| Full name: GATA binding protein 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8p23.1 | ||
| Entrez ID: 2626 | HGNC ID: HGNC:4173 | Ensembl Gene: ENSG00000136574 | OMIM ID: 600576 |
| Drug and gene relationship at DGIdb | |||
GATA4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway | |
| hsa04919 | Thyroid hormone signaling pathway |
Expression of GATA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GATA4 | 2626 | 230855_at | 0.0551 | 0.8872 | |
| GSE20347 | GATA4 | 2626 | 205517_at | 0.0395 | 0.6801 | |
| GSE23400 | GATA4 | 2626 | 205517_at | -0.0629 | 0.0650 | |
| GSE26886 | GATA4 | 2626 | 230855_at | 0.2172 | 0.2521 | |
| GSE29001 | GATA4 | 2626 | 205517_at | 0.0846 | 0.5938 | |
| GSE38129 | GATA4 | 2626 | 205517_at | -0.2327 | 0.2934 | |
| GSE45670 | GATA4 | 2626 | 1553131_a_at | 0.0113 | 0.9179 | |
| GSE53622 | GATA4 | 2626 | 26456 | -0.4181 | 0.0044 | |
| GSE53624 | GATA4 | 2626 | 145642 | -3.8622 | 0.0000 | |
| GSE63941 | GATA4 | 2626 | 230855_at | -0.1160 | 0.5902 | |
| GSE77861 | GATA4 | 2626 | 230855_at | -0.1250 | 0.4724 | |
| GSE97050 | GATA4 | 2626 | A_33_P3360363 | -0.3103 | 0.2359 | |
| SRP159526 | GATA4 | 2626 | RNAseq | 7.3929 | 0.0000 | |
| TCGA | GATA4 | 2626 | RNAseq | -2.0637 | 0.0007 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by GATA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GATA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GATA4 | 2626 | 4 | 11 | 15 | |
| GSE20123 | GATA4 | 2626 | 4 | 11 | 15 | |
| GSE43470 | GATA4 | 2626 | 4 | 9 | 30 | |
| GSE46452 | GATA4 | 2626 | 12 | 14 | 33 | |
| GSE47630 | GATA4 | 2626 | 10 | 7 | 23 | |
| GSE54993 | GATA4 | 2626 | 3 | 14 | 53 | |
| GSE54994 | GATA4 | 2626 | 8 | 19 | 26 | |
| GSE60625 | GATA4 | 2626 | 3 | 0 | 8 | |
| GSE74703 | GATA4 | 2626 | 4 | 7 | 25 | |
| GSE74704 | GATA4 | 2626 | 3 | 7 | 10 | |
| TCGA | GATA4 | 2626 | 14 | 39 | 43 |
Total number of gains: 69; Total number of losses: 138; Total Number of normals: 281.
Somatic mutations of GATA4:
Generating mutation plots.
Highly correlated genes for GATA4:
Showing top 20/311 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GATA4 | OTOF | 0.809305 | 3 | 0 | 3 |
| GATA4 | KLHL10 | 0.787015 | 3 | 0 | 3 |
| GATA4 | KRTAP6-3 | 0.744665 | 3 | 0 | 3 |
| GATA4 | DEGS2 | 0.737354 | 3 | 0 | 3 |
| GATA4 | SPINK7 | 0.730755 | 3 | 0 | 3 |
| GATA4 | TJP2 | 0.729693 | 3 | 0 | 3 |
| GATA4 | GAB2 | 0.723599 | 3 | 0 | 3 |
| GATA4 | CHRNA10 | 0.721812 | 3 | 0 | 3 |
| GATA4 | AMER3 | 0.712612 | 3 | 0 | 3 |
| GATA4 | BTBD19 | 0.711426 | 4 | 0 | 4 |
| GATA4 | ITGB1BP2 | 0.7107 | 3 | 0 | 3 |
| GATA4 | GRIK4 | 0.692835 | 3 | 0 | 3 |
| GATA4 | PRSS27 | 0.690552 | 3 | 0 | 3 |
| GATA4 | HMGB4 | 0.689757 | 4 | 0 | 4 |
| GATA4 | RNF123 | 0.684814 | 3 | 0 | 3 |
| GATA4 | ASPG | 0.683101 | 3 | 0 | 3 |
| GATA4 | PCDH1 | 0.681703 | 3 | 0 | 3 |
| GATA4 | ENDOV | 0.680488 | 4 | 0 | 4 |
| GATA4 | LACRT | 0.68042 | 3 | 0 | 3 |
| GATA4 | AVPR2 | 0.677139 | 4 | 0 | 4 |
For details and further investigation, click here
