| Full name: multiple coagulation factor deficiency 2 | Alias Symbol: F5F8D|LMAN1IP|SDNSF | ||
| Type: protein-coding gene | Cytoband: 2p21 | ||
| Entrez ID: 90411 | HGNC ID: HGNC:18451 | Ensembl Gene: ENSG00000180398 | OMIM ID: 607788 |
| Drug and gene relationship at DGIdb | |||
Expression of MCFD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MCFD2 | 90411 | 212245_at | -0.2155 | 0.6787 | |
| GSE20347 | MCFD2 | 90411 | 212245_at | -0.4109 | 0.0104 | |
| GSE23400 | MCFD2 | 90411 | 212245_at | -0.0785 | 0.4143 | |
| GSE26886 | MCFD2 | 90411 | 212245_at | -0.4365 | 0.0191 | |
| GSE29001 | MCFD2 | 90411 | 212245_at | -0.2841 | 0.3085 | |
| GSE38129 | MCFD2 | 90411 | 212245_at | -0.2687 | 0.0248 | |
| GSE45670 | MCFD2 | 90411 | 212245_at | -0.1354 | 0.4035 | |
| GSE53622 | MCFD2 | 90411 | 63483 | -0.3276 | 0.0000 | |
| GSE53624 | MCFD2 | 90411 | 63483 | -0.5156 | 0.0000 | |
| GSE63941 | MCFD2 | 90411 | 212245_at | -1.3262 | 0.0041 | |
| GSE77861 | MCFD2 | 90411 | 212245_at | -0.1798 | 0.5209 | |
| GSE97050 | MCFD2 | 90411 | A_23_P120270 | -0.0960 | 0.7153 | |
| SRP007169 | MCFD2 | 90411 | RNAseq | 0.0123 | 0.9730 | |
| SRP008496 | MCFD2 | 90411 | RNAseq | 0.1090 | 0.6162 | |
| SRP064894 | MCFD2 | 90411 | RNAseq | -0.3401 | 0.0361 | |
| SRP133303 | MCFD2 | 90411 | RNAseq | -0.1400 | 0.1318 | |
| SRP159526 | MCFD2 | 90411 | RNAseq | -0.1670 | 0.4043 | |
| SRP193095 | MCFD2 | 90411 | RNAseq | 0.0423 | 0.5828 | |
| SRP219564 | MCFD2 | 90411 | RNAseq | -0.2505 | 0.3529 | |
| TCGA | MCFD2 | 90411 | RNAseq | -0.1492 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MCFD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MCFD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MCFD2 | 90411 | 10 | 1 | 19 | |
| GSE20123 | MCFD2 | 90411 | 8 | 1 | 21 | |
| GSE43470 | MCFD2 | 90411 | 5 | 0 | 38 | |
| GSE46452 | MCFD2 | 90411 | 1 | 4 | 54 | |
| GSE47630 | MCFD2 | 90411 | 7 | 0 | 33 | |
| GSE54993 | MCFD2 | 90411 | 0 | 5 | 65 | |
| GSE54994 | MCFD2 | 90411 | 10 | 0 | 43 | |
| GSE60625 | MCFD2 | 90411 | 0 | 3 | 8 | |
| GSE74703 | MCFD2 | 90411 | 5 | 0 | 31 | |
| GSE74704 | MCFD2 | 90411 | 9 | 1 | 10 | |
| TCGA | MCFD2 | 90411 | 35 | 3 | 58 |
Total number of gains: 90; Total number of losses: 18; Total Number of normals: 380.
Somatic mutations of MCFD2:
Generating mutation plots.
Highly correlated genes for MCFD2:
Showing top 20/652 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MCFD2 | TSNAX | 0.799571 | 3 | 0 | 3 |
| MCFD2 | BTBD7 | 0.797632 | 3 | 0 | 3 |
| MCFD2 | FNBP1 | 0.796087 | 3 | 0 | 3 |
| MCFD2 | UBE2E2 | 0.763337 | 3 | 0 | 3 |
| MCFD2 | SCAMP1 | 0.760416 | 3 | 0 | 3 |
| MCFD2 | SLC30A5 | 0.740824 | 3 | 0 | 3 |
| MCFD2 | SYNE1 | 0.738836 | 3 | 0 | 3 |
| MCFD2 | IMPACT | 0.737566 | 3 | 0 | 3 |
| MCFD2 | CNST | 0.734796 | 3 | 0 | 3 |
| MCFD2 | BBS7 | 0.728105 | 3 | 0 | 3 |
| MCFD2 | DAD1 | 0.720366 | 3 | 0 | 3 |
| MCFD2 | BMPR2 | 0.716417 | 3 | 0 | 3 |
| MCFD2 | ZNF596 | 0.71543 | 3 | 0 | 3 |
| MCFD2 | MLX | 0.712682 | 3 | 0 | 3 |
| MCFD2 | UBE2V2 | 0.705607 | 3 | 0 | 3 |
| MCFD2 | ARL4C | 0.70401 | 3 | 0 | 3 |
| MCFD2 | PTPRG | 0.700591 | 3 | 0 | 3 |
| MCFD2 | CRIPT | 0.700548 | 4 | 0 | 3 |
| MCFD2 | PFKFB2 | 0.694168 | 3 | 0 | 3 |
| MCFD2 | NME6 | 0.693469 | 4 | 0 | 3 |
For details and further investigation, click here
