| Full name: ADAM metallopeptidase with thrombospondin type 1 motif 15 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q24.3 | ||
| Entrez ID: 170689 | HGNC ID: HGNC:16305 | Ensembl Gene: ENSG00000166106 | OMIM ID: 607509 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAMTS15:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAMTS15 | 170689 | 229004_at | -0.2676 | 0.7490 | |
| GSE26886 | ADAMTS15 | 170689 | 1553427_at | 0.0159 | 0.9097 | |
| GSE45670 | ADAMTS15 | 170689 | 229004_at | 0.2048 | 0.6852 | |
| GSE53622 | ADAMTS15 | 170689 | 39890 | -0.6034 | 0.0036 | |
| GSE53624 | ADAMTS15 | 170689 | 39890 | -0.1987 | 0.0942 | |
| GSE63941 | ADAMTS15 | 170689 | 229004_at | -0.4827 | 0.5877 | |
| GSE77861 | ADAMTS15 | 170689 | 229004_at | 0.3486 | 0.1120 | |
| GSE97050 | ADAMTS15 | 170689 | A_33_P3316790 | -0.0062 | 0.9845 | |
| SRP007169 | ADAMTS15 | 170689 | RNAseq | 4.7275 | 0.0000 | |
| SRP064894 | ADAMTS15 | 170689 | RNAseq | 0.4044 | 0.3519 | |
| SRP133303 | ADAMTS15 | 170689 | RNAseq | 0.4218 | 0.2833 | |
| SRP159526 | ADAMTS15 | 170689 | RNAseq | -0.6661 | 0.2132 | |
| SRP219564 | ADAMTS15 | 170689 | RNAseq | 0.8737 | 0.2917 | |
| TCGA | ADAMTS15 | 170689 | RNAseq | -0.7115 | 0.0180 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ADAMTS15 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAMTS15:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAMTS15 | 170689 | 0 | 13 | 17 | |
| GSE20123 | ADAMTS15 | 170689 | 0 | 13 | 17 | |
| GSE43470 | ADAMTS15 | 170689 | 2 | 7 | 34 | |
| GSE46452 | ADAMTS15 | 170689 | 3 | 26 | 30 | |
| GSE47630 | ADAMTS15 | 170689 | 2 | 19 | 19 | |
| GSE54993 | ADAMTS15 | 170689 | 10 | 0 | 60 | |
| GSE54994 | ADAMTS15 | 170689 | 5 | 19 | 29 | |
| GSE60625 | ADAMTS15 | 170689 | 0 | 3 | 8 | |
| GSE74703 | ADAMTS15 | 170689 | 1 | 5 | 30 | |
| GSE74704 | ADAMTS15 | 170689 | 0 | 9 | 11 | |
| TCGA | ADAMTS15 | 170689 | 5 | 50 | 41 |
Total number of gains: 28; Total number of losses: 164; Total Number of normals: 296.
Somatic mutations of ADAMTS15:
Generating mutation plots.
Highly correlated genes for ADAMTS15:
Showing top 20/253 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAMTS15 | PPP1R18 | 0.747399 | 3 | 0 | 3 |
| ADAMTS15 | PLAUR | 0.74235 | 3 | 0 | 3 |
| ADAMTS15 | PDGFA | 0.717944 | 3 | 0 | 3 |
| ADAMTS15 | INHBA | 0.713103 | 3 | 0 | 3 |
| ADAMTS15 | FSTL1 | 0.709356 | 4 | 0 | 4 |
| ADAMTS15 | LTBP1 | 0.701687 | 4 | 0 | 4 |
| ADAMTS15 | EGR2 | 0.701 | 3 | 0 | 3 |
| ADAMTS15 | PXN | 0.70024 | 3 | 0 | 3 |
| ADAMTS15 | CHST15 | 0.699018 | 4 | 0 | 4 |
| ADAMTS15 | SFXN3 | 0.694507 | 3 | 0 | 3 |
| ADAMTS15 | TWIST1 | 0.692127 | 3 | 0 | 3 |
| ADAMTS15 | TNFAIP6 | 0.6917 | 3 | 0 | 3 |
| ADAMTS15 | LGALS1 | 0.688328 | 4 | 0 | 4 |
| ADAMTS15 | ANXA5 | 0.68176 | 4 | 0 | 4 |
| ADAMTS15 | THBS1 | 0.677533 | 3 | 0 | 3 |
| ADAMTS15 | TPBG | 0.676012 | 4 | 0 | 4 |
| ADAMTS15 | ANO6 | 0.672146 | 4 | 0 | 4 |
| ADAMTS15 | MAN1A1 | 0.670935 | 4 | 0 | 3 |
| ADAMTS15 | PEAR1 | 0.669645 | 4 | 0 | 4 |
| ADAMTS15 | FGFR1 | 0.668273 | 3 | 0 | 3 |
For details and further investigation, click here
