| Full name: ribonuclease P/MRP subunit p38 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10p13 | ||
| Entrez ID: 10557 | HGNC ID: HGNC:30329 | Ensembl Gene: ENSG00000152464 | OMIM ID: 606116 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RPP38:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPP38 | 10557 | 205562_at | 0.1720 | 0.6044 | |
| GSE20347 | RPP38 | 10557 | 205562_at | 0.0223 | 0.8619 | |
| GSE23400 | RPP38 | 10557 | 205562_at | 0.1035 | 0.0307 | |
| GSE26886 | RPP38 | 10557 | 205562_at | 0.2638 | 0.2291 | |
| GSE29001 | RPP38 | 10557 | 205562_at | -0.0129 | 0.9632 | |
| GSE38129 | RPP38 | 10557 | 205562_at | 0.0966 | 0.3593 | |
| GSE45670 | RPP38 | 10557 | 205562_at | 0.0411 | 0.7931 | |
| GSE53622 | RPP38 | 10557 | 84677 | 0.3167 | 0.0000 | |
| GSE53624 | RPP38 | 10557 | 84677 | 0.1283 | 0.0283 | |
| GSE63941 | RPP38 | 10557 | 205562_at | 1.0654 | 0.0073 | |
| GSE77861 | RPP38 | 10557 | 205562_at | -0.0093 | 0.9691 | |
| GSE97050 | RPP38 | 10557 | A_23_P150080 | 0.5863 | 0.1241 | |
| SRP007169 | RPP38 | 10557 | RNAseq | -0.6966 | 0.1100 | |
| SRP008496 | RPP38 | 10557 | RNAseq | -0.5205 | 0.0772 | |
| SRP064894 | RPP38 | 10557 | RNAseq | -0.0035 | 0.9851 | |
| SRP133303 | RPP38 | 10557 | RNAseq | -0.0947 | 0.4236 | |
| SRP159526 | RPP38 | 10557 | RNAseq | -0.0468 | 0.9047 | |
| SRP193095 | RPP38 | 10557 | RNAseq | -0.0739 | 0.3754 | |
| SRP219564 | RPP38 | 10557 | RNAseq | -0.3160 | 0.1959 | |
| TCGA | RPP38 | 10557 | RNAseq | 0.0673 | 0.3032 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by RPP38 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPP38:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPP38 | 10557 | 3 | 8 | 19 | |
| GSE20123 | RPP38 | 10557 | 3 | 7 | 20 | |
| GSE43470 | RPP38 | 10557 | 3 | 5 | 35 | |
| GSE46452 | RPP38 | 10557 | 1 | 14 | 44 | |
| GSE47630 | RPP38 | 10557 | 5 | 15 | 20 | |
| GSE54993 | RPP38 | 10557 | 10 | 0 | 60 | |
| GSE54994 | RPP38 | 10557 | 4 | 9 | 40 | |
| GSE60625 | RPP38 | 10557 | 0 | 0 | 11 | |
| GSE74703 | RPP38 | 10557 | 2 | 3 | 31 | |
| GSE74704 | RPP38 | 10557 | 0 | 6 | 14 | |
| TCGA | RPP38 | 10557 | 20 | 25 | 51 |
Total number of gains: 51; Total number of losses: 92; Total Number of normals: 345.
Somatic mutations of RPP38:
Generating mutation plots.
Highly correlated genes for RPP38:
Showing top 20/602 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPP38 | CHCHD5 | 0.86229 | 3 | 0 | 3 |
| RPP38 | PARG | 0.860167 | 3 | 0 | 3 |
| RPP38 | CNOT10 | 0.859027 | 3 | 0 | 3 |
| RPP38 | NFKB1 | 0.817774 | 3 | 0 | 3 |
| RPP38 | TBL2 | 0.816884 | 3 | 0 | 3 |
| RPP38 | COMMD2 | 0.81595 | 3 | 0 | 3 |
| RPP38 | CSTF2T | 0.808777 | 3 | 0 | 3 |
| RPP38 | C1orf174 | 0.798586 | 3 | 0 | 3 |
| RPP38 | TMED5 | 0.797084 | 3 | 0 | 3 |
| RPP38 | INTS12 | 0.791522 | 4 | 0 | 4 |
| RPP38 | UNC5CL | 0.788453 | 3 | 0 | 3 |
| RPP38 | CSNK2B | 0.788258 | 3 | 0 | 3 |
| RPP38 | API5 | 0.787248 | 3 | 0 | 3 |
| RPP38 | TFIP11 | 0.779057 | 3 | 0 | 3 |
| RPP38 | HMGB2 | 0.772669 | 3 | 0 | 3 |
| RPP38 | PRDM15 | 0.771093 | 3 | 0 | 3 |
| RPP38 | CLCN5 | 0.771058 | 3 | 0 | 3 |
| RPP38 | MGAT4A | 0.757636 | 3 | 0 | 3 |
| RPP38 | ZDHHC16 | 0.756858 | 4 | 0 | 4 |
| RPP38 | ERCC8 | 0.747289 | 3 | 0 | 3 |
For details and further investigation, click here
