| Full name: insulin like 3 | Alias Symbol: RLF|MGC119818|MGC119819 | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 3640 | HGNC ID: HGNC:6086 | Ensembl Gene: ENSG00000248099 | OMIM ID: 146738 |
| Drug and gene relationship at DGIdb | |||
Expression of INSL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | INSL3 | 3640 | 1553594_a_at | -0.1546 | 0.4574 | |
| GSE20347 | INSL3 | 3640 | 214572_s_at | -0.1699 | 0.0369 | |
| GSE23400 | INSL3 | 3640 | 214572_s_at | -0.0656 | 0.0496 | |
| GSE26886 | INSL3 | 3640 | 1553594_a_at | -0.3766 | 0.0207 | |
| GSE29001 | INSL3 | 3640 | 214572_s_at | -0.2854 | 0.0605 | |
| GSE38129 | INSL3 | 3640 | 214572_s_at | -0.1784 | 0.0255 | |
| GSE45670 | INSL3 | 3640 | 1553594_a_at | -0.1080 | 0.3415 | |
| GSE53622 | INSL3 | 3640 | 35912 | -0.1183 | 0.1293 | |
| GSE53624 | INSL3 | 3640 | 35912 | -0.3722 | 0.0000 | |
| GSE63941 | INSL3 | 3640 | 1553594_a_at | 0.4311 | 0.0208 | |
| GSE77861 | INSL3 | 3640 | 1553594_a_at | -0.3295 | 0.0224 | |
| GSE97050 | INSL3 | 3640 | A_33_P3334828 | 0.1440 | 0.4958 | |
| SRP133303 | INSL3 | 3640 | RNAseq | -0.3679 | 0.1561 | |
| SRP219564 | INSL3 | 3640 | RNAseq | 0.2966 | 0.6193 | |
| TCGA | INSL3 | 3640 | RNAseq | -1.3542 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by INSL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of INSL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | INSL3 | 3640 | 4 | 4 | 22 | |
| GSE20123 | INSL3 | 3640 | 3 | 2 | 25 | |
| GSE43470 | INSL3 | 3640 | 2 | 6 | 35 | |
| GSE46452 | INSL3 | 3640 | 47 | 1 | 11 | |
| GSE47630 | INSL3 | 3640 | 4 | 8 | 28 | |
| GSE54993 | INSL3 | 3640 | 15 | 4 | 51 | |
| GSE54994 | INSL3 | 3640 | 6 | 14 | 33 | |
| GSE60625 | INSL3 | 3640 | 9 | 0 | 2 | |
| GSE74703 | INSL3 | 3640 | 2 | 4 | 30 | |
| GSE74704 | INSL3 | 3640 | 0 | 2 | 18 | |
| TCGA | INSL3 | 3640 | 17 | 9 | 70 |
Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.
Somatic mutations of INSL3:
Generating mutation plots.
Highly correlated genes for INSL3:
Showing top 20/1178 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| INSL3 | OTOG | 0.804133 | 3 | 0 | 3 |
| INSL3 | YY2 | 0.789578 | 3 | 0 | 3 |
| INSL3 | PRSS38 | 0.77636 | 3 | 0 | 3 |
| INSL3 | C10orf90 | 0.774962 | 4 | 0 | 4 |
| INSL3 | FTHL17 | 0.765022 | 3 | 0 | 3 |
| INSL3 | RNF180 | 0.762522 | 5 | 0 | 5 |
| INSL3 | SLC22A12 | 0.755294 | 4 | 0 | 4 |
| INSL3 | OR10AD1 | 0.746084 | 3 | 0 | 3 |
| INSL3 | OR2B11 | 0.741424 | 3 | 0 | 3 |
| INSL3 | STRC | 0.738255 | 3 | 0 | 3 |
| INSL3 | KRTAP10-12 | 0.737884 | 3 | 0 | 3 |
| INSL3 | CIB3 | 0.735603 | 4 | 0 | 4 |
| INSL3 | SP7 | 0.730063 | 3 | 0 | 3 |
| INSL3 | TTC21A | 0.728159 | 3 | 0 | 3 |
| INSL3 | LINC00163 | 0.720967 | 3 | 0 | 3 |
| INSL3 | GDF7 | 0.72032 | 3 | 0 | 3 |
| INSL3 | DEFB121 | 0.719109 | 5 | 0 | 5 |
| INSL3 | ACTA2-AS1 | 0.715983 | 3 | 0 | 3 |
| INSL3 | RNF157 | 0.713156 | 3 | 0 | 3 |
| INSL3 | MUC17 | 0.709667 | 3 | 0 | 3 |
For details and further investigation, click here
