| Full name: NFS1 cysteine desulfurase | Alias Symbol: NifS|IscS | ||
| Type: protein-coding gene | Cytoband: 20q11.22 | ||
| Entrez ID: 9054 | HGNC ID: HGNC:15910 | Ensembl Gene: ENSG00000244005 | OMIM ID: 603485 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NFS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NFS1 | 9054 | 218455_at | 0.8705 | 0.1166 | |
| GSE20347 | NFS1 | 9054 | 218455_at | 0.6963 | 0.0001 | |
| GSE23400 | NFS1 | 9054 | 218455_at | 0.4071 | 0.0000 | |
| GSE26886 | NFS1 | 9054 | 218455_at | -0.1434 | 0.4348 | |
| GSE29001 | NFS1 | 9054 | 218455_at | 0.8328 | 0.0025 | |
| GSE38129 | NFS1 | 9054 | 218455_at | 0.5765 | 0.0000 | |
| GSE45670 | NFS1 | 9054 | 218455_at | 0.4993 | 0.0019 | |
| GSE53622 | NFS1 | 9054 | 28144 | 0.6714 | 0.0000 | |
| GSE53624 | NFS1 | 9054 | 102415 | 0.5034 | 0.0000 | |
| GSE63941 | NFS1 | 9054 | 218455_at | 0.4376 | 0.2726 | |
| GSE77861 | NFS1 | 9054 | 218455_at | 0.4251 | 0.0538 | |
| GSE97050 | NFS1 | 9054 | A_33_P3298634 | 0.4914 | 0.2371 | |
| SRP007169 | NFS1 | 9054 | RNAseq | 0.3457 | 0.3329 | |
| SRP008496 | NFS1 | 9054 | RNAseq | 0.3396 | 0.2009 | |
| SRP064894 | NFS1 | 9054 | RNAseq | 0.5902 | 0.0001 | |
| SRP133303 | NFS1 | 9054 | RNAseq | 0.4634 | 0.0000 | |
| SRP159526 | NFS1 | 9054 | RNAseq | 0.3563 | 0.0713 | |
| SRP193095 | NFS1 | 9054 | RNAseq | 0.3248 | 0.0000 | |
| SRP219564 | NFS1 | 9054 | RNAseq | 0.4887 | 0.2503 | |
| TCGA | NFS1 | 9054 | RNAseq | 0.0264 | 0.6328 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NFS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NFS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NFS1 | 9054 | 15 | 1 | 14 | |
| GSE20123 | NFS1 | 9054 | 15 | 1 | 14 | |
| GSE43470 | NFS1 | 9054 | 12 | 0 | 31 | |
| GSE46452 | NFS1 | 9054 | 29 | 0 | 30 | |
| GSE47630 | NFS1 | 9054 | 25 | 0 | 15 | |
| GSE54993 | NFS1 | 9054 | 0 | 17 | 53 | |
| GSE54994 | NFS1 | 9054 | 24 | 0 | 29 | |
| GSE60625 | NFS1 | 9054 | 0 | 0 | 11 | |
| GSE74703 | NFS1 | 9054 | 11 | 0 | 25 | |
| GSE74704 | NFS1 | 9054 | 11 | 0 | 9 | |
| TCGA | NFS1 | 9054 | 49 | 3 | 44 |
Total number of gains: 191; Total number of losses: 22; Total Number of normals: 275.
Somatic mutations of NFS1:
Generating mutation plots.
Highly correlated genes for NFS1:
Showing top 20/1275 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NFS1 | SLC7A6OS | 0.747973 | 4 | 0 | 3 |
| NFS1 | PET117 | 0.739466 | 4 | 0 | 4 |
| NFS1 | MRPS5 | 0.733689 | 3 | 0 | 3 |
| NFS1 | LRRCC1 | 0.733279 | 4 | 0 | 4 |
| NFS1 | DHX33 | 0.723978 | 5 | 0 | 5 |
| NFS1 | PPTC7 | 0.723211 | 4 | 0 | 3 |
| NFS1 | MRGBP | 0.722437 | 9 | 0 | 9 |
| NFS1 | EDEM2 | 0.718044 | 10 | 0 | 9 |
| NFS1 | YTHDF1 | 0.717206 | 11 | 0 | 10 |
| NFS1 | NSMCE2 | 0.716817 | 4 | 0 | 4 |
| NFS1 | METTL15 | 0.715306 | 3 | 0 | 3 |
| NFS1 | SPATA5 | 0.714974 | 3 | 0 | 3 |
| NFS1 | TP53RK | 0.712867 | 4 | 0 | 3 |
| NFS1 | MTO1 | 0.708575 | 4 | 0 | 3 |
| NFS1 | MAPKAPK5 | 0.704126 | 10 | 0 | 10 |
| NFS1 | RPN2 | 0.703776 | 10 | 0 | 9 |
| NFS1 | TMEM179B | 0.701979 | 3 | 0 | 3 |
| NFS1 | WDR5 | 0.696657 | 3 | 0 | 3 |
| NFS1 | PIGU | 0.696123 | 8 | 0 | 7 |
| NFS1 | EBNA1BP2 | 0.695672 | 3 | 0 | 3 |
For details and further investigation, click here
