| Full name: NME/NM23 nucleoside diphosphate kinase 6 | Alias Symbol: NM23-H6|IPIA-ALPHA | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 10201 | HGNC ID: HGNC:20567 | Ensembl Gene: ENSG00000172113 | OMIM ID: 608294 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NME6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NME6 | 10201 | 205851_at | -0.3439 | 0.4636 | |
| GSE20347 | NME6 | 10201 | 205851_at | -0.5565 | 0.0024 | |
| GSE23400 | NME6 | 10201 | 205851_at | -0.1367 | 0.0033 | |
| GSE26886 | NME6 | 10201 | 205851_at | -0.5573 | 0.0033 | |
| GSE29001 | NME6 | 10201 | 205851_at | -0.4713 | 0.0278 | |
| GSE38129 | NME6 | 10201 | 205851_at | -0.5266 | 0.0001 | |
| GSE45670 | NME6 | 10201 | 205851_at | -0.0468 | 0.6377 | |
| GSE53622 | NME6 | 10201 | 122393 | -0.3545 | 0.0000 | |
| GSE53624 | NME6 | 10201 | 122393 | -0.4466 | 0.0000 | |
| GSE63941 | NME6 | 10201 | 205851_at | 0.2213 | 0.5090 | |
| GSE77861 | NME6 | 10201 | 205851_at | -0.4121 | 0.0493 | |
| GSE97050 | NME6 | 10201 | A_23_P313961 | 0.0213 | 0.9436 | |
| SRP007169 | NME6 | 10201 | RNAseq | -0.8521 | 0.0092 | |
| SRP008496 | NME6 | 10201 | RNAseq | -0.9891 | 0.0000 | |
| SRP064894 | NME6 | 10201 | RNAseq | -0.2018 | 0.0546 | |
| SRP133303 | NME6 | 10201 | RNAseq | -0.3256 | 0.0041 | |
| SRP159526 | NME6 | 10201 | RNAseq | -0.6120 | 0.0117 | |
| SRP193095 | NME6 | 10201 | RNAseq | -0.4370 | 0.0000 | |
| SRP219564 | NME6 | 10201 | RNAseq | -0.2968 | 0.3046 | |
| TCGA | NME6 | 10201 | RNAseq | -0.1579 | 0.0134 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NME6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NME6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NME6 | 10201 | 0 | 18 | 12 | |
| GSE20123 | NME6 | 10201 | 0 | 19 | 11 | |
| GSE43470 | NME6 | 10201 | 0 | 19 | 24 | |
| GSE46452 | NME6 | 10201 | 2 | 17 | 40 | |
| GSE47630 | NME6 | 10201 | 1 | 24 | 15 | |
| GSE54993 | NME6 | 10201 | 6 | 2 | 62 | |
| GSE54994 | NME6 | 10201 | 0 | 36 | 17 | |
| GSE60625 | NME6 | 10201 | 5 | 0 | 6 | |
| GSE74703 | NME6 | 10201 | 0 | 15 | 21 | |
| GSE74704 | NME6 | 10201 | 0 | 12 | 8 | |
| TCGA | NME6 | 10201 | 0 | 77 | 19 |
Total number of gains: 14; Total number of losses: 239; Total Number of normals: 235.
Somatic mutations of NME6:
Generating mutation plots.
Highly correlated genes for NME6:
Showing top 20/995 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NME6 | TMEM50B | 0.800976 | 3 | 0 | 3 |
| NME6 | GPR108 | 0.787743 | 3 | 0 | 3 |
| NME6 | ZNF570 | 0.741531 | 3 | 0 | 3 |
| NME6 | ALKBH7 | 0.740527 | 3 | 0 | 3 |
| NME6 | MRFAP1L1 | 0.7294 | 3 | 0 | 3 |
| NME6 | UBL5 | 0.720929 | 4 | 0 | 4 |
| NME6 | ATRIP | 0.715282 | 3 | 0 | 3 |
| NME6 | UBE2E2 | 0.712468 | 4 | 0 | 4 |
| NME6 | RPUSD3 | 0.709307 | 4 | 0 | 4 |
| NME6 | SUSD1 | 0.707024 | 3 | 0 | 3 |
| NME6 | SLU7 | 0.703192 | 3 | 0 | 3 |
| NME6 | STOML2 | 0.699983 | 3 | 0 | 3 |
| NME6 | CCDC85C | 0.699633 | 3 | 0 | 3 |
| NME6 | ZFAND1 | 0.699573 | 3 | 0 | 3 |
| NME6 | PLEKHJ1 | 0.697339 | 3 | 0 | 3 |
| NME6 | GMPPB | 0.694857 | 4 | 0 | 3 |
| NME6 | DCAF10 | 0.694341 | 7 | 0 | 6 |
| NME6 | MCFD2 | 0.693469 | 4 | 0 | 3 |
| NME6 | LCMT1 | 0.692542 | 3 | 0 | 3 |
| NME6 | TMEM219 | 0.690968 | 3 | 0 | 3 |
For details and further investigation, click here
