| Full name: chondroitin sulfate synthase 1 | Alias Symbol: KIAA0990|CSS1 | ||
| Type: protein-coding gene | Cytoband: 15q26.3 | ||
| Entrez ID: 22856 | HGNC ID: HGNC:17198 | Ensembl Gene: ENSG00000131873 | OMIM ID: 608183 |
| Drug and gene relationship at DGIdb | |||
Expression of CHSY1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHSY1 | 22856 | 203044_at | 0.3488 | 0.5273 | |
| GSE20347 | CHSY1 | 22856 | 203044_at | 0.6615 | 0.0014 | |
| GSE23400 | CHSY1 | 22856 | 203044_at | 1.1133 | 0.0000 | |
| GSE26886 | CHSY1 | 22856 | 203044_at | 1.2869 | 0.0000 | |
| GSE29001 | CHSY1 | 22856 | 203044_at | 1.1447 | 0.0017 | |
| GSE38129 | CHSY1 | 22856 | 203044_at | 0.7669 | 0.0000 | |
| GSE45670 | CHSY1 | 22856 | 203044_at | 0.1777 | 0.4806 | |
| GSE53622 | CHSY1 | 22856 | 136537 | 0.6123 | 0.0000 | |
| GSE53624 | CHSY1 | 22856 | 136537 | 0.7587 | 0.0000 | |
| GSE63941 | CHSY1 | 22856 | 203044_at | -0.9574 | 0.0896 | |
| GSE77861 | CHSY1 | 22856 | 203044_at | 0.7377 | 0.0212 | |
| GSE97050 | CHSY1 | 22856 | A_23_P37484 | 0.5129 | 0.1708 | |
| SRP007169 | CHSY1 | 22856 | RNAseq | 1.3705 | 0.0008 | |
| SRP008496 | CHSY1 | 22856 | RNAseq | 1.7497 | 0.0000 | |
| SRP064894 | CHSY1 | 22856 | RNAseq | 0.5256 | 0.0753 | |
| SRP133303 | CHSY1 | 22856 | RNAseq | 0.8518 | 0.0000 | |
| SRP159526 | CHSY1 | 22856 | RNAseq | 0.8084 | 0.0008 | |
| SRP193095 | CHSY1 | 22856 | RNAseq | 1.0511 | 0.0000 | |
| SRP219564 | CHSY1 | 22856 | RNAseq | 0.5767 | 0.0656 | |
| TCGA | CHSY1 | 22856 | RNAseq | 0.0281 | 0.6157 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by CHSY1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHSY1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHSY1 | 22856 | 6 | 2 | 22 | |
| GSE20123 | CHSY1 | 22856 | 6 | 2 | 22 | |
| GSE43470 | CHSY1 | 22856 | 6 | 5 | 32 | |
| GSE46452 | CHSY1 | 22856 | 3 | 7 | 49 | |
| GSE47630 | CHSY1 | 22856 | 9 | 10 | 21 | |
| GSE54993 | CHSY1 | 22856 | 4 | 7 | 59 | |
| GSE54994 | CHSY1 | 22856 | 8 | 7 | 38 | |
| GSE60625 | CHSY1 | 22856 | 4 | 0 | 7 | |
| GSE74703 | CHSY1 | 22856 | 5 | 4 | 27 | |
| GSE74704 | CHSY1 | 22856 | 3 | 3 | 14 | |
| TCGA | CHSY1 | 22856 | 19 | 11 | 66 |
Total number of gains: 73; Total number of losses: 58; Total Number of normals: 357.
Somatic mutations of CHSY1:
Generating mutation plots.
Highly correlated genes for CHSY1:
Showing top 20/1346 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHSY1 | CSGALNACT2 | 0.727052 | 11 | 0 | 11 |
| CHSY1 | FMNL2 | 0.726295 | 7 | 0 | 7 |
| CHSY1 | SLC39A14 | 0.7185 | 11 | 0 | 11 |
| CHSY1 | MICAL1 | 0.716642 | 3 | 0 | 3 |
| CHSY1 | FCGR3A | 0.716007 | 3 | 0 | 3 |
| CHSY1 | NNMT | 0.704905 | 4 | 0 | 3 |
| CHSY1 | LPCAT1 | 0.702489 | 11 | 0 | 11 |
| CHSY1 | ITGAV | 0.701851 | 11 | 0 | 11 |
| CHSY1 | LRRC8C | 0.70131 | 3 | 0 | 3 |
| CHSY1 | TMEM263 | 0.696127 | 6 | 0 | 6 |
| CHSY1 | COL5A2 | 0.691176 | 13 | 0 | 13 |
| CHSY1 | PMEPA1 | 0.690079 | 11 | 0 | 10 |
| CHSY1 | SPON2 | 0.688055 | 3 | 0 | 3 |
| CHSY1 | IRF9 | 0.687601 | 4 | 0 | 4 |
| CHSY1 | DPY19L1 | 0.687166 | 12 | 0 | 12 |
| CHSY1 | PDGFA | 0.686905 | 10 | 0 | 9 |
| CHSY1 | PPP1R18 | 0.685278 | 6 | 0 | 5 |
| CHSY1 | CBX3 | 0.683086 | 10 | 0 | 9 |
| CHSY1 | COL5A1 | 0.681055 | 13 | 0 | 13 |
| CHSY1 | PLAU | 0.679964 | 11 | 0 | 10 |
For details and further investigation, click here
