| Full name: MOB kinase activator 1B | Alias Symbol: MOB4A | ||
| Type: protein-coding gene | Cytoband: 4q13.3 | ||
| Entrez ID: 92597 | HGNC ID: HGNC:29801 | Ensembl Gene: ENSG00000173542 | OMIM ID: 609282 |
| Drug and gene relationship at DGIdb | |||
MOB1B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04390 | Hippo signaling pathway |
Expression of MOB1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MOB1B | 92597 | 225997_at | -0.0013 | 0.9987 | |
| GSE26886 | MOB1B | 92597 | 225997_at | -0.4535 | 0.2267 | |
| GSE45670 | MOB1B | 92597 | 225997_at | -0.4850 | 0.0046 | |
| GSE53622 | MOB1B | 92597 | 94008 | -0.1017 | 0.0251 | |
| GSE53624 | MOB1B | 92597 | 94008 | 0.1508 | 0.0013 | |
| GSE63941 | MOB1B | 92597 | 225997_at | -1.6188 | 0.0047 | |
| GSE77861 | MOB1B | 92597 | 225997_at | -0.3174 | 0.2581 | |
| GSE97050 | MOB1B | 92597 | A_33_P3347622 | 0.0028 | 0.9904 | |
| SRP007169 | MOB1B | 92597 | RNAseq | 0.6846 | 0.0863 | |
| SRP008496 | MOB1B | 92597 | RNAseq | 1.0620 | 0.0001 | |
| SRP064894 | MOB1B | 92597 | RNAseq | -0.0025 | 0.9912 | |
| SRP133303 | MOB1B | 92597 | RNAseq | 0.2344 | 0.1303 | |
| SRP159526 | MOB1B | 92597 | RNAseq | -0.1443 | 0.6262 | |
| SRP193095 | MOB1B | 92597 | RNAseq | -0.1262 | 0.1342 | |
| SRP219564 | MOB1B | 92597 | RNAseq | -0.2172 | 0.3321 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by MOB1B expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of MOB1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MOB1B | 92597 | 0 | 11 | 19 | |
| GSE20123 | MOB1B | 92597 | 0 | 11 | 19 | |
| GSE43470 | MOB1B | 92597 | 0 | 13 | 30 | |
| GSE46452 | MOB1B | 92597 | 2 | 35 | 22 | |
| GSE47630 | MOB1B | 92597 | 1 | 19 | 20 | |
| GSE54993 | MOB1B | 92597 | 7 | 0 | 63 | |
| GSE54994 | MOB1B | 92597 | 1 | 9 | 43 | |
| GSE60625 | MOB1B | 92597 | 0 | 0 | 11 | |
| GSE74703 | MOB1B | 92597 | 0 | 11 | 25 | |
| GSE74704 | MOB1B | 92597 | 0 | 6 | 14 | |
| TCGA | MOB1B | 92597 | 16 | 28 | 52 |
Total number of gains: 27; Total number of losses: 143; Total Number of normals: 318.
Somatic mutations of MOB1B:
Generating mutation plots.
Highly correlated genes for MOB1B:
Showing top 20/53 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MOB1B | MYO1C | 0.781673 | 3 | 0 | 3 |
| MOB1B | NOG | 0.73377 | 3 | 0 | 3 |
| MOB1B | PRRG1 | 0.73154 | 3 | 0 | 3 |
| MOB1B | TUSC1 | 0.727321 | 3 | 0 | 3 |
| MOB1B | PEX7 | 0.726121 | 3 | 0 | 3 |
| MOB1B | COX18 | 0.716358 | 3 | 0 | 3 |
| MOB1B | KRTAP10-2 | 0.713166 | 3 | 0 | 3 |
| MOB1B | PAFAH1B1 | 0.690382 | 4 | 0 | 4 |
| MOB1B | D2HGDH | 0.690294 | 4 | 0 | 3 |
| MOB1B | RASSF1 | 0.668061 | 3 | 0 | 3 |
| MOB1B | TMCO3 | 0.665831 | 3 | 0 | 3 |
| MOB1B | TIGD7 | 0.662018 | 3 | 0 | 3 |
| MOB1B | SLC4A7 | 0.65863 | 3 | 0 | 3 |
| MOB1B | SIRPA | 0.648327 | 3 | 0 | 3 |
| MOB1B | ZNF329 | 0.635659 | 4 | 0 | 3 |
| MOB1B | CEP135 | 0.633872 | 4 | 0 | 4 |
| MOB1B | CCDC186 | 0.631897 | 3 | 0 | 3 |
| MOB1B | CENPC | 0.620266 | 4 | 0 | 3 |
| MOB1B | GNRH1 | 0.604765 | 4 | 0 | 3 |
| MOB1B | MAML3 | 0.604336 | 4 | 0 | 4 |
For details and further investigation, click here
