| Full name: transmembrane protein 50B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 21q22.11 | ||
| Entrez ID: 757 | HGNC ID: HGNC:1280 | Ensembl Gene: ENSG00000142188 | OMIM ID: 617894 |
| Drug and gene relationship at DGIdb | |||
Expression of TMEM50B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM50B | 757 | 225182_at | -0.4247 | 0.5271 | |
| GSE20347 | TMEM50B | 757 | 219600_s_at | -0.3275 | 0.0801 | |
| GSE23400 | TMEM50B | 757 | 219600_s_at | -0.2296 | 0.0113 | |
| GSE26886 | TMEM50B | 757 | 225182_at | -0.8672 | 0.0033 | |
| GSE29001 | TMEM50B | 757 | 219600_s_at | -0.2266 | 0.4633 | |
| GSE38129 | TMEM50B | 757 | 219600_s_at | -0.2504 | 0.1105 | |
| GSE45670 | TMEM50B | 757 | 225182_at | -0.6348 | 0.0005 | |
| GSE53622 | TMEM50B | 757 | 32114 | -0.3782 | 0.0000 | |
| GSE53624 | TMEM50B | 757 | 59725 | -0.8016 | 0.0000 | |
| GSE63941 | TMEM50B | 757 | 219600_s_at | -0.5606 | 0.2348 | |
| GSE77861 | TMEM50B | 757 | 225182_at | -0.8872 | 0.0082 | |
| GSE97050 | TMEM50B | 757 | A_24_P305623 | -0.3406 | 0.2660 | |
| SRP007169 | TMEM50B | 757 | RNAseq | -1.4409 | 0.0000 | |
| SRP008496 | TMEM50B | 757 | RNAseq | -0.8429 | 0.0006 | |
| SRP064894 | TMEM50B | 757 | RNAseq | -0.3945 | 0.0051 | |
| SRP133303 | TMEM50B | 757 | RNAseq | -0.3645 | 0.0897 | |
| SRP159526 | TMEM50B | 757 | RNAseq | -0.2824 | 0.4694 | |
| SRP193095 | TMEM50B | 757 | RNAseq | -0.8674 | 0.0000 | |
| SRP219564 | TMEM50B | 757 | RNAseq | -0.6659 | 0.0976 | |
| TCGA | TMEM50B | 757 | RNAseq | -0.3387 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TMEM50B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM50B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM50B | 757 | 2 | 8 | 20 | |
| GSE20123 | TMEM50B | 757 | 2 | 9 | 19 | |
| GSE43470 | TMEM50B | 757 | 3 | 9 | 31 | |
| GSE46452 | TMEM50B | 757 | 1 | 21 | 37 | |
| GSE47630 | TMEM50B | 757 | 6 | 17 | 17 | |
| GSE54993 | TMEM50B | 757 | 9 | 1 | 60 | |
| GSE54994 | TMEM50B | 757 | 1 | 9 | 43 | |
| GSE60625 | TMEM50B | 757 | 0 | 0 | 11 | |
| GSE74703 | TMEM50B | 757 | 3 | 6 | 27 | |
| GSE74704 | TMEM50B | 757 | 1 | 4 | 15 | |
| TCGA | TMEM50B | 757 | 9 | 35 | 52 |
Total number of gains: 37; Total number of losses: 119; Total Number of normals: 332.
Somatic mutations of TMEM50B:
Generating mutation plots.
Highly correlated genes for TMEM50B:
Showing top 20/1069 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM50B | NME6 | 0.800976 | 3 | 0 | 3 |
| TMEM50B | C2CD2 | 0.788693 | 3 | 0 | 3 |
| TMEM50B | RPS9 | 0.787029 | 3 | 0 | 3 |
| TMEM50B | ZFAND5 | 0.785419 | 3 | 0 | 3 |
| TMEM50B | COG6 | 0.770434 | 3 | 0 | 3 |
| TMEM50B | FIBIN | 0.754087 | 4 | 0 | 3 |
| TMEM50B | MACROD2 | 0.746398 | 4 | 0 | 4 |
| TMEM50B | KBTBD4 | 0.741479 | 3 | 0 | 3 |
| TMEM50B | RABL3 | 0.732333 | 4 | 0 | 3 |
| TMEM50B | TBC1D20 | 0.729106 | 3 | 0 | 3 |
| TMEM50B | STAU2 | 0.727917 | 4 | 0 | 4 |
| TMEM50B | PRKAG1 | 0.724468 | 5 | 0 | 5 |
| TMEM50B | DMPK | 0.723086 | 3 | 0 | 3 |
| TMEM50B | EIF4E3 | 0.715585 | 7 | 0 | 7 |
| TMEM50B | IMMP2L | 0.713357 | 3 | 0 | 3 |
| TMEM50B | FAM83D | 0.711148 | 4 | 0 | 4 |
| TMEM50B | NUB1 | 0.710384 | 4 | 0 | 4 |
| TMEM50B | SMARCA2 | 0.709743 | 4 | 0 | 4 |
| TMEM50B | ZNF426 | 0.703812 | 3 | 0 | 3 |
| TMEM50B | EIF4G2 | 0.70238 | 3 | 0 | 3 |
For details and further investigation, click here
