| Full name: GDP-mannose pyrophosphorylase B | Alias Symbol: KIAA1851 | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 29925 | HGNC ID: HGNC:22932 | Ensembl Gene: ENSG00000173540 | OMIM ID: 615320 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GMPPB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | GMPPB | 29925 | 40723 | -0.4490 | 0.0000 | |
| GSE53624 | GMPPB | 29925 | 8204 | -1.0476 | 0.0000 | |
| GSE97050 | GMPPB | 29925 | A_23_P92202 | 0.0199 | 0.9378 | |
| SRP007169 | GMPPB | 29925 | RNAseq | -1.7924 | 0.0000 | |
| SRP008496 | GMPPB | 29925 | RNAseq | -1.7665 | 0.0000 | |
| SRP064894 | GMPPB | 29925 | RNAseq | -0.6165 | 0.0001 | |
| SRP133303 | GMPPB | 29925 | RNAseq | -0.5353 | 0.0038 | |
| SRP159526 | GMPPB | 29925 | RNAseq | -0.6703 | 0.0012 | |
| SRP193095 | GMPPB | 29925 | RNAseq | -0.7502 | 0.0000 | |
| SRP219564 | GMPPB | 29925 | RNAseq | -0.7394 | 0.0052 | |
| TCGA | GMPPB | 29925 | RNAseq | -0.3983 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by GMPPB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GMPPB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GMPPB | 29925 | 0 | 18 | 12 | |
| GSE20123 | GMPPB | 29925 | 0 | 19 | 11 | |
| GSE43470 | GMPPB | 29925 | 0 | 18 | 25 | |
| GSE46452 | GMPPB | 29925 | 2 | 16 | 41 | |
| GSE47630 | GMPPB | 29925 | 1 | 24 | 15 | |
| GSE54993 | GMPPB | 29925 | 6 | 2 | 62 | |
| GSE54994 | GMPPB | 29925 | 0 | 36 | 17 | |
| GSE60625 | GMPPB | 29925 | 5 | 0 | 6 | |
| GSE74703 | GMPPB | 29925 | 0 | 14 | 22 | |
| GSE74704 | GMPPB | 29925 | 0 | 12 | 8 | |
| TCGA | GMPPB | 29925 | 0 | 77 | 19 |
Total number of gains: 14; Total number of losses: 236; Total Number of normals: 238.
Somatic mutations of GMPPB:
Generating mutation plots.
Highly correlated genes for GMPPB:
Showing top 20/266 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GMPPB | KLHL18 | 0.818609 | 3 | 0 | 3 |
| GMPPB | EIF2B4 | 0.754984 | 3 | 0 | 3 |
| GMPPB | RAB14 | 0.748539 | 3 | 0 | 3 |
| GMPPB | DCTN3 | 0.743527 | 3 | 0 | 3 |
| GMPPB | KCTD6 | 0.742577 | 3 | 0 | 3 |
| GMPPB | PRADC1 | 0.741998 | 3 | 0 | 3 |
| GMPPB | RHOA | 0.741712 | 3 | 0 | 3 |
| GMPPB | PRMT2 | 0.736968 | 3 | 0 | 3 |
| GMPPB | FLII | 0.735018 | 3 | 0 | 3 |
| GMPPB | RPUSD3 | 0.730473 | 3 | 0 | 3 |
| GMPPB | KIAA0556 | 0.724378 | 3 | 0 | 3 |
| GMPPB | ALAS1 | 0.719321 | 3 | 0 | 3 |
| GMPPB | FIS1 | 0.719128 | 3 | 0 | 3 |
| GMPPB | ATP6V1E1 | 0.716159 | 3 | 0 | 3 |
| GMPPB | GUK1 | 0.71478 | 3 | 0 | 3 |
| GMPPB | NOSIP | 0.714128 | 3 | 0 | 3 |
| GMPPB | IK | 0.713703 | 3 | 0 | 3 |
| GMPPB | DALRD3 | 0.712816 | 3 | 0 | 3 |
| GMPPB | TMEM19 | 0.712573 | 3 | 0 | 3 |
| GMPPB | ALKBH7 | 0.711696 | 3 | 0 | 3 |
For details and further investigation, click here
