| Full name: RAB5B, member RAS oncogene family | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q13 | ||
| Entrez ID: 5869 | HGNC ID: HGNC:9784 | Ensembl Gene: | OMIM ID: 179514 |
| Drug and gene relationship at DGIdb | |||
RAB5B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa05152 | Tuberculosis |
Expression of RAB5B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAB5B | 5869 | 201276_at | -0.4335 | 0.3169 | |
| GSE20347 | RAB5B | 5869 | 201276_at | -1.0482 | 0.0000 | |
| GSE23400 | RAB5B | 5869 | 201276_at | -0.7961 | 0.0000 | |
| GSE26886 | RAB5B | 5869 | 201276_at | -1.4152 | 0.0000 | |
| GSE29001 | RAB5B | 5869 | 201276_at | -0.9573 | 0.0026 | |
| GSE38129 | RAB5B | 5869 | 201276_at | -0.8296 | 0.0000 | |
| GSE45670 | RAB5B | 5869 | 201276_at | -0.4700 | 0.0101 | |
| GSE53622 | RAB5B | 5869 | 60325 | -1.1712 | 0.0000 | |
| GSE53624 | RAB5B | 5869 | 60325 | -1.2137 | 0.0000 | |
| GSE63941 | RAB5B | 5869 | 201276_at | 0.0262 | 0.9620 | |
| GSE77861 | RAB5B | 5869 | 201276_at | -0.8338 | 0.0005 | |
| GSE97050 | RAB5B | 5869 | A_23_P410998 | -0.9101 | 0.0620 | |
| SRP007169 | RAB5B | 5869 | RNAseq | -2.3739 | 0.0000 | |
| SRP008496 | RAB5B | 5869 | RNAseq | -2.2046 | 0.0000 | |
| SRP064894 | RAB5B | 5869 | RNAseq | -1.1920 | 0.0000 | |
| SRP133303 | RAB5B | 5869 | RNAseq | -0.6747 | 0.0000 | |
| SRP159526 | RAB5B | 5869 | RNAseq | -1.0863 | 0.0001 | |
| SRP193095 | RAB5B | 5869 | RNAseq | -1.1574 | 0.0000 | |
| SRP219564 | RAB5B | 5869 | RNAseq | -0.9669 | 0.0000 | |
| TCGA | RAB5B | 5869 | RNAseq | -0.1530 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by RAB5B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAB5B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAB5B | 5869 | 6 | 2 | 22 | |
| GSE20123 | RAB5B | 5869 | 6 | 1 | 23 | |
| GSE43470 | RAB5B | 5869 | 4 | 0 | 39 | |
| GSE46452 | RAB5B | 5869 | 8 | 1 | 50 | |
| GSE47630 | RAB5B | 5869 | 10 | 2 | 28 | |
| GSE54993 | RAB5B | 5869 | 0 | 5 | 65 | |
| GSE54994 | RAB5B | 5869 | 4 | 1 | 48 | |
| GSE60625 | RAB5B | 5869 | 0 | 0 | 11 | |
| GSE74703 | RAB5B | 5869 | 4 | 0 | 32 | |
| GSE74704 | RAB5B | 5869 | 4 | 1 | 15 | |
| TCGA | RAB5B | 5869 | 15 | 10 | 71 |
Total number of gains: 61; Total number of losses: 23; Total Number of normals: 404.
Somatic mutations of RAB5B:
Generating mutation plots.
Highly correlated genes for RAB5B:
Showing top 20/1999 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAB5B | ANKRD13A | 0.816682 | 6 | 0 | 6 |
| RAB5B | VSIG10L | 0.809906 | 5 | 0 | 5 |
| RAB5B | ACOX3 | 0.809373 | 10 | 0 | 10 |
| RAB5B | CPPED1 | 0.809245 | 9 | 0 | 9 |
| RAB5B | RMND5B | 0.807772 | 11 | 0 | 11 |
| RAB5B | ARHGEF10L | 0.805541 | 12 | 0 | 11 |
| RAB5B | SNORA68 | 0.804299 | 4 | 0 | 4 |
| RAB5B | CPEB3 | 0.802873 | 10 | 0 | 10 |
| RAB5B | SASH1 | 0.800667 | 11 | 0 | 11 |
| RAB5B | RNF10 | 0.797603 | 11 | 0 | 11 |
| RAB5B | MPP7 | 0.794865 | 7 | 0 | 6 |
| RAB5B | SCNN1B | 0.793291 | 10 | 0 | 10 |
| RAB5B | CAPN14 | 0.792776 | 5 | 0 | 5 |
| RAB5B | PDLIM2 | 0.790004 | 8 | 0 | 8 |
| RAB5B | C5orf66-AS1 | 0.78837 | 6 | 0 | 6 |
| RAB5B | SPAG17 | 0.784529 | 3 | 0 | 3 |
| RAB5B | CRCT1 | 0.783337 | 9 | 0 | 9 |
| RAB5B | SLC16A6 | 0.781735 | 10 | 0 | 10 |
| RAB5B | KAT2B | 0.780778 | 11 | 0 | 9 |
| RAB5B | ABLIM1 | 0.780579 | 11 | 0 | 11 |
For details and further investigation, click here
