| Full name: huntingtin interacting protein 1 | Alias Symbol: ILWEQ | ||
| Type: protein-coding gene | Cytoband: 7q11.23 | ||
| Entrez ID: 3092 | HGNC ID: HGNC:4913 | Ensembl Gene: ENSG00000127946 | OMIM ID: 601767 |
| Drug and gene relationship at DGIdb | |||
HIP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05016 | Huntington's disease |
Expression of HIP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HIP1 | 3092 | 226364_at | 0.5396 | 0.2781 | |
| GSE20347 | HIP1 | 3092 | 205425_at | 0.6402 | 0.0089 | |
| GSE23400 | HIP1 | 3092 | 205426_s_at | 0.0960 | 0.0270 | |
| GSE26886 | HIP1 | 3092 | 226364_at | 1.9236 | 0.0000 | |
| GSE29001 | HIP1 | 3092 | 205426_s_at | -0.0261 | 0.8815 | |
| GSE38129 | HIP1 | 3092 | 205425_at | 0.6642 | 0.0368 | |
| GSE45670 | HIP1 | 3092 | 226364_at | 0.3572 | 0.4000 | |
| GSE53622 | HIP1 | 3092 | 12781 | 0.6509 | 0.0000 | |
| GSE53624 | HIP1 | 3092 | 12781 | 0.9344 | 0.0000 | |
| GSE63941 | HIP1 | 3092 | 226364_at | -0.5887 | 0.5361 | |
| GSE77861 | HIP1 | 3092 | 226364_at | 1.0488 | 0.0193 | |
| GSE97050 | HIP1 | 3092 | A_24_P363548 | 0.2298 | 0.4376 | |
| SRP007169 | HIP1 | 3092 | RNAseq | 2.8333 | 0.0000 | |
| SRP008496 | HIP1 | 3092 | RNAseq | 2.5377 | 0.0000 | |
| SRP064894 | HIP1 | 3092 | RNAseq | 0.9325 | 0.0000 | |
| SRP133303 | HIP1 | 3092 | RNAseq | 0.7799 | 0.0000 | |
| SRP159526 | HIP1 | 3092 | RNAseq | 0.9578 | 0.0004 | |
| SRP193095 | HIP1 | 3092 | RNAseq | 1.4333 | 0.0000 | |
| SRP219564 | HIP1 | 3092 | RNAseq | 0.2961 | 0.5603 | |
| TCGA | HIP1 | 3092 | RNAseq | 0.1558 | 0.0950 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by HIP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HIP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HIP1 | 3092 | 14 | 1 | 15 | |
| GSE20123 | HIP1 | 3092 | 14 | 1 | 15 | |
| GSE43470 | HIP1 | 3092 | 3 | 2 | 38 | |
| GSE46452 | HIP1 | 3092 | 12 | 0 | 47 | |
| GSE47630 | HIP1 | 3092 | 7 | 2 | 31 | |
| GSE54993 | HIP1 | 3092 | 2 | 7 | 61 | |
| GSE54994 | HIP1 | 3092 | 14 | 3 | 36 | |
| GSE60625 | HIP1 | 3092 | 0 | 0 | 11 | |
| GSE74703 | HIP1 | 3092 | 3 | 1 | 32 | |
| GSE74704 | HIP1 | 3092 | 8 | 1 | 11 | |
| TCGA | HIP1 | 3092 | 45 | 6 | 45 |
Total number of gains: 122; Total number of losses: 24; Total Number of normals: 342.
Somatic mutations of HIP1:
Generating mutation plots.
Highly correlated genes for HIP1:
Showing top 20/1618 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HIP1 | DOCK11 | 0.830829 | 4 | 0 | 4 |
| HIP1 | RAB34 | 0.826528 | 3 | 0 | 3 |
| HIP1 | PKIG | 0.782771 | 4 | 0 | 4 |
| HIP1 | SSBP4 | 0.779751 | 4 | 0 | 4 |
| HIP1 | NF1 | 0.772402 | 3 | 0 | 3 |
| HIP1 | GHDC | 0.763564 | 4 | 0 | 4 |
| HIP1 | LETM2 | 0.762726 | 3 | 0 | 3 |
| HIP1 | SF3A2 | 0.76121 | 4 | 0 | 4 |
| HIP1 | MBD3 | 0.75491 | 3 | 0 | 3 |
| HIP1 | POGZ | 0.750865 | 3 | 0 | 3 |
| HIP1 | RUNDC1 | 0.746888 | 3 | 0 | 3 |
| HIP1 | DGKH | 0.746518 | 4 | 0 | 4 |
| HIP1 | WDR54 | 0.745404 | 7 | 0 | 7 |
| HIP1 | NACC1 | 0.740559 | 3 | 0 | 3 |
| HIP1 | KCTD13 | 0.739233 | 3 | 0 | 3 |
| HIP1 | TIGD1 | 0.73762 | 3 | 0 | 3 |
| HIP1 | SEC61G | 0.733923 | 3 | 0 | 3 |
| HIP1 | SLC38A10 | 0.726357 | 6 | 0 | 5 |
| HIP1 | BAZ1B | 0.724654 | 8 | 0 | 8 |
| HIP1 | SORBS3 | 0.723438 | 4 | 0 | 4 |
For details and further investigation, click here
