| Full name: large 60S subunit nuclear export GTPase 1 | Alias Symbol: FLJ11301 | ||
| Type: protein-coding gene | Cytoband: 3q29 | ||
| Entrez ID: 55341 | HGNC ID: HGNC:25652 | Ensembl Gene: ENSG00000041802 | OMIM ID: 610780 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LSG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LSG1 | 55341 | 221535_at | 0.7656 | 0.1276 | |
| GSE20347 | LSG1 | 55341 | 221535_at | 1.0103 | 0.0000 | |
| GSE23400 | LSG1 | 55341 | 221535_at | 0.6542 | 0.0000 | |
| GSE26886 | LSG1 | 55341 | 221536_s_at | 1.2172 | 0.0001 | |
| GSE29001 | LSG1 | 55341 | 221536_s_at | 1.3375 | 0.0000 | |
| GSE38129 | LSG1 | 55341 | 221535_at | 0.9944 | 0.0000 | |
| GSE45670 | LSG1 | 55341 | 221536_s_at | 1.1322 | 0.0000 | |
| GSE53622 | LSG1 | 55341 | 42706 | 0.7463 | 0.0000 | |
| GSE53624 | LSG1 | 55341 | 42706 | 1.0197 | 0.0000 | |
| GSE63941 | LSG1 | 55341 | 221536_s_at | 0.4544 | 0.2560 | |
| GSE77861 | LSG1 | 55341 | 221536_s_at | 0.9476 | 0.0011 | |
| GSE97050 | LSG1 | 55341 | A_23_P132417 | 0.0315 | 0.9640 | |
| SRP007169 | LSG1 | 55341 | RNAseq | 1.9971 | 0.0001 | |
| SRP008496 | LSG1 | 55341 | RNAseq | 2.3328 | 0.0000 | |
| SRP064894 | LSG1 | 55341 | RNAseq | 1.0401 | 0.0000 | |
| SRP133303 | LSG1 | 55341 | RNAseq | 1.1201 | 0.0000 | |
| SRP159526 | LSG1 | 55341 | RNAseq | 1.6026 | 0.0000 | |
| SRP193095 | LSG1 | 55341 | RNAseq | 0.8228 | 0.0000 | |
| SRP219564 | LSG1 | 55341 | RNAseq | 0.6648 | 0.0334 | |
| TCGA | LSG1 | 55341 | RNAseq | 0.3052 | 0.0000 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by LSG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LSG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LSG1 | 55341 | 22 | 0 | 8 | |
| GSE20123 | LSG1 | 55341 | 22 | 0 | 8 | |
| GSE43470 | LSG1 | 55341 | 24 | 0 | 19 | |
| GSE46452 | LSG1 | 55341 | 19 | 1 | 39 | |
| GSE47630 | LSG1 | 55341 | 27 | 2 | 11 | |
| GSE54993 | LSG1 | 55341 | 1 | 22 | 47 | |
| GSE54994 | LSG1 | 55341 | 41 | 0 | 12 | |
| GSE60625 | LSG1 | 55341 | 0 | 6 | 5 | |
| GSE74703 | LSG1 | 55341 | 20 | 0 | 16 | |
| GSE74704 | LSG1 | 55341 | 14 | 0 | 6 | |
| TCGA | LSG1 | 55341 | 77 | 0 | 19 |
Total number of gains: 267; Total number of losses: 31; Total Number of normals: 190.
Somatic mutations of LSG1:
Generating mutation plots.
Highly correlated genes for LSG1:
Showing top 20/2070 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LSG1 | PPP1R37 | 0.817597 | 3 | 0 | 3 |
| LSG1 | RBM26 | 0.811056 | 3 | 0 | 3 |
| LSG1 | KLHL5 | 0.801781 | 3 | 0 | 3 |
| LSG1 | CCDC15 | 0.782221 | 3 | 0 | 3 |
| LSG1 | MCM3AP | 0.779042 | 3 | 0 | 3 |
| LSG1 | EIF3C | 0.76973 | 3 | 0 | 3 |
| LSG1 | UCK2 | 0.76812 | 3 | 0 | 3 |
| LSG1 | SLC25A29 | 0.764609 | 3 | 0 | 3 |
| LSG1 | FNBP1L | 0.764034 | 3 | 0 | 3 |
| LSG1 | ZNF628 | 0.759968 | 3 | 0 | 3 |
| LSG1 | LRRC58 | 0.759696 | 5 | 0 | 5 |
| LSG1 | DYRK2 | 0.756873 | 3 | 0 | 3 |
| LSG1 | POLR2H | 0.756826 | 12 | 0 | 12 |
| LSG1 | ALKBH6 | 0.748156 | 5 | 0 | 5 |
| LSG1 | ATR | 0.746824 | 11 | 0 | 11 |
| LSG1 | ACTL6A | 0.742568 | 13 | 0 | 12 |
| LSG1 | FAM89A | 0.741589 | 3 | 0 | 3 |
| LSG1 | MORC2 | 0.741445 | 11 | 0 | 11 |
| LSG1 | LMLN | 0.740799 | 5 | 0 | 5 |
| LSG1 | SPNS1 | 0.740077 | 3 | 0 | 3 |
For details and further investigation, click here
