| Full name: serine and arginine rich splicing factor 6 | Alias Symbol: SRP55|B52 | ||
| Type: protein-coding gene | Cytoband: 20q13.11 | ||
| Entrez ID: 6431 | HGNC ID: HGNC:10788 | Ensembl Gene: ENSG00000124193 | OMIM ID: 601944 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SRSF6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05168 | Herpes simplex infection |
Expression of SRSF6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRSF6 | 6431 | 208804_s_at | 0.2886 | 0.5375 | |
| GSE20347 | SRSF6 | 6431 | 208804_s_at | 0.2513 | 0.0804 | |
| GSE23400 | SRSF6 | 6431 | 208804_s_at | 0.2340 | 0.0007 | |
| GSE26886 | SRSF6 | 6431 | 208804_s_at | 0.1041 | 0.7782 | |
| GSE29001 | SRSF6 | 6431 | 208804_s_at | 0.2854 | 0.3430 | |
| GSE38129 | SRSF6 | 6431 | 208804_s_at | 0.1879 | 0.2112 | |
| GSE45670 | SRSF6 | 6431 | 208804_s_at | -0.1169 | 0.5345 | |
| GSE53622 | SRSF6 | 6431 | 26218 | -0.0267 | 0.7367 | |
| GSE53624 | SRSF6 | 6431 | 26218 | -0.1036 | 0.0753 | |
| GSE63941 | SRSF6 | 6431 | 208804_s_at | 0.0670 | 0.8813 | |
| GSE77861 | SRSF6 | 6431 | 208804_s_at | 0.5878 | 0.0482 | |
| GSE97050 | SRSF6 | 6431 | A_33_P3220530 | -0.0310 | 0.9321 | |
| SRP007169 | SRSF6 | 6431 | RNAseq | 0.5723 | 0.1636 | |
| SRP008496 | SRSF6 | 6431 | RNAseq | 0.8588 | 0.0001 | |
| SRP064894 | SRSF6 | 6431 | RNAseq | 0.3555 | 0.0457 | |
| SRP133303 | SRSF6 | 6431 | RNAseq | 0.3164 | 0.0346 | |
| SRP159526 | SRSF6 | 6431 | RNAseq | 0.1641 | 0.5713 | |
| SRP193095 | SRSF6 | 6431 | RNAseq | -0.0418 | 0.5509 | |
| SRP219564 | SRSF6 | 6431 | RNAseq | 0.5621 | 0.1800 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SRSF6 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SRSF6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRSF6 | 6431 | 13 | 1 | 16 | |
| GSE20123 | SRSF6 | 6431 | 13 | 1 | 16 | |
| GSE43470 | SRSF6 | 6431 | 12 | 1 | 30 | |
| GSE46452 | SRSF6 | 6431 | 29 | 0 | 30 | |
| GSE47630 | SRSF6 | 6431 | 24 | 0 | 16 | |
| GSE54993 | SRSF6 | 6431 | 0 | 17 | 53 | |
| GSE54994 | SRSF6 | 6431 | 25 | 0 | 28 | |
| GSE60625 | SRSF6 | 6431 | 0 | 0 | 11 | |
| GSE74703 | SRSF6 | 6431 | 10 | 1 | 25 | |
| GSE74704 | SRSF6 | 6431 | 9 | 0 | 11 | |
| TCGA | SRSF6 | 6431 | 47 | 2 | 47 |
Total number of gains: 182; Total number of losses: 23; Total Number of normals: 283.
Somatic mutations of SRSF6:
Generating mutation plots.
Highly correlated genes for SRSF6:
Showing top 20/657 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRSF6 | ZBTB2 | 0.881033 | 3 | 0 | 3 |
| SRSF6 | FAM98B | 0.859991 | 3 | 0 | 3 |
| SRSF6 | MRPL18 | 0.856591 | 3 | 0 | 3 |
| SRSF6 | ZNF766 | 0.851859 | 3 | 0 | 3 |
| SRSF6 | NSUN5 | 0.835284 | 3 | 0 | 3 |
| SRSF6 | SLC25A33 | 0.83067 | 3 | 0 | 3 |
| SRSF6 | ZXDA | 0.812844 | 3 | 0 | 3 |
| SRSF6 | PIF1 | 0.809557 | 3 | 0 | 3 |
| SRSF6 | TWISTNB | 0.802113 | 3 | 0 | 3 |
| SRSF6 | ANKIB1 | 0.796813 | 3 | 0 | 3 |
| SRSF6 | METAP1D | 0.78864 | 3 | 0 | 3 |
| SRSF6 | B3GALNT2 | 0.786974 | 3 | 0 | 3 |
| SRSF6 | ZNF567 | 0.785264 | 3 | 0 | 3 |
| SRSF6 | MED1 | 0.781503 | 3 | 0 | 3 |
| SRSF6 | ZNF317 | 0.781298 | 4 | 0 | 4 |
| SRSF6 | ATIC | 0.780646 | 3 | 0 | 3 |
| SRSF6 | ZCCHC3 | 0.779055 | 3 | 0 | 3 |
| SRSF6 | ZNF418 | 0.778423 | 3 | 0 | 3 |
| SRSF6 | CEP95 | 0.776028 | 3 | 0 | 3 |
| SRSF6 | GNPTAB | 0.77556 | 3 | 0 | 3 |
For details and further investigation, click here
