| Full name: otoferlin | Alias Symbol: FER1L2|DFNB6 | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 9381 | HGNC ID: HGNC:8515 | Ensembl Gene: ENSG00000115155 | OMIM ID: 603681 |
| Drug and gene relationship at DGIdb | |||
Expression of OTOF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OTOF | 9381 | 1555251_a_at | -0.0443 | 0.8657 | |
| GSE20347 | OTOF | 9381 | 220492_s_at | 0.0384 | 0.7018 | |
| GSE23400 | OTOF | 9381 | 220492_s_at | -0.0671 | 0.0208 | |
| GSE26886 | OTOF | 9381 | 1555251_a_at | 0.1292 | 0.1030 | |
| GSE29001 | OTOF | 9381 | 220492_s_at | -0.1349 | 0.1309 | |
| GSE38129 | OTOF | 9381 | 220492_s_at | -0.0763 | 0.2726 | |
| GSE45670 | OTOF | 9381 | 1555251_a_at | 0.1868 | 0.0296 | |
| GSE53622 | OTOF | 9381 | 110403 | -1.8497 | 0.0000 | |
| GSE53624 | OTOF | 9381 | 110403 | -2.9068 | 0.0000 | |
| GSE63941 | OTOF | 9381 | 1555251_a_at | 0.0436 | 0.6795 | |
| GSE77861 | OTOF | 9381 | 220492_s_at | -0.0392 | 0.7608 | |
| GSE97050 | OTOF | 9381 | A_23_P254852 | -0.6076 | 0.2372 | |
| SRP219564 | OTOF | 9381 | RNAseq | 2.4913 | 0.0022 | |
| TCGA | OTOF | 9381 | RNAseq | -0.4255 | 0.4203 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by OTOF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OTOF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OTOF | 9381 | 11 | 2 | 17 | |
| GSE20123 | OTOF | 9381 | 11 | 2 | 17 | |
| GSE43470 | OTOF | 9381 | 3 | 1 | 39 | |
| GSE46452 | OTOF | 9381 | 3 | 4 | 52 | |
| GSE47630 | OTOF | 9381 | 8 | 0 | 32 | |
| GSE54993 | OTOF | 9381 | 0 | 6 | 64 | |
| GSE54994 | OTOF | 9381 | 10 | 0 | 43 | |
| GSE60625 | OTOF | 9381 | 0 | 3 | 8 | |
| GSE74703 | OTOF | 9381 | 3 | 0 | 33 | |
| GSE74704 | OTOF | 9381 | 9 | 1 | 10 | |
| TCGA | OTOF | 9381 | 37 | 2 | 57 |
Total number of gains: 95; Total number of losses: 21; Total Number of normals: 372.
Somatic mutations of OTOF:
Generating mutation plots.
Highly correlated genes for OTOF:
Showing top 20/753 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OTOF | CSTL1 | 0.904913 | 3 | 0 | 3 |
| OTOF | FAM163B | 0.898487 | 3 | 0 | 3 |
| OTOF | OR2Z1 | 0.898441 | 3 | 0 | 3 |
| OTOF | KRTAP20-1 | 0.893061 | 3 | 0 | 3 |
| OTOF | OR10G8 | 0.844783 | 3 | 0 | 3 |
| OTOF | BARHL2 | 0.835529 | 3 | 0 | 3 |
| OTOF | GATA4 | 0.809305 | 3 | 0 | 3 |
| OTOF | MUC22 | 0.796868 | 3 | 0 | 3 |
| OTOF | ARID5A | 0.795976 | 4 | 0 | 4 |
| OTOF | MFSD2B | 0.789443 | 4 | 0 | 4 |
| OTOF | OR10G3 | 0.788913 | 3 | 0 | 3 |
| OTOF | NCCRP1 | 0.788385 | 3 | 0 | 3 |
| OTOF | TEN1 | 0.785642 | 3 | 0 | 3 |
| OTOF | KPRP | 0.784728 | 3 | 0 | 3 |
| OTOF | MORN3 | 0.779285 | 4 | 0 | 4 |
| OTOF | OTOP3 | 0.77754 | 3 | 0 | 3 |
| OTOF | FAM71E2 | 0.767679 | 3 | 0 | 3 |
| OTOF | GPX6 | 0.767081 | 3 | 0 | 3 |
| OTOF | CD164L2 | 0.76436 | 3 | 0 | 3 |
| OTOF | CLDN24 | 0.759687 | 3 | 0 | 3 |
For details and further investigation, click here
