TCF7L2

 

Full name: transcription factor 7 like 2 Alias Symbol: TCF-4
Type: protein-coding gene Cytoband: 10q25.2-q25.3
Entrez ID: 6934 HGNC ID: HGNC:11641 Ensembl Gene: ENSG00000148737 OMIM ID: 602228
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 17/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

TCF7L2 involved pathways:

KEGG pathway Description View
hsa04310Wnt signaling pathway
hsa04390Hippo signaling pathway
hsa04520Adherens junction
hsa04916Melanogenesis
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa05216Thyroid cancer
hsa05217Basal cell carcinoma
hsa05221Acute myeloid leukemia

 

Expression of TCF7L2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TCF7L2 6934 212761_at -0.2271 0.6137
GSE20347 TCF7L2 6934 212761_at 0.0423 0.8700
GSE23400 TCF7L2 6934 212761_at 0.0691 0.4936
GSE26886 TCF7L2 6934 212761_at 0.9331 0.0003
GSE29001 TCF7L2 6934 212761_at 0.2155 0.2700
GSE38129 TCF7L2 6934 212761_at -0.1382 0.4370
GSE45670 TCF7L2 6934 212761_at -0.7024 0.0003
GSE53622 TCF7L2 6934 48686 -0.0161 0.8622
GSE53624 TCF7L2 6934 120084 0.1214 0.0640
GSE63941 TCF7L2 6934 212761_at -0.4185 0.3194
GSE77861 TCF7L2 6934 212761_at 0.5021 0.2390
GSE97050 TCF7L2 6934 A_33_P3377304 0.2864 0.2942
SRP007169 TCF7L2 6934 RNAseq 0.6789 0.1502
SRP008496 TCF7L2 6934 RNAseq 0.9984 0.0047
SRP064894 TCF7L2 6934 RNAseq -0.1080 0.5118
SRP133303 TCF7L2 6934 RNAseq 0.1446 0.4007
SRP159526 TCF7L2 6934 RNAseq 0.0328 0.8905
SRP193095 TCF7L2 6934 RNAseq 0.1933 0.4885
SRP219564 TCF7L2 6934 RNAseq 0.1130 0.6726
TCGA TCF7L2 6934 RNAseq -0.1306 0.0260

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TCF7L2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TCF7L2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TCF7L2 6934 1 8 21
GSE20123 TCF7L2 6934 1 7 22
GSE43470 TCF7L2 6934 0 9 34
GSE46452 TCF7L2 6934 0 11 48
GSE47630 TCF7L2 6934 2 14 24
GSE54993 TCF7L2 6934 8 0 62
GSE54994 TCF7L2 6934 1 10 42
GSE60625 TCF7L2 6934 0 0 11
GSE74703 TCF7L2 6934 0 6 30
GSE74704 TCF7L2 6934 1 3 16
TCGA TCF7L2 6934 4 29 63

Total number of gains: 18; Total number of losses: 97; Total Number of normals: 373.  

 

Somatic mutations of TCF7L2:

 

Generating mutation plots.

 

Highly correlated genes for TCF7L2:

 

Showing top 20/496 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TCF7L2TMED80.808124303
TCF7L2EIF2D0.805361303
TCF7L2HNRNPA10.798493303
TCF7L2ANAPC100.792701303
TCF7L2SPICE10.786724303
TCF7L2SLC39A100.77263303
TCF7L2ZFP900.768234303
TCF7L2ZNF440.762286303
TCF7L2ZNF7660.759571303
TCF7L2BRD90.759505303
TCF7L2POLR2J0.757108303
TCF7L2ZCCHC70.756017303
TCF7L2EFCAB70.753628404
TCF7L2TATDN10.750083303
TCF7L2TIMM90.749918303
TCF7L2NSMCE20.736523303
TCF7L2DOCK50.736173303
TCF7L2TIMP10.736023303
TCF7L2ZNF6150.733667303
TCF7L2SIX40.732206303

For details and further investigation, click here