| Full name: NIMA related kinase 8 | Alias Symbol: NPHP9 | ||
| Type: protein-coding gene | Cytoband: 17q11.2 | ||
| Entrez ID: 284086 | HGNC ID: HGNC:13387 | Ensembl Gene: ENSG00000160602 | OMIM ID: 609799 |
| Drug and gene relationship at DGIdb | |||
Expression of NEK8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NEK8 | 284086 | 1557172_x_at | 0.0974 | 0.8182 | |
| GSE26886 | NEK8 | 284086 | 1557172_x_at | 0.7423 | 0.0000 | |
| GSE45670 | NEK8 | 284086 | 1557172_x_at | 0.1850 | 0.2045 | |
| GSE63941 | NEK8 | 284086 | 1557172_x_at | -0.1033 | 0.7227 | |
| GSE77861 | NEK8 | 284086 | 1557172_x_at | 0.2406 | 0.2034 | |
| GSE97050 | NEK8 | 284086 | A_24_P99639 | 0.3172 | 0.2102 | |
| SRP007169 | NEK8 | 284086 | RNAseq | 0.9127 | 0.1508 | |
| SRP064894 | NEK8 | 284086 | RNAseq | 0.6117 | 0.0007 | |
| SRP133303 | NEK8 | 284086 | RNAseq | -0.1821 | 0.2139 | |
| SRP159526 | NEK8 | 284086 | RNAseq | 0.0292 | 0.9392 | |
| SRP193095 | NEK8 | 284086 | RNAseq | -0.1092 | 0.5185 | |
| SRP219564 | NEK8 | 284086 | RNAseq | 0.2593 | 0.5686 | |
| TCGA | NEK8 | 284086 | RNAseq | 0.0622 | 0.5480 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NEK8 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of NEK8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NEK8 | 284086 | 9 | 1 | 20 | |
| GSE20123 | NEK8 | 284086 | 9 | 1 | 20 | |
| GSE43470 | NEK8 | 284086 | 0 | 1 | 42 | |
| GSE46452 | NEK8 | 284086 | 33 | 1 | 25 | |
| GSE47630 | NEK8 | 284086 | 7 | 1 | 32 | |
| GSE54993 | NEK8 | 284086 | 2 | 3 | 65 | |
| GSE54994 | NEK8 | 284086 | 7 | 6 | 40 | |
| GSE60625 | NEK8 | 284086 | 4 | 0 | 7 | |
| GSE74703 | NEK8 | 284086 | 0 | 1 | 35 | |
| GSE74704 | NEK8 | 284086 | 7 | 1 | 12 | |
| TCGA | NEK8 | 284086 | 21 | 10 | 65 |
Total number of gains: 99; Total number of losses: 26; Total Number of normals: 363.
Somatic mutations of NEK8:
Generating mutation plots.
Highly correlated genes for NEK8:
Showing top 20/361 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NEK8 | AP1G2 | 0.777789 | 3 | 0 | 3 |
| NEK8 | OLA1 | 0.769863 | 3 | 0 | 3 |
| NEK8 | AKAP8L | 0.749178 | 3 | 0 | 3 |
| NEK8 | SMCR5 | 0.738393 | 3 | 0 | 3 |
| NEK8 | UTP23 | 0.738277 | 3 | 0 | 3 |
| NEK8 | NSUN5 | 0.737481 | 3 | 0 | 3 |
| NEK8 | MZT2B | 0.736624 | 5 | 0 | 5 |
| NEK8 | FIP1L1 | 0.734234 | 3 | 0 | 3 |
| NEK8 | FASTKD1 | 0.729265 | 3 | 0 | 3 |
| NEK8 | LARP6 | 0.728735 | 3 | 0 | 3 |
| NEK8 | RP9 | 0.72772 | 3 | 0 | 3 |
| NEK8 | SIGLEC15 | 0.725583 | 3 | 0 | 3 |
| NEK8 | ALKBH6 | 0.725114 | 4 | 0 | 4 |
| NEK8 | DDX59 | 0.724732 | 5 | 0 | 4 |
| NEK8 | HAUS2 | 0.72467 | 5 | 0 | 4 |
| NEK8 | CTBP2 | 0.72175 | 3 | 0 | 3 |
| NEK8 | DLGAP4 | 0.721602 | 4 | 0 | 3 |
| NEK8 | GPX8 | 0.719004 | 3 | 0 | 3 |
| NEK8 | ORC2 | 0.714408 | 3 | 0 | 3 |
| NEK8 | ZNF611 | 0.713123 | 3 | 0 | 3 |
For details and further investigation, click here
