| Full name: CD59 molecule (CD59 blood group) | Alias Symbol: 16.3A5|EJ16|EJ30|EL32|G344|p18-20 | ||
| Type: protein-coding gene | Cytoband: 11p13 | ||
| Entrez ID: 966 | HGNC ID: HGNC:1689 | Ensembl Gene: ENSG00000085063 | OMIM ID: 107271 |
| Drug and gene relationship at DGIdb | |||
Expression of CD59:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD59 | 966 | 200985_s_at | -0.6477 | 0.1865 | |
| GSE20347 | CD59 | 966 | 200983_x_at | -1.5724 | 0.0000 | |
| GSE23400 | CD59 | 966 | 200983_x_at | -0.8712 | 0.0000 | |
| GSE26886 | CD59 | 966 | 200985_s_at | -1.1213 | 0.0000 | |
| GSE29001 | CD59 | 966 | 212463_at | -1.0788 | 0.0177 | |
| GSE38129 | CD59 | 966 | 200985_s_at | -0.9022 | 0.0000 | |
| GSE45670 | CD59 | 966 | 200983_x_at | -0.2737 | 0.2660 | |
| GSE63941 | CD59 | 966 | 200983_x_at | -1.0225 | 0.1158 | |
| GSE77861 | CD59 | 966 | 200983_x_at | -1.0934 | 0.0048 | |
| GSE97050 | CD59 | 966 | A_24_P784765 | -0.5165 | 0.1372 | |
| SRP007169 | CD59 | 966 | RNAseq | -2.3077 | 0.0000 | |
| SRP008496 | CD59 | 966 | RNAseq | -1.9449 | 0.0000 | |
| SRP064894 | CD59 | 966 | RNAseq | -0.9550 | 0.0000 | |
| SRP133303 | CD59 | 966 | RNAseq | -0.2212 | 0.4196 | |
| SRP159526 | CD59 | 966 | RNAseq | -1.0755 | 0.0028 | |
| SRP193095 | CD59 | 966 | RNAseq | -0.9064 | 0.0000 | |
| SRP219564 | CD59 | 966 | RNAseq | -0.8855 | 0.0015 | |
| TCGA | CD59 | 966 | RNAseq | -0.1858 | 0.0005 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by CD59 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CD59:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD59 | 966 | 1 | 6 | 23 | |
| GSE20123 | CD59 | 966 | 1 | 5 | 24 | |
| GSE43470 | CD59 | 966 | 2 | 4 | 37 | |
| GSE46452 | CD59 | 966 | 8 | 5 | 46 | |
| GSE47630 | CD59 | 966 | 3 | 10 | 27 | |
| GSE54993 | CD59 | 966 | 3 | 1 | 66 | |
| GSE54994 | CD59 | 966 | 4 | 9 | 40 | |
| GSE60625 | CD59 | 966 | 0 | 0 | 11 | |
| GSE74703 | CD59 | 966 | 2 | 2 | 32 | |
| GSE74704 | CD59 | 966 | 0 | 3 | 17 | |
| TCGA | CD59 | 966 | 14 | 24 | 58 |
Total number of gains: 38; Total number of losses: 69; Total Number of normals: 381.
Somatic mutations of CD59:
Generating mutation plots.
Highly correlated genes for CD59:
Showing top 20/1234 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD59 | RAB18 | 0.840827 | 3 | 0 | 3 |
| CD59 | EVC2 | 0.81704 | 3 | 0 | 3 |
| CD59 | PCBD2 | 0.796926 | 3 | 0 | 3 |
| CD59 | PIK3R1 | 0.780341 | 3 | 0 | 3 |
| CD59 | FAM162B | 0.774563 | 3 | 0 | 3 |
| CD59 | KDM5D | 0.774293 | 3 | 0 | 3 |
| CD59 | AK3 | 0.761541 | 4 | 0 | 4 |
| CD59 | CNN3 | 0.756968 | 7 | 0 | 7 |
| CD59 | ARPC1A | 0.752611 | 3 | 0 | 3 |
| CD59 | KIAA2026 | 0.751307 | 3 | 0 | 3 |
| CD59 | FBXO10 | 0.750363 | 3 | 0 | 3 |
| CD59 | TAB3 | 0.749045 | 4 | 0 | 4 |
| CD59 | GSKIP | 0.745269 | 3 | 0 | 3 |
| CD59 | SLC44A3 | 0.743272 | 4 | 0 | 4 |
| CD59 | C5orf24 | 0.739535 | 3 | 0 | 3 |
| CD59 | C15orf48 | 0.738556 | 3 | 0 | 3 |
| CD59 | MBNL3 | 0.73832 | 4 | 0 | 4 |
| CD59 | RPS27L | 0.736821 | 3 | 0 | 3 |
| CD59 | JDP2 | 0.735343 | 3 | 0 | 3 |
| CD59 | CGGBP1 | 0.735017 | 5 | 0 | 4 |
For details and further investigation, click here
