| Full name: sodium voltage-gated channel alpha subunit 3 | Alias Symbol: Nav1.3 | ||
| Type: protein-coding gene | Cytoband: 2q24.3 | ||
| Entrez ID: 6328 | HGNC ID: HGNC:10590 | Ensembl Gene: ENSG00000153253 | OMIM ID: 182391 |
| Drug and gene relationship at DGIdb | |||
SCN3A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04742 | Taste transduction |
Expression of SCN3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCN3A | 6328 | 210432_s_at | -0.6475 | 0.2950 | |
| GSE20347 | SCN3A | 6328 | 210432_s_at | -0.0190 | 0.8627 | |
| GSE23400 | SCN3A | 6328 | 210432_s_at | -0.0506 | 0.1744 | |
| GSE29001 | SCN3A | 6328 | 210432_s_at | 0.0003 | 0.9994 | |
| GSE38129 | SCN3A | 6328 | 210432_s_at | -0.2953 | 0.5282 | |
| GSE53622 | SCN3A | 6328 | 63985 | -0.2276 | 0.0042 | |
| GSE53624 | SCN3A | 6328 | 63985 | 0.3686 | 0.0000 | |
| GSE63941 | SCN3A | 6328 | 210432_s_at | -5.0237 | 0.0000 | |
| GSE97050 | SCN3A | 6328 | A_23_P67896 | 0.2053 | 0.3338 | |
| SRP133303 | SCN3A | 6328 | RNAseq | 1.7159 | 0.0002 | |
| SRP159526 | SCN3A | 6328 | RNAseq | -0.0336 | 0.9667 | |
| SRP219564 | SCN3A | 6328 | RNAseq | -0.3449 | 0.6594 | |
| TCGA | SCN3A | 6328 | RNAseq | -1.2486 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by SCN3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCN3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCN3A | 6328 | 6 | 1 | 23 | |
| GSE20123 | SCN3A | 6328 | 6 | 1 | 23 | |
| GSE43470 | SCN3A | 6328 | 5 | 1 | 37 | |
| GSE46452 | SCN3A | 6328 | 1 | 4 | 54 | |
| GSE47630 | SCN3A | 6328 | 5 | 3 | 32 | |
| GSE54993 | SCN3A | 6328 | 0 | 5 | 65 | |
| GSE54994 | SCN3A | 6328 | 11 | 2 | 40 | |
| GSE60625 | SCN3A | 6328 | 0 | 3 | 8 | |
| GSE74703 | SCN3A | 6328 | 4 | 1 | 31 | |
| GSE74704 | SCN3A | 6328 | 3 | 0 | 17 | |
| TCGA | SCN3A | 6328 | 24 | 9 | 63 |
Total number of gains: 65; Total number of losses: 30; Total Number of normals: 393.
Somatic mutations of SCN3A:
Generating mutation plots.
Highly correlated genes for SCN3A:
Showing top 20/162 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCN3A | C16orf89 | 0.776516 | 3 | 0 | 3 |
| SCN3A | ZCCHC18 | 0.756109 | 3 | 0 | 3 |
| SCN3A | MFNG | 0.751429 | 3 | 0 | 3 |
| SCN3A | SETDB2 | 0.750499 | 3 | 0 | 3 |
| SCN3A | CNTN4 | 0.749409 | 3 | 0 | 3 |
| SCN3A | PGLYRP1 | 0.742471 | 3 | 0 | 3 |
| SCN3A | SHC3 | 0.741496 | 4 | 0 | 3 |
| SCN3A | PDZRN3 | 0.741107 | 4 | 0 | 3 |
| SCN3A | NOG | 0.726673 | 3 | 0 | 3 |
| SCN3A | ATOH8 | 0.723474 | 4 | 0 | 4 |
| SCN3A | PNMA2 | 0.712606 | 4 | 0 | 3 |
| SCN3A | TCEAL7 | 0.711947 | 4 | 0 | 3 |
| SCN3A | SCN9A | 0.71186 | 4 | 0 | 3 |
| SCN3A | TRPA1 | 0.706623 | 4 | 0 | 3 |
| SCN3A | CCR6 | 0.705803 | 3 | 0 | 3 |
| SCN3A | OR1F1 | 0.699562 | 3 | 0 | 3 |
| SCN3A | LSAMP | 0.699426 | 3 | 0 | 3 |
| SCN3A | TESC | 0.695661 | 4 | 0 | 4 |
| SCN3A | LOXL3 | 0.693311 | 3 | 0 | 3 |
| SCN3A | CCL13 | 0.692273 | 5 | 0 | 4 |
For details and further investigation, click here
