PLCG1

 

Full name: phospholipase C gamma 1 Alias Symbol: PLC148|PLC-II|PLCgamma1|NCKAP3
Type: protein-coding gene Cytoband: 20q12
Entrez ID: 5335 HGNC ID: HGNC:9065 Ensembl Gene: ENSG00000124181 OMIM ID: 172420
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

PLCG1 involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04066HIF-1 signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04750Inflammatory mediator regulation of TRP channels
hsa04919Thyroid hormone signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05110Vibrio cholerae infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05214Glioma
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of PLCG1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PLCG1 5335 202789_at 0.6416 0.1033
GSE20347 PLCG1 5335 202789_at 0.4510 0.0000
GSE23400 PLCG1 5335 202789_at 0.3587 0.0000
GSE26886 PLCG1 5335 202789_at 0.7844 0.0001
GSE29001 PLCG1 5335 202789_at 0.8438 0.0210
GSE38129 PLCG1 5335 202789_at 0.3133 0.0638
GSE45670 PLCG1 5335 202789_at 0.1667 0.2439
GSE53622 PLCG1 5335 68457 0.2754 0.0440
GSE53624 PLCG1 5335 68457 0.2506 0.0121
GSE63941 PLCG1 5335 202789_at -0.4385 0.3303
GSE77861 PLCG1 5335 216551_x_at 0.0131 0.9160
GSE97050 PLCG1 5335 A_23_P254801 -0.1413 0.6642
SRP007169 PLCG1 5335 RNAseq 0.9236 0.0334
SRP008496 PLCG1 5335 RNAseq 1.2057 0.0000
SRP064894 PLCG1 5335 RNAseq 0.7449 0.0000
SRP133303 PLCG1 5335 RNAseq 0.3657 0.0119
SRP159526 PLCG1 5335 RNAseq 0.7570 0.1412
SRP193095 PLCG1 5335 RNAseq 0.8304 0.0000
SRP219564 PLCG1 5335 RNAseq 0.4297 0.1849
TCGA PLCG1 5335 RNAseq 0.0839 0.0989

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by PLCG1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PLCG1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PLCG1 5335 13 1 16
GSE20123 PLCG1 5335 13 1 16
GSE43470 PLCG1 5335 13 0 30
GSE46452 PLCG1 5335 29 0 30
GSE47630 PLCG1 5335 24 0 16
GSE54993 PLCG1 5335 0 17 53
GSE54994 PLCG1 5335 24 0 29
GSE60625 PLCG1 5335 0 0 11
GSE74703 PLCG1 5335 10 0 26
GSE74704 PLCG1 5335 9 0 11
TCGA PLCG1 5335 45 5 46

Total number of gains: 180; Total number of losses: 24; Total Number of normals: 284.  

 

Somatic mutations of PLCG1:

 

Generating mutation plots.

 

Highly correlated genes for PLCG1:

 

Showing top 20/1346 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PLCG1ROMO10.796897303
PLCG1ACBD60.783258303
PLCG1NSMCE20.782523303
PLCG1SIN3A0.776438303
PLCG1TMEM14B0.77328303
PLCG1LSM100.772164303
PLCG1GEMIN50.772085303
PLCG1BZW20.769242404
PLCG1CTU20.762841303
PLCG1DGCR20.76043303
PLCG1RPL190.756296303
PLCG1RPL80.754666404
PLCG1COMMD50.753205303
PLCG1RIOK10.752382303
PLCG1ARFRP10.751553505
PLCG1PET1170.749359403
PLCG1WDR810.743998303
PLCG1NOP580.743041303
PLCG1NEK60.740992303
PLCG1SEC22A0.73642404

For details and further investigation, click here