PDGFA

 

Full name: platelet derived growth factor subunit A Alias Symbol: PDGF1|PDGF-A
Type: protein-coding gene Cytoband: 7p22.3
Entrez ID: 5154 HGNC ID: HGNC:8799 Ensembl Gene: ENSG00000197461 OMIM ID: 173430
Drug and gene relationship at DGIdb

 

PDGFA involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa04540Gap junction
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05231Choline metabolism in cancer

 

Expression of PDGFA:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PDGFA 5154 205463_s_at 0.4373 0.6846
GSE20347 PDGFA 5154 205463_s_at 1.1584 0.0001
GSE23400 PDGFA 5154 205463_s_at 0.7122 0.0000
GSE26886 PDGFA 5154 205463_s_at 2.0234 0.0000
GSE29001 PDGFA 5154 205463_s_at 1.2212 0.0001
GSE38129 PDGFA 5154 205463_s_at 0.9767 0.0026
GSE45670 PDGFA 5154 205463_s_at 0.4817 0.2571
GSE53622 PDGFA 5154 24767 0.9099 0.0000
GSE53624 PDGFA 5154 24767 0.5597 0.0000
GSE63941 PDGFA 5154 205463_s_at 3.3124 0.0000
GSE77861 PDGFA 5154 205463_s_at 1.2850 0.0169
GSE97050 PDGFA 5154 A_33_P3372666 0.2902 0.2389
SRP007169 PDGFA 5154 RNAseq 3.4716 0.0000
SRP008496 PDGFA 5154 RNAseq 3.8337 0.0000
SRP064894 PDGFA 5154 RNAseq 0.9439 0.0000
SRP133303 PDGFA 5154 RNAseq 0.8734 0.0000
SRP193095 PDGFA 5154 RNAseq 1.1119 0.0000
SRP219564 PDGFA 5154 RNAseq 0.3803 0.5335
TCGA PDGFA 5154 RNAseq -0.0913 0.4617

Upregulated datasets: 8; Downregulated datasets: 0.  

 

Survival by PDGFA expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PDGFA:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PDGFA 5154 14 0 16
GSE20123 PDGFA 5154 14 0 16
GSE43470 PDGFA 5154 6 2 35
GSE46452 PDGFA 5154 13 1 45
GSE47630 PDGFA 5154 12 1 27
GSE54993 PDGFA 5154 3 10 57
GSE54994 PDGFA 5154 20 3 30
GSE60625 PDGFA 5154 0 0 11
GSE74703 PDGFA 5154 6 1 29
GSE74704 PDGFA 5154 9 0 11
TCGA PDGFA 5154 56 6 34

Total number of gains: 153; Total number of losses: 24; Total Number of normals: 311.  

 

Somatic mutations of PDGFA:

 

Generating mutation plots.

 

Highly correlated genes for PDGFA:

 

Showing top 20/965 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PDGFACPT1A0.760318303
PDGFARILPL10.754625303
PDGFAPMEPA10.72873511010
PDGFACHST150.7207511109
PDGFAADAMTS150.717944303
PDGFAKRTCAP20.715093303
PDGFAANKRD520.714261303
PDGFAPLOD30.713631009
PDGFAFKBP90.70997510010
PDGFAPXYLP10.709014303
PDGFASLC39A140.7081471009
PDGFAFNDC3B0.70177510010
PDGFAOBSL10.701464605
PDGFASERPINH10.69616611010
PDGFALPCAT10.687631008
PDGFACHSY10.6869051009
PDGFASLC41A10.685592403
PDGFALSG10.681145404
PDGFAHIP10.679857707
PDGFAICE10.678156808

For details and further investigation, click here