| Full name: leucine carboxyl methyltransferase 1 | Alias Symbol: CGI-68|PPMT1 | ||
| Type: protein-coding gene | Cytoband: 16p12.1 | ||
| Entrez ID: 51451 | HGNC ID: HGNC:17557 | Ensembl Gene: ENSG00000205629 | OMIM ID: 610286 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LCMT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LCMT1 | 51451 | 221515_s_at | 0.2467 | 0.6462 | |
| GSE20347 | LCMT1 | 51451 | 221515_s_at | -0.1016 | 0.5341 | |
| GSE23400 | LCMT1 | 51451 | 221515_s_at | 0.1162 | 0.0574 | |
| GSE26886 | LCMT1 | 51451 | 221515_s_at | 0.0640 | 0.7170 | |
| GSE29001 | LCMT1 | 51451 | 221515_s_at | -0.1603 | 0.5910 | |
| GSE38129 | LCMT1 | 51451 | 221515_s_at | 0.0890 | 0.4439 | |
| GSE45670 | LCMT1 | 51451 | 221515_s_at | 0.0691 | 0.6134 | |
| GSE53622 | LCMT1 | 51451 | 153103 | -0.2035 | 0.0067 | |
| GSE53624 | LCMT1 | 51451 | 153103 | -0.1981 | 0.0011 | |
| GSE63941 | LCMT1 | 51451 | 221515_s_at | -0.1470 | 0.5033 | |
| GSE77861 | LCMT1 | 51451 | 221515_s_at | -0.0495 | 0.8841 | |
| GSE97050 | LCMT1 | 51451 | A_23_P112825 | 0.1581 | 0.6184 | |
| SRP007169 | LCMT1 | 51451 | RNAseq | -0.5103 | 0.2840 | |
| SRP064894 | LCMT1 | 51451 | RNAseq | -0.2670 | 0.2591 | |
| SRP133303 | LCMT1 | 51451 | RNAseq | -0.0244 | 0.8668 | |
| SRP159526 | LCMT1 | 51451 | RNAseq | 0.0271 | 0.8857 | |
| SRP193095 | LCMT1 | 51451 | RNAseq | -0.2855 | 0.0032 | |
| SRP219564 | LCMT1 | 51451 | RNAseq | 0.0567 | 0.8303 | |
| TCGA | LCMT1 | 51451 | RNAseq | 0.0515 | 0.3903 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LCMT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LCMT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LCMT1 | 51451 | 4 | 4 | 22 | |
| GSE20123 | LCMT1 | 51451 | 4 | 3 | 23 | |
| GSE43470 | LCMT1 | 51451 | 4 | 3 | 36 | |
| GSE46452 | LCMT1 | 51451 | 38 | 1 | 20 | |
| GSE47630 | LCMT1 | 51451 | 11 | 6 | 23 | |
| GSE54993 | LCMT1 | 51451 | 3 | 5 | 62 | |
| GSE54994 | LCMT1 | 51451 | 4 | 9 | 40 | |
| GSE60625 | LCMT1 | 51451 | 4 | 0 | 7 | |
| GSE74703 | LCMT1 | 51451 | 4 | 2 | 30 | |
| GSE74704 | LCMT1 | 51451 | 2 | 1 | 17 | |
| TCGA | LCMT1 | 51451 | 19 | 13 | 64 |
Total number of gains: 97; Total number of losses: 47; Total Number of normals: 344.
Somatic mutations of LCMT1:
Generating mutation plots.
Highly correlated genes for LCMT1:
Showing top 20/411 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LCMT1 | UBLCP1 | 0.783145 | 3 | 0 | 3 |
| LCMT1 | CMTM6 | 0.777096 | 3 | 0 | 3 |
| LCMT1 | NCOA6 | 0.775385 | 3 | 0 | 3 |
| LCMT1 | NAA20 | 0.761977 | 3 | 0 | 3 |
| LCMT1 | IER3IP1 | 0.752925 | 3 | 0 | 3 |
| LCMT1 | GPBP1L1 | 0.74188 | 3 | 0 | 3 |
| LCMT1 | LEMD2 | 0.738195 | 3 | 0 | 3 |
| LCMT1 | KDM2B | 0.737278 | 3 | 0 | 3 |
| LCMT1 | TBC1D22B | 0.727051 | 4 | 0 | 4 |
| LCMT1 | PPHLN1 | 0.727017 | 3 | 0 | 3 |
| LCMT1 | PPP6R2 | 0.724156 | 3 | 0 | 3 |
| LCMT1 | TBC1D23 | 0.721812 | 3 | 0 | 3 |
| LCMT1 | POLE3 | 0.713779 | 3 | 0 | 3 |
| LCMT1 | SSR1 | 0.713453 | 3 | 0 | 3 |
| LCMT1 | PTRHD1 | 0.706222 | 3 | 0 | 3 |
| LCMT1 | TRUB2 | 0.706208 | 3 | 0 | 3 |
| LCMT1 | RABIF | 0.705482 | 4 | 0 | 3 |
| LCMT1 | TOM1 | 0.700124 | 3 | 0 | 3 |
| LCMT1 | DTNBP1 | 0.700083 | 3 | 0 | 3 |
| LCMT1 | ZNF394 | 0.699553 | 3 | 0 | 3 |
For details and further investigation, click here
