| Full name: toll like receptor 9 | Alias Symbol: CD289 | ||
| Type: protein-coding gene | Cytoband: 3p21.2 | ||
| Entrez ID: 54106 | HGNC ID: HGNC:15633 | Ensembl Gene: ENSG00000239732 | OMIM ID: 605474 |
| Drug and gene relationship at DGIdb | |||
TLR9 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04620 | Toll-like receptor signaling pathway | |
| hsa05142 | Chagas disease (American trypanosomiasis) | |
| hsa05152 | Tuberculosis | |
| hsa05162 | Measles | |
| hsa05168 | Herpes simplex infection |
Expression of TLR9:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLR9 | 54106 | 223903_at | 0.1680 | 0.5570 | |
| GSE26886 | TLR9 | 54106 | 223903_at | 0.0444 | 0.7749 | |
| GSE45670 | TLR9 | 54106 | 223903_at | 0.0523 | 0.5414 | |
| GSE63941 | TLR9 | 54106 | 223903_at | 0.0643 | 0.6878 | |
| GSE77861 | TLR9 | 54106 | 223903_at | 0.0720 | 0.5475 | |
| GSE97050 | TLR9 | 54106 | A_33_P3380807 | 0.6317 | 0.1368 | |
| SRP133303 | TLR9 | 54106 | RNAseq | -0.5163 | 0.1441 | |
| SRP159526 | TLR9 | 54106 | RNAseq | -0.9706 | 0.1044 | |
| SRP219564 | TLR9 | 54106 | RNAseq | -0.5718 | 0.2620 | |
| TCGA | TLR9 | 54106 | RNAseq | -0.5645 | 0.0147 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TLR9 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of TLR9:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLR9 | 54106 | 0 | 18 | 12 | |
| GSE20123 | TLR9 | 54106 | 0 | 19 | 11 | |
| GSE43470 | TLR9 | 54106 | 0 | 18 | 25 | |
| GSE46452 | TLR9 | 54106 | 2 | 17 | 40 | |
| GSE47630 | TLR9 | 54106 | 1 | 24 | 15 | |
| GSE54993 | TLR9 | 54106 | 6 | 2 | 62 | |
| GSE54994 | TLR9 | 54106 | 0 | 34 | 19 | |
| GSE60625 | TLR9 | 54106 | 5 | 0 | 6 | |
| GSE74703 | TLR9 | 54106 | 0 | 14 | 22 | |
| GSE74704 | TLR9 | 54106 | 0 | 12 | 8 | |
| TCGA | TLR9 | 54106 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 236; Total Number of normals: 238.
Somatic mutations of TLR9:
Generating mutation plots.
Highly correlated genes for TLR9:
Showing top 20/86 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLR9 | NCR3 | 0.777153 | 3 | 0 | 3 |
| TLR9 | CCL26 | 0.74722 | 3 | 0 | 3 |
| TLR9 | ASTN2 | 0.732843 | 3 | 0 | 3 |
| TLR9 | EVX1 | 0.724276 | 3 | 0 | 3 |
| TLR9 | ABCC2 | 0.720694 | 4 | 0 | 4 |
| TLR9 | C19orf73 | 0.716987 | 3 | 0 | 3 |
| TLR9 | NPAS1 | 0.714901 | 3 | 0 | 3 |
| TLR9 | ALPL | 0.712252 | 3 | 0 | 3 |
| TLR9 | C10orf91 | 0.707332 | 4 | 0 | 3 |
| TLR9 | TRPM2-AS | 0.705651 | 3 | 0 | 3 |
| TLR9 | BANP | 0.703822 | 3 | 0 | 3 |
| TLR9 | TSSK3 | 0.702072 | 3 | 0 | 3 |
| TLR9 | LILRA3 | 0.69871 | 3 | 0 | 3 |
| TLR9 | C16orf95 | 0.698523 | 3 | 0 | 3 |
| TLR9 | TM6SF2 | 0.69502 | 4 | 0 | 3 |
| TLR9 | CFC1 | 0.689275 | 3 | 0 | 3 |
| TLR9 | AANAT | 0.68894 | 3 | 0 | 3 |
| TLR9 | BAHCC1 | 0.681232 | 3 | 0 | 3 |
| TLR9 | PSPN | 0.673112 | 3 | 0 | 3 |
| TLR9 | TBX2 | 0.672673 | 3 | 0 | 3 |
For details and further investigation, click here
