| Full name: noggin | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q22 | ||
| Entrez ID: 9241 | HGNC ID: HGNC:7866 | Ensembl Gene: ENSG00000183691 | OMIM ID: 602991 |
| Drug and gene relationship at DGIdb | |||
NOG involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway |
Expression of NOG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NOG | 9241 | 231798_at | -0.1628 | 0.4210 | |
| GSE26886 | NOG | 9241 | 231798_at | -0.1152 | 0.6047 | |
| GSE45670 | NOG | 9241 | 231798_at | -0.5350 | 0.0002 | |
| GSE53622 | NOG | 9241 | 105508 | 0.1829 | 0.0638 | |
| GSE53624 | NOG | 9241 | 105508 | 0.1753 | 0.0512 | |
| GSE63941 | NOG | 9241 | 231798_at | -2.8857 | 0.0184 | |
| GSE77861 | NOG | 9241 | 231798_at | -0.1095 | 0.3194 | |
| GSE97050 | NOG | 9241 | A_33_P3391796 | 0.1627 | 0.4701 | |
| TCGA | NOG | 9241 | RNAseq | -0.0250 | 0.9561 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NOG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NOG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NOG | 9241 | 5 | 1 | 24 | |
| GSE20123 | NOG | 9241 | 5 | 1 | 24 | |
| GSE43470 | NOG | 9241 | 2 | 1 | 40 | |
| GSE46452 | NOG | 9241 | 32 | 0 | 27 | |
| GSE47630 | NOG | 9241 | 7 | 1 | 32 | |
| GSE54993 | NOG | 9241 | 2 | 4 | 64 | |
| GSE54994 | NOG | 9241 | 9 | 5 | 39 | |
| GSE60625 | NOG | 9241 | 4 | 0 | 7 | |
| GSE74703 | NOG | 9241 | 2 | 1 | 33 | |
| GSE74704 | NOG | 9241 | 4 | 1 | 15 | |
| TCGA | NOG | 9241 | 26 | 7 | 63 |
Total number of gains: 98; Total number of losses: 22; Total Number of normals: 368.
Somatic mutations of NOG:
Generating mutation plots.
Highly correlated genes for NOG:
Showing top 20/134 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NOG | SPACA1 | 0.788709 | 3 | 0 | 3 |
| NOG | SPNS3 | 0.770222 | 3 | 0 | 3 |
| NOG | MUC8 | 0.758943 | 3 | 0 | 3 |
| NOG | LACRT | 0.738856 | 3 | 0 | 3 |
| NOG | PRRG3 | 0.736498 | 3 | 0 | 3 |
| NOG | ITIH3 | 0.734482 | 3 | 0 | 3 |
| NOG | MOB1B | 0.73377 | 3 | 0 | 3 |
| NOG | ACTC1 | 0.729155 | 3 | 0 | 3 |
| NOG | OR2C1 | 0.727276 | 3 | 0 | 3 |
| NOG | SCN3A | 0.726673 | 3 | 0 | 3 |
| NOG | RIIAD1 | 0.725809 | 3 | 0 | 3 |
| NOG | ACSM2B | 0.717028 | 3 | 0 | 3 |
| NOG | ZFPM2 | 0.7063 | 3 | 0 | 3 |
| NOG | BSND | 0.706145 | 3 | 0 | 3 |
| NOG | GREM2 | 0.704331 | 3 | 0 | 3 |
| NOG | ENPP1 | 0.700877 | 4 | 0 | 4 |
| NOG | TMEM221 | 0.698981 | 3 | 0 | 3 |
| NOG | ZNF582 | 0.698109 | 3 | 0 | 3 |
| NOG | MAGEE1 | 0.694876 | 3 | 0 | 3 |
| NOG | FNDC9 | 0.691469 | 3 | 0 | 3 |
For details and further investigation, click here
