NSUN5

 

Full name: NOP2/Sun RNA methyltransferase 5 Alias Symbol: NOL1R|p120(NOL1)|FLJ10267|NSUN5A|Ynl022cL
Type: protein-coding gene Cytoband: 7q11.23
Entrez ID: 55695 HGNC ID: HGNC:16385 Ensembl Gene: ENSG00000130305 OMIM ID: 615732
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of NSUN5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NSUN5 55695 213773_x_at 0.5208 0.1962
GSE20347 NSUN5 55695 213773_x_at 0.7123 0.0001
GSE23400 NSUN5 55695 203802_x_at 0.3185 0.0000
GSE26886 NSUN5 55695 213773_x_at 0.6810 0.0000
GSE29001 NSUN5 55695 213773_x_at 0.5735 0.0512
GSE38129 NSUN5 55695 213773_x_at 0.6511 0.0000
GSE45670 NSUN5 55695 213773_x_at 0.4732 0.0027
GSE53622 NSUN5 55695 132199 0.6392 0.0000
GSE53624 NSUN5 55695 132199 0.7563 0.0000
GSE63941 NSUN5 55695 213773_x_at 0.8368 0.0532
GSE77861 NSUN5 55695 213773_x_at 0.4615 0.0043
GSE97050 NSUN5 55695 A_23_P82412 0.4821 0.1816
SRP007169 NSUN5 55695 RNAseq 0.5261 0.2489
SRP008496 NSUN5 55695 RNAseq 0.9099 0.0012
SRP064894 NSUN5 55695 RNAseq 1.1102 0.0001
SRP133303 NSUN5 55695 RNAseq 0.7121 0.0011
SRP159526 NSUN5 55695 RNAseq 0.6104 0.0020
SRP193095 NSUN5 55695 RNAseq 0.9688 0.0000
SRP219564 NSUN5 55695 RNAseq 1.1914 0.0089
TCGA NSUN5 55695 RNAseq 0.2811 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by NSUN5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NSUN5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NSUN5 55695 12 1 17
GSE20123 NSUN5 55695 11 1 18
GSE43470 NSUN5 55695 3 2 38
GSE46452 NSUN5 55695 12 0 47
GSE47630 NSUN5 55695 7 2 31
GSE54993 NSUN5 55695 2 7 61
GSE54994 NSUN5 55695 13 3 37
GSE60625 NSUN5 55695 0 0 11
GSE74703 NSUN5 55695 3 1 32
GSE74704 NSUN5 55695 7 1 12
TCGA NSUN5 55695 45 7 44

Total number of gains: 115; Total number of losses: 25; Total Number of normals: 348.  

 

Somatic mutations of NSUN5:

 

Generating mutation plots.

 

Highly correlated genes for NSUN5:

 

Showing top 20/1848 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NSUN5SRSF60.835284303
NSUN5TMTC40.810558303
NSUN5ZNF5670.80497303
NSUN5DYRK20.788086303
NSUN5ZNF2600.786544303
NSUN5ZNF6680.778973303
NSUN5ATP11C0.776104303
NSUN5RPAIN0.739947303
NSUN5NEK80.737481303
NSUN5WDR810.736603403
NSUN5EBNA1BP20.73483303
NSUN5EXOC60.724424403
NSUN5FAM89A0.723979303
NSUN5C1orf1150.723506303
NSUN5VPS13C0.723114403
NSUN5CDCA20.722269404
NSUN5SLC39A30.720611404
NSUN5ACBD60.720356606
NSUN5PET1170.718954303
NSUN5PTCD10.718324404

For details and further investigation, click here