| Full name: gremlin 2, DAN family BMP antagonist | Alias Symbol: Prdc|FLJ21195|CKTSF1B2|DAND3 | ||
| Type: protein-coding gene | Cytoband: 1q43 | ||
| Entrez ID: 64388 | HGNC ID: HGNC:17655 | Ensembl Gene: ENSG00000180875 | OMIM ID: 608832 |
| Drug and gene relationship at DGIdb | |||
Expression of GREM2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GREM2 | 64388 | 220794_at | -2.5269 | 0.0132 | |
| GSE20347 | GREM2 | 64388 | 220794_at | -0.4170 | 0.0018 | |
| GSE23400 | GREM2 | 64388 | 220794_at | -0.3749 | 0.0000 | |
| GSE26886 | GREM2 | 64388 | 235504_at | -0.1528 | 0.4637 | |
| GSE29001 | GREM2 | 64388 | 220794_at | -0.5268 | 0.0526 | |
| GSE38129 | GREM2 | 64388 | 220794_at | -1.2450 | 0.0000 | |
| GSE45670 | GREM2 | 64388 | 235504_at | -1.9506 | 0.0000 | |
| GSE53622 | GREM2 | 64388 | 95359 | -2.4841 | 0.0000 | |
| GSE53624 | GREM2 | 64388 | 95359 | -2.2115 | 0.0000 | |
| GSE63941 | GREM2 | 64388 | 235504_at | -5.2279 | 0.0000 | |
| GSE77861 | GREM2 | 64388 | 235504_at | -0.0679 | 0.5257 | |
| GSE97050 | GREM2 | 64388 | A_24_P40626 | -0.2500 | 0.7378 | |
| SRP064894 | GREM2 | 64388 | RNAseq | -3.3649 | 0.0000 | |
| SRP133303 | GREM2 | 64388 | RNAseq | -2.6144 | 0.0000 | |
| SRP159526 | GREM2 | 64388 | RNAseq | -2.0581 | 0.0051 | |
| SRP193095 | GREM2 | 64388 | RNAseq | -0.2106 | 0.5281 | |
| SRP219564 | GREM2 | 64388 | RNAseq | -0.9906 | 0.3623 | |
| TCGA | GREM2 | 64388 | RNAseq | -1.8454 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by GREM2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GREM2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GREM2 | 64388 | 8 | 1 | 21 | |
| GSE20123 | GREM2 | 64388 | 8 | 1 | 21 | |
| GSE43470 | GREM2 | 64388 | 6 | 1 | 36 | |
| GSE46452 | GREM2 | 64388 | 4 | 2 | 53 | |
| GSE47630 | GREM2 | 64388 | 15 | 0 | 25 | |
| GSE54993 | GREM2 | 64388 | 0 | 6 | 64 | |
| GSE54994 | GREM2 | 64388 | 16 | 0 | 37 | |
| GSE60625 | GREM2 | 64388 | 0 | 0 | 11 | |
| GSE74703 | GREM2 | 64388 | 6 | 1 | 29 | |
| GSE74704 | GREM2 | 64388 | 2 | 0 | 18 | |
| TCGA | GREM2 | 64388 | 44 | 4 | 48 |
Total number of gains: 109; Total number of losses: 16; Total Number of normals: 363.
Somatic mutations of GREM2:
Generating mutation plots.
Highly correlated genes for GREM2:
Showing top 20/1046 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GREM2 | LINC01082 | 0.887224 | 5 | 0 | 5 |
| GREM2 | ANGPTL1 | 0.806866 | 6 | 0 | 6 |
| GREM2 | FENDRR | 0.801491 | 5 | 0 | 5 |
| GREM2 | TBX5-AS1 | 0.801214 | 3 | 0 | 3 |
| GREM2 | ITGA1 | 0.783922 | 4 | 0 | 4 |
| GREM2 | PGM5-AS1 | 0.776513 | 4 | 0 | 3 |
| GREM2 | NEGR1 | 0.773237 | 7 | 0 | 6 |
| GREM2 | LGI1 | 0.771961 | 9 | 0 | 9 |
| GREM2 | RSPO1 | 0.768517 | 5 | 0 | 5 |
| GREM2 | PLCXD3 | 0.76508 | 4 | 0 | 4 |
| GREM2 | LINC01279 | 0.763798 | 4 | 0 | 4 |
| GREM2 | RCAN2 | 0.76275 | 10 | 0 | 9 |
| GREM2 | RGS7BP | 0.754881 | 5 | 0 | 5 |
| GREM2 | HMCN1 | 0.75445 | 3 | 0 | 3 |
| GREM2 | ASPA | 0.753058 | 11 | 0 | 10 |
| GREM2 | MAGI2-AS3 | 0.747553 | 5 | 0 | 5 |
| GREM2 | SYNPO2 | 0.746038 | 6 | 0 | 5 |
| GREM2 | SH3BGRL2 | 0.74518 | 4 | 0 | 4 |
| GREM2 | OGN | 0.741825 | 9 | 0 | 8 |
| GREM2 | LMOD1 | 0.741624 | 10 | 0 | 9 |
For details and further investigation, click here
