CDCA2

 

Full name: cell division cycle associated 2 Alias Symbol: Repo-Man|PPP1R81
Type: protein-coding gene Cytoband: 8p21.2
Entrez ID: 157313 HGNC ID: HGNC:14623 Ensembl Gene: ENSG00000184661 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CDCA2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDCA2 157313 226661_at 1.7074 0.0164
GSE26886 CDCA2 157313 226661_at 0.8912 0.0258
GSE45670 CDCA2 157313 226661_at 1.4807 0.0000
GSE63941 CDCA2 157313 226661_at 2.3393 0.0022
GSE77861 CDCA2 157313 226661_at 1.2217 0.0016
GSE97050 CDCA2 157313 A_23_P385861 1.0543 0.0849
SRP007169 CDCA2 157313 RNAseq 2.8933 0.0000
SRP008496 CDCA2 157313 RNAseq 2.1389 0.0000
SRP064894 CDCA2 157313 RNAseq 1.7352 0.0000
SRP133303 CDCA2 157313 RNAseq 1.3312 0.0001
SRP159526 CDCA2 157313 RNAseq 1.4265 0.0013
SRP193095 CDCA2 157313 RNAseq 1.0098 0.0000
SRP219564 CDCA2 157313 RNAseq 1.2557 0.0896
TCGA CDCA2 157313 RNAseq 1.4097 0.0000

Upregulated datasets: 11; Downregulated datasets: 0.  

 

Survival by CDCA2 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of CDCA2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDCA2 157313 4 12 14
GSE20123 CDCA2 157313 4 12 14
GSE43470 CDCA2 157313 4 7 32
GSE46452 CDCA2 157313 13 13 33
GSE47630 CDCA2 157313 10 8 22
GSE54993 CDCA2 157313 2 15 53
GSE54994 CDCA2 157313 9 16 28
GSE60625 CDCA2 157313 3 0 8
GSE74703 CDCA2 157313 4 6 26
GSE74704 CDCA2 157313 3 8 9
TCGA CDCA2 157313 15 44 37

Total number of gains: 71; Total number of losses: 141; Total Number of normals: 276.  

 

Somatic mutations of CDCA2:

 

Generating mutation plots.

 

Highly correlated genes for CDCA2:

 

Showing top 20/1748 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDCA2HJURP0.907859606
CDCA2GTF2E10.880757303
CDCA2NUSAP10.851787606
CDCA2NCAPH0.845739505
CDCA2MTFR20.845723505
CDCA2PBK0.842953707
CDCA2BORA0.842081606
CDCA2DEPDC1B0.840659505
CDCA2PNO10.838574303
CDCA2CENPF0.835571606
CDCA2GINS10.834054606
CDCA2EIF3B0.8335303
CDCA2TTL0.830485404
CDCA2TRAF30.829828404
CDCA2BUB10.82854707
CDCA2UBE2C0.828211706
CDCA2BIRC50.827863606
CDCA2AURKA0.826493706
CDCA2RRP90.82484303
CDCA2KIF18B0.823043505

For details and further investigation, click here