| Full name: inositol monophosphatase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q21.13 | ||
| Entrez ID: 3612 | HGNC ID: HGNC:6050 | Ensembl Gene: ENSG00000133731 | OMIM ID: 602064 |
| Drug and gene relationship at DGIdb | |||
Expression of IMPA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IMPA1 | 3612 | 203011_at | -0.3875 | 0.3178 | |
| GSE20347 | IMPA1 | 3612 | 203011_at | -0.2880 | 0.2065 | |
| GSE23400 | IMPA1 | 3612 | 203011_at | -0.1308 | 0.1206 | |
| GSE26886 | IMPA1 | 3612 | 203011_at | -1.1786 | 0.0001 | |
| GSE29001 | IMPA1 | 3612 | 203011_at | -0.3244 | 0.1677 | |
| GSE38129 | IMPA1 | 3612 | 203011_at | -0.1378 | 0.4113 | |
| GSE45670 | IMPA1 | 3612 | 203011_at | -0.1747 | 0.1556 | |
| GSE53622 | IMPA1 | 3612 | 10805 | -0.4909 | 0.0000 | |
| GSE53624 | IMPA1 | 3612 | 10805 | -0.4447 | 0.0000 | |
| GSE63941 | IMPA1 | 3612 | 203011_at | 0.0176 | 0.9775 | |
| GSE77861 | IMPA1 | 3612 | 203011_at | -0.4846 | 0.2788 | |
| GSE97050 | IMPA1 | 3612 | A_24_P183864 | -0.0086 | 0.9738 | |
| SRP007169 | IMPA1 | 3612 | RNAseq | -1.1553 | 0.0014 | |
| SRP008496 | IMPA1 | 3612 | RNAseq | -0.7235 | 0.0058 | |
| SRP064894 | IMPA1 | 3612 | RNAseq | -0.0430 | 0.8721 | |
| SRP133303 | IMPA1 | 3612 | RNAseq | -0.0129 | 0.9338 | |
| SRP159526 | IMPA1 | 3612 | RNAseq | -0.8168 | 0.0064 | |
| SRP193095 | IMPA1 | 3612 | RNAseq | -0.5272 | 0.0000 | |
| SRP219564 | IMPA1 | 3612 | RNAseq | -0.6862 | 0.0070 | |
| TCGA | IMPA1 | 3612 | RNAseq | -0.0617 | 0.2733 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by IMPA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IMPA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IMPA1 | 3612 | 16 | 1 | 13 | |
| GSE20123 | IMPA1 | 3612 | 18 | 1 | 11 | |
| GSE43470 | IMPA1 | 3612 | 18 | 1 | 24 | |
| GSE46452 | IMPA1 | 3612 | 21 | 0 | 38 | |
| GSE47630 | IMPA1 | 3612 | 23 | 0 | 17 | |
| GSE54993 | IMPA1 | 3612 | 0 | 19 | 51 | |
| GSE54994 | IMPA1 | 3612 | 30 | 0 | 23 | |
| GSE60625 | IMPA1 | 3612 | 0 | 4 | 7 | |
| GSE74703 | IMPA1 | 3612 | 15 | 1 | 20 | |
| GSE74704 | IMPA1 | 3612 | 12 | 0 | 8 | |
| TCGA | IMPA1 | 3612 | 51 | 2 | 43 |
Total number of gains: 204; Total number of losses: 29; Total Number of normals: 255.
Somatic mutations of IMPA1:
Generating mutation plots.
Highly correlated genes for IMPA1:
Showing top 20/713 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IMPA1 | GGA3 | 0.807446 | 3 | 0 | 3 |
| IMPA1 | GPCPD1 | 0.787657 | 3 | 0 | 3 |
| IMPA1 | COG6 | 0.770426 | 3 | 0 | 3 |
| IMPA1 | PIK3R1 | 0.761561 | 3 | 0 | 3 |
| IMPA1 | C5orf51 | 0.753234 | 3 | 0 | 3 |
| IMPA1 | POLI | 0.750017 | 3 | 0 | 3 |
| IMPA1 | TRAPPC2 | 0.73863 | 3 | 0 | 3 |
| IMPA1 | NKTR | 0.737758 | 3 | 0 | 3 |
| IMPA1 | AP3M1 | 0.734429 | 3 | 0 | 3 |
| IMPA1 | CCNYL1 | 0.730136 | 3 | 0 | 3 |
| IMPA1 | PNRC2 | 0.729025 | 3 | 0 | 3 |
| IMPA1 | ACVR2A | 0.725287 | 3 | 0 | 3 |
| IMPA1 | RBM20 | 0.721245 | 5 | 0 | 5 |
| IMPA1 | GALNT11 | 0.718046 | 3 | 0 | 3 |
| IMPA1 | ZRANB2 | 0.712771 | 4 | 0 | 3 |
| IMPA1 | ABHD14B | 0.706367 | 3 | 0 | 3 |
| IMPA1 | TMEM220 | 0.698433 | 4 | 0 | 4 |
| IMPA1 | USP9Y | 0.697979 | 3 | 0 | 3 |
| IMPA1 | DCUN1D4 | 0.688559 | 5 | 0 | 4 |
| IMPA1 | HDHD2 | 0.683165 | 4 | 0 | 3 |
For details and further investigation, click here
