| Full name: glutathione peroxidase 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p22.1 | ||
| Entrez ID: 257202 | HGNC ID: HGNC:4558 | Ensembl Gene: ENSG00000198704 | OMIM ID: 607913 |
| Drug and gene relationship at DGIdb | |||
Expression of GPX6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | GPX6 | 257202 | 18318 | -2.7766 | 0.0000 | |
| GSE53624 | GPX6 | 257202 | 18318 | -2.3613 | 0.0000 | |
| GSE97050 | GPX6 | 257202 | A_33_P3418414 | -0.3982 | 0.1972 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by GPX6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPX6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPX6 | 257202 | 3 | 2 | 25 | |
| GSE20123 | GPX6 | 257202 | 3 | 2 | 25 | |
| GSE43470 | GPX6 | 257202 | 5 | 0 | 38 | |
| GSE46452 | GPX6 | 257202 | 1 | 10 | 48 | |
| GSE47630 | GPX6 | 257202 | 7 | 4 | 29 | |
| GSE54993 | GPX6 | 257202 | 2 | 1 | 67 | |
| GSE54994 | GPX6 | 257202 | 11 | 4 | 38 | |
| GSE60625 | GPX6 | 257202 | 0 | 1 | 10 | |
| GSE74703 | GPX6 | 257202 | 5 | 0 | 31 | |
| GSE74704 | GPX6 | 257202 | 0 | 1 | 19 | |
| TCGA | GPX6 | 257202 | 16 | 19 | 61 |
Total number of gains: 53; Total number of losses: 44; Total Number of normals: 391.
Somatic mutations of GPX6:
Generating mutation plots.
Highly correlated genes for GPX6:
Showing top 20/257 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPX6 | ARID5A | 0.843779 | 3 | 0 | 3 |
| GPX6 | ELN | 0.819692 | 3 | 0 | 3 |
| GPX6 | MAL | 0.808843 | 3 | 0 | 3 |
| GPX6 | KRT4 | 0.803553 | 3 | 0 | 3 |
| GPX6 | RAET1E | 0.795761 | 3 | 0 | 3 |
| GPX6 | VSIG10L | 0.794665 | 3 | 0 | 3 |
| GPX6 | SPINK7 | 0.794132 | 3 | 0 | 3 |
| GPX6 | DEGS2 | 0.792679 | 3 | 0 | 3 |
| GPX6 | SLURP1 | 0.791968 | 3 | 0 | 3 |
| GPX6 | NCR1 | 0.79024 | 3 | 0 | 3 |
| GPX6 | NANOS2 | 0.785551 | 3 | 0 | 3 |
| GPX6 | SPRR3 | 0.784734 | 3 | 0 | 3 |
| GPX6 | IQCF1 | 0.782673 | 3 | 0 | 3 |
| GPX6 | SCNN1B | 0.780784 | 3 | 0 | 3 |
| GPX6 | BLVRB | 0.777486 | 3 | 0 | 3 |
| GPX6 | CCDC50 | 0.777117 | 3 | 0 | 3 |
| GPX6 | FAM163B | 0.776735 | 3 | 0 | 3 |
| GPX6 | KRTAP20-1 | 0.775829 | 3 | 0 | 3 |
| GPX6 | ACER1 | 0.775031 | 3 | 0 | 3 |
| GPX6 | EPHX2 | 0.773882 | 3 | 0 | 3 |
For details and further investigation, click here
