| Full name: serine protease 58 | Alias Symbol: TRYX3 | ||
| Type: protein-coding gene | Cytoband: 7q34 | ||
| Entrez ID: 136541 | HGNC ID: HGNC:39125 | Ensembl Gene: ENSG00000258223 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of PRSS58:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRSS58 | 136541 | 237513_at | -0.3302 | 0.1770 | |
| GSE26886 | PRSS58 | 136541 | 237513_at | -0.5190 | 0.0007 | |
| GSE45670 | PRSS58 | 136541 | 237513_at | -0.0052 | 0.9653 | |
| GSE53622 | PRSS58 | 136541 | 126677 | 0.1708 | 0.4404 | |
| GSE53624 | PRSS58 | 136541 | 126677 | 0.4748 | 0.0000 | |
| GSE63941 | PRSS58 | 136541 | 237513_at | -0.0048 | 0.9842 | |
| GSE77861 | PRSS58 | 136541 | 237513_at | -0.0196 | 0.8733 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PRSS58 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of PRSS58:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRSS58 | 136541 | 3 | 2 | 25 | |
| GSE20123 | PRSS58 | 136541 | 3 | 2 | 25 | |
| GSE43470 | PRSS58 | 136541 | 2 | 4 | 37 | |
| GSE46452 | PRSS58 | 136541 | 7 | 2 | 50 | |
| GSE47630 | PRSS58 | 136541 | 6 | 7 | 27 | |
| GSE54993 | PRSS58 | 136541 | 3 | 4 | 63 | |
| GSE54994 | PRSS58 | 136541 | 5 | 8 | 40 | |
| GSE60625 | PRSS58 | 136541 | 0 | 0 | 11 | |
| GSE74703 | PRSS58 | 136541 | 2 | 4 | 30 | |
| GSE74704 | PRSS58 | 136541 | 1 | 2 | 17 | |
| TCGA | PRSS58 | 136541 | 29 | 23 | 44 |
Total number of gains: 61; Total number of losses: 58; Total Number of normals: 369.
Somatic mutations of PRSS58:
Generating mutation plots.
Highly correlated genes for PRSS58:
Showing top 20/117 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRSS58 | RAB4B | 0.71375 | 3 | 0 | 3 |
| PRSS58 | CCDC13 | 0.710185 | 3 | 0 | 3 |
| PRSS58 | EDDM3A | 0.704248 | 3 | 0 | 3 |
| PRSS58 | FSD2 | 0.70387 | 3 | 0 | 3 |
| PRSS58 | TTTY11 | 0.699379 | 4 | 0 | 4 |
| PRSS58 | ABO | 0.677935 | 3 | 0 | 3 |
| PRSS58 | E2F4 | 0.661393 | 3 | 0 | 3 |
| PRSS58 | NLRP8 | 0.661233 | 4 | 0 | 3 |
| PRSS58 | KRTAP5-8 | 0.657091 | 3 | 0 | 3 |
| PRSS58 | CNBD2 | 0.654987 | 3 | 0 | 3 |
| PRSS58 | ST3GAL3 | 0.649133 | 4 | 0 | 4 |
| PRSS58 | WASF2 | 0.647266 | 3 | 0 | 3 |
| PRSS58 | LINGO3 | 0.646516 | 4 | 0 | 4 |
| PRSS58 | S100G | 0.639656 | 4 | 0 | 3 |
| PRSS58 | EPB42 | 0.635953 | 4 | 0 | 3 |
| PRSS58 | SLC34A3 | 0.627899 | 4 | 0 | 3 |
| PRSS58 | LINC00692 | 0.626174 | 3 | 0 | 3 |
| PRSS58 | CNR2 | 0.620313 | 4 | 0 | 4 |
| PRSS58 | HTR1E | 0.619713 | 3 | 0 | 3 |
| PRSS58 | TMEM95 | 0.619389 | 3 | 0 | 3 |
For details and further investigation, click here
