PIK3R1

 

Full name: phosphoinositide-3-kinase regulatory subunit 1 Alias Symbol: GRB1|p85-ALPHA|p85
Type: protein-coding gene Cytoband: 5q13.1
Entrez ID: 5295 HGNC ID: HGNC:8979 Ensembl Gene: ENSG00000145675 OMIM ID: 171833
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 7/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

PIK3R1 involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04210Apoptosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04611Platelet activation
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04668TNF signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04930Type II diabetes mellitus
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04960Aldosterone-regulated sodium reabsorption
hsa04973Carbohydrate digestion and absorption
hsa05100Bacterial invasion of epithelial cells
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of PIK3R1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PIK3R1 5295 212240_s_at -0.7235 0.5231
GSE20347 PIK3R1 5295 212240_s_at -0.2781 0.3810
GSE23400 PIK3R1 5295 212240_s_at -0.1451 0.3647
GSE26886 PIK3R1 5295 212239_at -1.0657 0.0068
GSE29001 PIK3R1 5295 212239_at -0.8034 0.0679
GSE38129 PIK3R1 5295 212240_s_at -0.7167 0.0031
GSE45670 PIK3R1 5295 212239_at -1.3795 0.0000
GSE53622 PIK3R1 5295 91106 -1.0957 0.0000
GSE53624 PIK3R1 5295 91106 -0.9023 0.0000
GSE63941 PIK3R1 5295 212240_s_at -0.5137 0.4819
GSE77861 PIK3R1 5295 212239_at -0.8488 0.0076
GSE97050 PIK3R1 5295 A_24_P29401 -1.1307 0.0903
SRP007169 PIK3R1 5295 RNAseq 0.3811 0.2916
SRP008496 PIK3R1 5295 RNAseq 0.6921 0.0008
SRP064894 PIK3R1 5295 RNAseq -0.4985 0.1102
SRP133303 PIK3R1 5295 RNAseq -0.7032 0.0061
SRP159526 PIK3R1 5295 RNAseq -0.1111 0.8623
SRP193095 PIK3R1 5295 RNAseq -0.3633 0.0267
SRP219564 PIK3R1 5295 RNAseq -0.5756 0.3437
TCGA PIK3R1 5295 RNAseq -0.3240 0.0000

Upregulated datasets: 0; Downregulated datasets: 3.  

 

Survival by PIK3R1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PIK3R1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PIK3R1 5295 1 13 16
GSE20123 PIK3R1 5295 1 13 16
GSE43470 PIK3R1 5295 1 12 30
GSE46452 PIK3R1 5295 0 28 31
GSE47630 PIK3R1 5295 2 17 21
GSE54993 PIK3R1 5295 8 1 61
GSE54994 PIK3R1 5295 1 19 33
GSE60625 PIK3R1 5295 0 0 11
GSE74703 PIK3R1 5295 1 9 26
GSE74704 PIK3R1 5295 1 6 13
TCGA PIK3R1 5295 4 50 42

Total number of gains: 20; Total number of losses: 168; Total Number of normals: 300.  

 

Somatic mutations of PIK3R1:

 

Generating mutation plots.

 

Highly correlated genes for PIK3R1:

 

Showing top 20/1237 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PIK3R1TNFSF120.801833303
PIK3R1PDS5B0.796522303
PIK3R1CD590.780341303
PIK3R1RAB9B0.778066505
PIK3R1LRRN4CL0.771658505
PIK3R1TCEAL60.770057303
PIK3R1C1QTNF70.769675505
PIK3R1GPRASP20.766896303
PIK3R1IMPA10.761561303
PIK3R1NR2F10.756155303
PIK3R1FRMD30.755949505
PIK3R1FOXO30.753927303
PIK3R1ZNF585A0.75145303
PIK3R1KDM5D0.749476303
PIK3R1CLEC3B0.745591303
PIK3R1NCKAP10.744177303
PIK3R1CYP2U10.743854504
PIK3R1POLK0.743487404
PIK3R1TCEAL50.743082303
PIK3R1KLHL230.742601303

For details and further investigation, click here