ID: 609659 |
| Drug and gene relationship at DGIdb | |||
Expression of NLRP8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NLRP8 | 126205 | 1553526_at | -0.2240 | 0.3968 | |
| GSE26886 | NLRP8 | 126205 | 1553526_at | -0.4421 | 0.0008 | |
| GSE45670 | NLRP8 | 126205 | 1553526_at | -0.0598 | 0.6858 | |
| GSE53622 | NLRP8 | 126205 | 35880 | 0.2776 | 0.0917 | |
| GSE53624 | NLRP8 | 126205 | 35880 | 0.6063 | 0.0025 | |
| GSE63941 | NLRP8 | 126205 | 1553526_at | 0.2127 | 0.0602 | |
| GSE77861 | NLRP8 | 126205 | 1553526_at | -0.3900 | 0.0086 | |
| SRP133303 | NLRP8 | 126205 | RNAseq | 0.2322 | 0.4527 | |
| TCGA | NLRP8 | 126205 | RNAseq | 1.0646 | 0.6262 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NLRP8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NLRP8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NLRP8 | 126205 | 3 | 4 | 23 | |
| GSE20123 | NLRP8 | 126205 | 3 | 3 | 24 | |
| GSE43470 | NLRP8 | 126205 | 3 | 9 | 31 | |
| GSE46452 | NLRP8 | 126205 | 45 | 1 | 13 | |
| GSE47630 | NLRP8 | 126205 | 8 | 6 | 26 | |
| GSE54993 | NLRP8 | 126205 | 17 | 4 | 49 | |
| GSE54994 | NLRP8 | 126205 | 4 | 13 | 36 | |
| GSE60625 | NLRP8 | 126205 | 9 | 0 | 2 | |
| GSE74703 | NLRP8 | 126205 | 3 | 6 | 27 | |
| GSE74704 | NLRP8 | 126205 | 3 | 1 | 16 | |
| TCGA | NLRP8 | 126205 | 19 | 15 | 62 |
Total number of gains: 117; Total number of losses: 62; Total Number of normals: 309.
Somatic mutations of NLRP8:
Generating mutation plots.
Highly correlated genes for NLRP8:
Showing top 20/340 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NLRP8 | C10orf90 | 0.709936 | 3 | 0 | 3 |
| NLRP8 | LRRC43 | 0.704929 | 3 | 0 | 3 |
| NLRP8 | ST3GAL3 | 0.703998 | 5 | 0 | 5 |
| NLRP8 | KIAA0408 | 0.698496 | 3 | 0 | 3 |
| NLRP8 | INSL3 | 0.698151 | 5 | 0 | 5 |
| NLRP8 | ODF4 | 0.69788 | 4 | 0 | 4 |
| NLRP8 | MRO | 0.694652 | 3 | 0 | 3 |
| NLRP8 | SMR3B | 0.685645 | 4 | 0 | 4 |
| NLRP8 | C2orf16 | 0.677232 | 5 | 0 | 5 |
| NLRP8 | PRB4 | 0.67486 | 3 | 0 | 3 |
| NLRP8 | OMP | 0.674611 | 3 | 0 | 3 |
| NLRP8 | PRRG4 | 0.667394 | 3 | 0 | 3 |
| NLRP8 | RAB4B | 0.667312 | 5 | 0 | 4 |
| NLRP8 | MPV17L | 0.666969 | 3 | 0 | 3 |
| NLRP8 | ABHD14B | 0.663217 | 3 | 0 | 3 |
| NLRP8 | RAB5B | 0.661605 | 3 | 0 | 3 |
| NLRP8 | PRSS58 | 0.661233 | 4 | 0 | 3 |
| NLRP8 | SLC34A3 | 0.659834 | 4 | 0 | 4 |
| NLRP8 | PRSS33 | 0.65719 | 5 | 0 | 4 |
| NLRP8 | RBP5 | 0.655471 | 4 | 0 | 3 |
For details and further investigation, click here
