PLOD3

 

Full name: procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 Alias Symbol: LH3
Type: protein-coding gene Cytoband: 7q22.1
Entrez ID: 8985 HGNC ID: HGNC:9083 Ensembl Gene: ENSG00000106397 OMIM ID: 603066
Drug and gene relationship at DGIdb

 

Expression of PLOD3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PLOD3 8985 202185_at 1.1850 0.0831
GSE20347 PLOD3 8985 202185_at 1.4213 0.0000
GSE23400 PLOD3 8985 202185_at 0.7060 0.0000
GSE26886 PLOD3 8985 202185_at 2.5460 0.0000
GSE29001 PLOD3 8985 202185_at 1.1414 0.0007
GSE38129 PLOD3 8985 202185_at 1.1787 0.0000
GSE45670 PLOD3 8985 202185_at 0.8075 0.0102
GSE53622 PLOD3 8985 45837 1.2684 0.0000
GSE53624 PLOD3 8985 45837 1.2784 0.0000
GSE63941 PLOD3 8985 202185_at -0.8024 0.1777
GSE77861 PLOD3 8985 202185_at 1.1325 0.0237
GSE97050 PLOD3 8985 A_23_P168788 0.2025 0.3054
SRP007169 PLOD3 8985 RNAseq 2.4057 0.0000
SRP008496 PLOD3 8985 RNAseq 3.0748 0.0000
SRP064894 PLOD3 8985 RNAseq 2.1182 0.0000
SRP133303 PLOD3 8985 RNAseq 1.8027 0.0000
SRP159526 PLOD3 8985 RNAseq 1.6767 0.0000
SRP193095 PLOD3 8985 RNAseq 2.1168 0.0000
SRP219564 PLOD3 8985 RNAseq 1.3366 0.0166
TCGA PLOD3 8985 RNAseq 0.2000 0.0197

Upregulated datasets: 14; Downregulated datasets: 0.  

 

Survival by PLOD3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PLOD3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PLOD3 8985 13 0 17
GSE20123 PLOD3 8985 13 0 17
GSE43470 PLOD3 8985 7 2 34
GSE46452 PLOD3 8985 11 1 47
GSE47630 PLOD3 8985 7 3 30
GSE54993 PLOD3 8985 1 10 59
GSE54994 PLOD3 8985 15 3 35
GSE60625 PLOD3 8985 0 0 11
GSE74703 PLOD3 8985 7 1 28
GSE74704 PLOD3 8985 9 0 11
TCGA PLOD3 8985 53 6 37

Total number of gains: 136; Total number of losses: 26; Total Number of normals: 326.  

 

Somatic mutations of PLOD3:

 

Generating mutation plots.

 

Highly correlated genes for PLOD3:

 

Showing top 20/2119 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PLOD3RILPL20.812226404
PLOD3L3MBTL30.783759303
PLOD3LPCAT10.78103111011
PLOD3DYNC2H10.779489303
PLOD3FNDC3B0.77882111011
PLOD3SERPINH10.77850811010
PLOD3CALU0.7711911011
PLOD3PLOD10.76935613011
PLOD3ARPC1B0.76793611010
PLOD3PXDN0.76673411011
PLOD3COL4A10.76591412012
PLOD3LMO10.763089303
PLOD3RILPL10.760425403
PLOD3SLC39A30.759204404
PLOD3SP40.754053404
PLOD3CD2760.751746504
PLOD3PLAU0.75145811011
PLOD3PTGS20.74696303
PLOD3ALG110.746163303
PLOD3LGALS10.74449411011

For details and further investigation, click here